A5048196999- 3D Printing in Biomedical Research
- Sexual function and dysfunction studies
- Tissue Engineering and Regenerative Medicine
- Salivary Gland Disorders and Functions
- Urological Disorders and Treatments
- Risk and Safety Analysis
- Sexual Differentiation and Disorders
- Cancer Cells and Metastasis
- Proteoglycans and glycosaminoglycans research
- Genital Health and Disease
- Hedgehog Signaling Pathway Studies
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Occupational Health and Safety Research
- Supramolecular Self-Assembly in Materials
- Transportation Safety and Impact Analysis
- Electrospun Nanofibers in Biomedical Applications
- Safety and Risk Management
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Structural Response to Dynamic Loads
- Cellular Mechanics and Interactions
- Cancer Research and Treatments
- Bone health and treatments
- Mining Techniques and Economics
The University of Texas Health Science Center at Houston
2017-2024
Rice University
2014-2023
Louisiana State University Health Sciences Center New Orleans
2017-2022
The University of Texas MD Anderson Cancer Center
2021
eHealth Initiative
2019
University of Houston
2018
University of Illinois Chicago
2011-2017
University of Southern Queensland
2013
Northwestern University
2002-2011
Lurie Children's Hospital
2005-2011
Neural progenitor cells were encapsulated in vitro within a three-dimensional network of nanofibers formed by self-assembly peptide amphiphile molecules. The is triggered mixing cell suspensions media with dilute aqueous solutions the molecules, and survive growth around them. These designed to present neurite-promoting laminin epitope IKVAV at nearly van der Waals density. Relative or soluble peptide, artificial nanofiber scaffold induced very rapid differentiation into neurons, while...
Hyaluronic acid (HA) is one of nature's most versatile and fascinating macromolecules. Being an essential component the natural extracellular matrix (ECM), HA plays important role in a variety biological processes. Inherently biocompatible, biodegradable non-immunogenic, attractive starting material for construction hydrogels with desired morphology, stiffness bioactivity. While interconnected network extends to macroscopic level bulk gels, hydrogel particles (HGPs, microgels or nanogels)...
Human cardiac progenitor cells (hCPCs) may promote myocardial regeneration in adult ischemic myocardium. The regenerative capacity of hCPCs young patients with nonischemic congenital heart defects for potential use defect repair warrants exploration.Human right atrial specimens were obtained during routine surgery across 3 groups: neonates (age, <30 days), infants 1 month to 2 years), and children >2 ≤13 years). C-kit(+) 3-fold higher than years age. hCPC proliferation was greatest the...
Branched peptide amphiphile (PA) molecules bearing biological epitopes were designed and synthesized using orthogonal protecting group chemistry on amine groups at lysine residues. These self-assemble into high-aspect-ratio cylindrical nanofibers, their branched architecture enhances accessibility of for protein binding also allows the presentation more than one epitope in a single molecule. The RGDS cell adhesion was used as model bioactive signal PA potential biomedical applications....
Abstract An important challenge in regenerative medicine is the design of suitable bioactive scaffold materials that can act as artificial extracellular matrices. We reported previously on a family peptide‐amphiphile (PA) molecules self‐assemble into high‐aspect ratio nanofibers under physiological conditions, and display peptide epitopes along each nanofiber's periphery. One type PA displays its epitope at branched site using lysine dendron, molecular feature improves availability nanofiber...
We report here on the synthesis and characterization of a series self-assembling biomaterials with molecular features designed to interact cells scaffolds for tissue regeneration. The molecules these materials contain cholesteryl moieties, which have universal affinity cell membranes, short chains lactic acid, common component biodegradable engineering matrices. were synthesized in good yields low polydispersities range 1.05-1.15, their was carried out by small-angle x-ray diffraction,...
The lack of effective therapies for bone metastatic prostate cancer (PCa) underscores the need accurate models disease to enable discovery new therapeutic targets and test drug sensitivities individual tumors. To this end, patient-derived xenograft (PDX) PCa model using immunocompromised mice was established with greater fidelity than is possible currently employed cell lines grown on tissue culture plastic. However, poorly adherent PDX tumor cells exhibit low viability in standard culture,...
Radiation treatment in patients with head and neck tumors commonly results hyposalivation xerostomia due to the loss of fluid-secreting salivary acinar cells. Patients develop susceptibility oral infections, dental caries, impaired speech swallowing, reducing quality life. Clinical management is largely unsatisfactory. The development a tissue-engineered, implantable gland will greatly benefit suffering from xerostomia. This report compares ability 2.5-dimensional (2.5D) three-dimensional...
Abstract Radiotherapy for head and neck cancer often has undesirable effects on salivary glands that lead to xerostomia or severe dry mouth, which can increase oral infections. Our goal is engineer functional, three-dimensional (3D) gland neotissue autologous implantation provide permanent relief. An immediate need exists obtain adult progenitor cells as the use of embryonic induced pluripotent stem potentially pose serious risks such teratogenicity immunogenic rejection. Here, we report an...
This review discusses synthetic matrices specifically designed to harvest the regenerative potential of stem/progenitor cells for restoration salivary gland function.
Validation of a high-throughput compatible 3D hyaluronic acid hydrogel coculture cancer cells with stromal cells. The multilayered hydrogels improve drug screening predictability as evaluated panel clinically relevant chemotherapeutics in both prostate and endometrial cell lines compared to 2D culture. As service our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but not...
Current treatments for chronic xerostomia, or "dry mouth", do not offer long-term therapeutic benefits head and neck cancer survivors previously treated with curative radiation. Towards the goal of creating tissue-engineered constructs restoration salivary gland functions, we developed new hyaluronic acid (HA)-based hydrogels using thiolated HA (HA-SH) acrylated (HA-AES) a significant molecular weight mismatch. Four hydrogel formulations varying concentration, (1-2.4 wt%) thiol/acrylate...
To create a novel model for development of tissue-engineered salivary gland from human cells that retains progenitor cell markers useful treatment radiation-induced xerostomia.A three-dimensional (3D) hyaluronic acid (HA)-based hydrogel scaffold was used to encapsulate primary and obtain organized acini-like spheroids. Hydrogels were implanted into rat models, viability receptor expression evaluated.A parotid surgical resection xenografting developed. Salivary loaded in HA hydrogels formed...
Several recent reports have documented the neuroinvasiveness of human herpesvirus-6 (HHV-6) in infants with primary HHV-6 infections, children and adults AIDS, recipients bone marrow transplants, immunologically intact children. CNS infections can be subacute are frequently associated diffuse or multifocal demyelination. We analyzed tissues a young woman who died demyelinative disease, which was clinically histopathologically diagnosed as acute multiple sclerosis, for active infection by...