A5091864652- Phytochemicals and Antioxidant Activities
- Fatty Acid Research and Health
- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Free Radicals and Antioxidants
- Heavy Metals in Plants
- Trace Elements in Health
- Folate and B Vitamins Research
- Phytochemistry and Biological Activities
- Chemical synthesis and alkaloids
- Iron Metabolism and Disorders
- Eicosanoids and Hypertension Pharmacology
- Saffron Plant Research Studies
- Coenzyme Q10 studies and effects
- Natural product bioactivities and synthesis
- Natural Products and Biological Research
- Synthesis and biological activity
- Diet, Metabolism, and Disease
- Potato Plant Research
- Ginkgo biloba and Cashew Applications
- Biochemical effects in animals
- Cholinesterase and Neurodegenerative Diseases
Chiang Mai University
2009-2022
Ethanolic extracts of 30 Thai medicinal plants, traditionally used as alternative treatments in diabetes, were evaluated for antioxidative activity by the 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) method. They vitro oxidative stress thiobarbituric acid-reactive substance (TBARS) assay pooled plasma diabetic patients compared to without treatment (control). The also assayed protein glycation. results showed that five plants had strong antioxidant activity:...
Previous studies presented evidence that plants contain antioxidants have free radical-scavenging properties. Overproduction of radicals leads to oxidative stress, a factor associated with variety diseases, such as diabetes. Cytochrome P450 2E1 enzymes (CYP2E1) are involved in drug metabolism the liver and DNA-reaction generating intra-mitochondrial ROS, which micro- macro-vascular pathology Plant-based chemicals can affect CYP2E1 related defense mechanisms, possibly leading protection...
We investigated the effects of antioxidant activity fermentation product (FP) five Thai indigenous products on oxidative stress in Wistar rats with streptozotocin (STZ)‐induced diabetes type II. The were fed placebo and FP (2 6 mL/kg body weight/day) for weeks. Rutin, pyrogallol gallic acid main compounds found FP. Plasma glucose levels diabetic receiving higher dose increased less when compared to control group as well lower (13.1%, 29%, 21.1%), respectively. A significant dose‐dependent...
Abstract Perilla frutescens fruit oil (PFO) is rich in α-linolenic acid (ALA) and exhibits biological activities. We aimed to investigate analgesic, anti-inflammatory anti-ulcer activities of PFO PFO-supplemented soybean milk (PFO-SM) animal models. Analgesic activity was assessed acetic acid-induced writhing mice, while performed ethyl phenylpropiolate (EPP)-induced ear edema carrageenan-induced hind paw rats. Anti-ulcer effects were conducted water immersion stress, HCl/ethanol...
Ethyl caffeate (EC), octyl caffeate(OC), benzyl caffeate(BC) and phenethyl caffeate(PC) were synthesized evaluated for scavenging of superoxide anion, nitric oxide radical 1,1-diphenyl-1-picrylhydrazyl radical(DPPH). Antioxidant activity was investigated with reducing power method. Pooled human liver microsome used investigating the effects on cytochrome P450 1A2 (CYP1A2) catalytic activities by using phenacetin as a substrate. Dixon Cornish- Bowden plots enzyme kinetic analysis. The EC, OC,...
Caffeic acid (CAF) and its amide analogues, ethyl 1-(3',4'-dihydroxyphenyl) propen (EDPA), phenethyl (PEDPA), phenmethyl 1- (3',4'-dihydroxyphenyl) (PMDPA) octyl (ODPA) were investigated for the inhibition of procarcinogen activating enzyme.CYP1A2 scavenging activity on formation nitric oxide, superoxide anion, DPPH radical hydroxyl radical.It was found that they inhibited CYP1A2 enzyme by uncompetitive inhibition. Apparent Ki values CAF, EDPA, PEDPA, PMDPA ODPA 0.59, 0.39, 0.45, 0.75 0.80...
This study aimed to develop perilla fruit oil (PFO)-fortified soybean milk (PFO-SM), identify its sensory acceptability, and evaluate health outcomes. Our PFO-SM product was pasteurized, analyzed for nutritional value, had acceptability assessed by an experienced trained descriptive panel (n = 100) based on a relevant set of attributes. A randomized clinical trial conducted involving healthy subjects who were assigned consume deionized water (DI), SM, PFO-SM, or black sesame-soybean (BS-SM)...
Iron fortifications are used for the treatment of iron-deficiency anemia; however, iron dosing may cause oxidative damage to gut lumen. Thai Sinlek rice is abundant in and contains phytochemicals. We aimed at evaluating effect an iron-rice (IR) hydrolysate drink (100 mL/serving) on neurological function, red cell indices status elders. Healthy elderly subjects were divided into three non-anemic groups one anemic group. The consumed WR (2 mg iron/serving) two IR drinks (15 27 (groups A, B D,...
Inhibition of acetylcholinesterase (AChE) and prevention acetylcholine degradation are the most accepted therapies for Alzheimer's disease. Aqueous extracts seventeen Thai medicinal plants were used in traditional medicine preventing chronic diseases such as diabetes, hypertension cardiovascular diseases. They tested cholinesterase inhibitory properties using Ellman's colorimetric method. The screened their free radical scavenging 1, 1 diphenyl-2-picrylhydrazyl (DPPH), ferric reducing...
Summary We produced the iron rice (IR) drink, determined relevant chemical composition and antioxidant activity tested consumers’ degree of satisfaction. IR grains were digested with α‐amylase analysed activity, while hydrolysate (pH 4.0) flavouring agents added for final preparation drink. The contained a total content 13.9 mg g −1 , phenolic 1.33 ± 0.07 gallic acid equivalent γ‐oryzanol 70.12 2.7 kg grain, all which inhibited generation free radicals in concentration‐dependent manner....