A5002589449- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Circular RNAs in diseases
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- Metabolomics and Mass Spectrometry Studies
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Colorectal Cancer Screening and Detection
- Hepatitis Viruses Studies and Epidemiology
- Congenital Anomalies and Fetal Surgery
- Cancer Genomics and Diagnostics
- Tryptophan and brain disorders
- Parathyroid Disorders and Treatments
- COVID-19 and healthcare impacts
- Thyroid Disorders and Treatments
- Inflammatory mediators and NSAID effects
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- Pharmacogenetics and Drug Metabolism
Tehran University of Medical Sciences
2016-2025
Shariati Hospital
2010-2025
University of North Carolina at Chapel Hill
2018-2021
University of Tehran
2010-2021
Islamic Azad University Boroujerd Branch
2019-2020
David H. Murdock Research Institute
2019
Golestan University of Medical Sciences
2015
Golestan University
2015
Tarbiat Modares University
2010-2014
Lorestan University
2014
Abstract Background Pancreatic cancer (PC) presents a significant challenge in oncology because of its late-stage diagnosis and limited treatment options. The inadequacy current screening methods has prompted investigations into stool-based assays microbial classifiers as potential early detection markers. gut microbiota composition PC patients may be influenced by population differences, thereby impacting the accuracy disease prediction. However, comprehensive profiling analysis these...
Most cancer studies focus on exploring non-invasive biomarkers for detection. In the present study, we sought to investigate expression level of microRNA-21 (miR-21), as a potential diagnostic marker, in serum and stool samples from 40 patients with colorectal (CRC) healthy controls.Quantitative real-time RT-PCR was applied determine relative miR-21 stool. At same time, sensitivity specificity this marker evaluated by receiver operating characteristic (ROC) curve analysis.miR-21 levels were...
Colorectal cancer is one of the most commonly diagnosed cancers and cancer- related death worldwide. Identification new specific biomarkers could be helpful to detection this malignancy. Altered plasma microRNA expression has been identified in many cancers, including colorectal cancer.The main objective study was identify circulating microRNAs with changes patients compared neoplasm free healthy individuals.MicroRNA profiling performed on samples 37 8 normal subjects using microarray....
Colorectal cancer (CRC) is the third most common malignancy and second cause of death worldwide. Early detection CRC can improve patient survival rates; thus, identification noninvasive diagnostic markers urgently needed. MicroRNAs (miRNAs) have extensive potential to diagnose several diseases, including cancer. In this study, we compared expression pattern miRNAs from plasma stool samples patients with early stages (I, II) that healthy subjects. We performed miRNA profiling using...
COVID-19 caused by SARS-CoV-2, is an international concern. This infection requires urgent efforts to develop new antiviral compounds. To date, no specific drug in controlling this disease has been identified. Developing the treatment usually time consuming, therefore using repurposing broad-spectrum drugs could be effective strategy respond immediately. In review, a number of antivirals with potential efficacy inhibit virus replication via targeting spike protein (S protein), RNA-dependent...
Abstract Background COVID-19 has caused great concern for patients with underlying medical conditions. We aimed to determine the prognosis of current or previous cancer either a PCR-confirmed infection probable diagnosis according chest CT scan. Methods conducted case control study in referral hospital on confirmed adult and without history from February 25th April 21st , 2020. Patients were matched age, gender, diseases including ischemic heart disease (IHD), diabetes mellitus (DM),...
Introduction: Burnout is a psychological syndrome that develops due to chronic stressors in person's professional life, resulting emotional exhaustion and detachment. The objective of this study was determine the prevalence burnout among medical residents, considering socio-demographic variables job characteristics, predict group. Medical residents often face specific pressures such as long working hours, sleep deprivation, high patient loads, demands from care, which contribute their...
Background: Colorectal cancer (CRC) is a major cause of cancer-related deaths world-wide. Detection molecular markers in stool samples promising strategy for CRC screening. MicroRNAs (miRNAs) are short, non-coding RNA molecules that commo
Fecal samples are currently the most commonly studied proxy for gut microbiota. The gold standard of sample handling and storage microbiota analysis is maintaining cold chain during transfer immediate at - 80 °C. Gut studies in large-scale, population-based cohorts require a feasible collection protocol. We compared effect three different methods mock shipment: freezing °C, 95% ethanol stored room temperature (RT) 48 h, on blood card RT measured composition fecal eight healthy, female...
Objective: Over 50 million people worldwide are estimated to use opioids, of which ~30 opiates (opium and its derivatives). Use has been associated with a variety adverse complications such as neurological behavioral outcomes, addiction, cancers, diabetes, cardiovascular disease. While it is well known that exert their neurobiological effects through binding mu, kappa, delta receptors analgesic sedative effects, mechanistic links other health not understood. Our study focuses on the...
Abstract Opioid use disorder (OUD) is diagnosed using the qualitative criteria defined by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). biomarkers for OUD do not currently exist. Our study focused on developing objective biological markers to differentiate chronic opiate users with from without OUD. Using biospecimens Golestan Cohort Study, we compared metabolomics profiles high opium who were as positive negative. High was maximum weekly usage greater than or...
Abstract BACKGROUND The natural history of hepatitis B virus (HBV) is complex and influenced by the level viral replication host factors. hepatoprotective role high density lipoproteins (HDL) adiponectin as factors on HBV persistence less well understood. METHODS To investigate correlation between DNA with clinical parameters in patients chronic B, 92 male subjects infection without any risk for diabetes were enrolled this study. Age BMI study population matched DNA, ALT, tumor necrosis...
Chronic Hepatitis B (CHB) is accompanied by inflammation of liver because infection with Virus (HBV). Previous studies revealed an inverse association between vitamin D and HBV DNA levels.The current study aimed to investigate the levels 25 (OH) D3 (the steady form D), miR-378 in patients CHB.One hundred seventy three HBeAg negative CHB were recruited for study. Plasma HBVDNA quantified. The expression level plasma was measured a relative quantitative Real Time Polymerase Chain Reaction...
Abnormal activation of Toll-like receptor (TLRs) signaling can result in colon cancer development. The aim this study was to investigate the expression important TLRs different histological types colorectal polyps and evaluate their relationship with intestinal microbiota. levels TLR2, 3, 4, 5 were analyzed biopsy specimens 21 hyperplastic polyp (HP), 16 sessile serrated adenoma (SSA), 29 tubular (TA), villous/tubulovillous (VP/TVP) cases, 31 normal controls. In addition, selected gut...
Exhaled breath condensate (EBC) is used to investigate the efficacy of EBC detect genetic mutations in patients with lung cancer. Samples 5 and healthy volunteers were collected. DNA was extracted for amplification hotspot regions TP53 KRAS genes by using PCR. We performed mutation analysis direct sequencing all subjects. Detected samples compared those corresponding tumor tissues there complete agreement within detected tumorous tissue. can be as an efficient noninvasive source assessment gene
Non-communicable diseases (NCDs) are the leading cause of death worldwide, with a disproportionally rising burden among low- and middle-income populations. While preventable risk factors highly contribute to this burden, population-based studies assessing these health status populations, scarce.The Khuzestan Comprehensive Health Study (KCHS)-a cross sectional study-was conducted between 2016-2019, including 30,506 Iranians aged 20 65 years, from 27 counties province, southwest Iran. KCHS...