A5103175112- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Family and Disability Support Research
- Attention Deficit Hyperactivity Disorder
- Neuroendocrine regulation and behavior
- Child Nutrition and Feeding Issues
- Child and Adolescent Psychosocial and Emotional Development
- Face Recognition and Perception
- Congenital heart defects research
- Infant Health and Development
- Genomic variations and chromosomal abnormalities
- Behavioral and Psychological Studies
- Child Development and Digital Technology
- Neurofibromatosis and Schwannoma Cases
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Children's Physical and Motor Development
- Language Development and Disorders
- Heart Rate Variability and Autonomic Control
- Obsessive-Compulsive Spectrum Disorders
- Attachment and Relationship Dynamics
- Evolutionary Psychology and Human Behavior
- EEG and Brain-Computer Interfaces
- Williams Syndrome Research
- Advanced Neuroimaging Techniques and Applications
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2003-2025
VIB-KU Leuven Center for Microbiology
2024
University of Antwerp
2023
Ghent University
2023
Leuven Security Excellence Consortium
2020
UCLouvain
2019
Maastricht University Medical Centre
2005-2017
Maastricht University
1994-2014
New York University
2013
The development of language, social interaction and communicative skills is remarkably different in the child with autism spectrum disorder (ASD). Atypical brain connectivity has frequently been reported this patient population. However, neural correlates underlying their disrupted language functioning are still poorly understood. Using resting state fMRI, we investigated functional properties network a group ASD patients clear comorbid impairment (ASD-LI; N = 19) compared them to related 23...
Neurodevelopmental disconnections have been assumed to cause behavioral alterations in autism spectrum disorders (ASDs). Here, we combined measurements of intrinsic functional connectivity (iFC) from resting-state magnetic resonance imaging (fMRI) with task-based fMRI explore whether altered activity and/or iFC the right posterior superior temporal sulcus (pSTS) mediates deficits emotion recognition ASD. Fifteen adults ASD and 15 matched-controls underwent fMRI, during which participants...
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic condition. While considerable work has focused on cognitive functioning, several research groups also observed difficulties in social functioning as a prominent feature of NF1. These problems and the possible link between NF1 Autism Spectrum Disorder (ASD) have become increasingly important recent literature. The aim current study was to assess ASD characteristics hospital-based pediatric population (n = 82) using standardized...
Intranasal administration of the "prosocial" neuropeptide oxytocin is increasingly explored as a potential treatment for targeting core characteristics autism spectrum disorder (ASD). However, long-term follow-up studies, evaluating possibility long-lasting retention effects, are currently lacking.
Abstract Background Intranasal administration of oxytocin is increasingly explored as a new approach to facilitate social development and reduce disability associated with diagnosis autism spectrum disorder (ASD). The efficacy multiple-dose in children ASD is, however, not well established. Methods A double-blind, randomized, placebo-controlled trial parallel design the effects 4-week intranasal (12 IU, twice daily) on parent-rated responsiveness (Social Responsiveness Scale: SRS-2)...
Abstract Clinical efficacy of intranasal administration oxytocin is increasingly explored in autism spectrum disorder, but to date, the biological effects chronic regimes on endogenous oxytocinergic function are largely unknown. Here exploratory assessments from a completed randomized, placebo-controlled trial showed that children with (n = 79, 16 females) receiving for four weeks (12 IU, twice daily) displayed significantly higher salivary levels 24 hours after last nasal spray...
Autism is a neurodevelopmental disorder characterized by impaired social reciprocity, communication and stereotypical behaviors. Despite strong evidence for genetic basis, few susceptibility genes have been identified. Here, we describe the positional cloning of SCAMP5, CLIC4 PPCDC as candidate autism, starting from person with idiopathic, sporadic autism carrying de novo chromosomal translocation. One these genes, SCAMP5 silenced on derivative chromosome, encodes brain-enriched protein...
Verbal fluency was operationalized as the number of words produced in a restricted category (i.e., semantic [SCF] and beginning with given letter [ILF]) 60 seconds. Word production first 15 seconds either type task defined measure automatic information processing, whereas word remaining 45 (in 15-second periods) taken controlled processing. Data revealed that over healthy children aged 8.4–9.7 years (n = 91) significantly more less incorrect responses on SCF than ILF task. Although function...
Discussion of an overlap between specific language impairment (SLI) and autism spectrum disorder (ASD) is on going. The most intriguing both phenotypes the similarity in observed deficits described SLI a subgroup ASD with co-occurring linguistic impairment, ASD-LI. Examining whether similar neuroanatomical substrate underlies this phenotypical overlap, we studied white matter microstructural properties superior longitudinal fascicle (SLF) 19 ASD-LI adolescents (mean age 13.8 ± 1.6 years) 21...
Abstract Dyslexia is the most common childhood learning disorder and it a significantly heritable trait. At least nine chromosomal loci have been linked to dyslexia, additional susceptibility on other chromosomes suggested. Within two of these loci, DYX1C1 (15q21) ROBO1 (3p12) recently proposed as dyslexia candidate genes through molecular analysis translocation breakpoints in dyslexic individuals carrying balanced translocations. Moreover, genetic association studies indicated cluster five...
Over a half of all proteins are glycosylated, and their proper glycosylation is essential for normal function. Unfortunately, because structural complexity nonlinear branched glycans the absence genetic template synthesis, knowledge about lagging significantly behind or DNA. Using recently developed quantitative high throughput glycan analysis method we quantified components plasma N-glycome in 99 children with attention-deficit hyperactivity disorder (ADHD), 81 child 5 adults autism...
Individuals with autism spectrum disorder (ASD) are characterized by impairments in social communication and interaction. Although difficulties at processing signals from the face ASD have been observed emphasized for many years, there is a lot of inconsistency across both behavioral neural studies. We recorded scalp electroencephalography (EEG) 23 8-to-12 year old boys matched typically developing using fast periodic visual stimulation (FPVS) paradigm, providing objective (i.e.,...
The aim of this study was to provide a broad picture Executive Functioning (EF) in NF1 children, while taking into account their lower average IQ and increased Autism Spectrum Disorder (ASD) symptoms. This done by administering an extended battery tasks questionnaires, designed reduce task impurity, that measures five EF domains (inhibition, cognitive flexibility, working memory, generativity planning) laboratory setting daily life. Data are presented for 42 age‐ gender‐matched NF1, 52...