A5048981176- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Tea Polyphenols and Effects
- Malaria Research and Control
- Trace Elements in Health
- Folate and B Vitamins Research
- Phytochemicals and Antioxidant Activities
- Synthesis and biological activity
- Bee Products Chemical Analysis
- Blood properties and coagulation
- Trypanosoma species research and implications
- Heavy Metals in Plants
- Erythropoietin and Anemia Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Curcumin's Biomedical Applications
- Research on Leishmaniasis Studies
- Biochemical effects in animals
- Mosquito-borne diseases and control
- Drug-Induced Hepatotoxicity and Protection
- Natural Antidiabetic Agents Studies
- Fatty Acid Research and Health
- Ginkgo biloba and Cashew Applications
- Digital Imaging for Blood Diseases
- Synthesis and Biological Evaluation
- Natural Products and Biological Research
Chiang Mai University
2016-2025
Faculty (United Kingdom)
2019
University College London
2017
Background/Objective: Ferroptosis is an iron-dependent form of programmed cell death characterized by lipid peroxidation products (LPOs). A chemotherapeutic drug, 5–fluorouracil (5–FU), can induce epithelial mucositis and favor drug synergism with erastin in ferroptosis. Camellia tea saponin extract (TS) known to exert antioxidative properties. This study aims delineate the protective role TS mitigating 5–FU-induced ferroptosis inflammation human keratinocytes. Methods: HaCaT cells were...
Iron overload in patients with β-thalassemia can cause oxidative organ dysfunction. chelation along antioxidant supplementation ameliorate such complications and prolong lives. Green tea extract (GTE) rich epigallocatechin-3-gallate (EGCG) exhibits anti-oxidation iron properties β-knockout thalassemic (BKO) mice diagnosed overload. We investigated the effects of GTE deferiprone (DFP) alone combination one another, upon levels redox-active iron, lipid-peroxidation product, insulin hepcidin...
A decreased hemoglobin synthesis is contemplated as a pathological indication of β-thalassemia. Recent studies show that EPZ035544 from Epizyme could induce fetal (HbF) levels due to its proven capability inhibit euchromatin histone lysine methyl transferase (EHMT2). Therefore, the development EHMT2 inhibitors considered promising in managing Our strategy find novel compounds are relies on virtual screening ligands have structural similarity...
The most important cause of death in β-thalassemia major patients is organ dysfunction due to iron deposits.
Objectives We have investigated the efficacy of mono- and combined therapy with green tea extract (GTE) in mobilizing redox iron, scavenging reactive oxygen species (ROS), improving insulin production iron-loaded pancreatic cells. Methods Rat insulinoma β-cells were using culture medium supplemented either fetal bovine serum or ferric ammonium citrate treated various doses GTE for epigallocatechin-3-gallate (EGCG) equivalence combination iron chelators. Cellular ROS, secretory measured....
Introduction Elevated ambient pollution exposure is potentially linked to thromboembolism. However, the mechanisms by which particulate matter (PM) interferes with balance of hemostatic system remain unclear. This study investigates PM-mediated changes in individuals across unique seasonal variations pollution. Methods prospective was conducted between February and July 2020 during alterations Chiang Mai, Thailand. Blood tests from 30 healthy subjects were assessed at four-week intervals,...
Background/Objective:Staphylococcus aureus produces staphyloferrin A (Sfna) siderophores to sequester host iron during infection and rapid cell proliferation We examined drug susceptibility, siderophore production, genome sequencing of clinical isolates S. aureus. Methods: total 100 specimens, including pus, sputum, hemoculture, urine, tissue, fluid, skin scrap were grown in iron-deprived Luria broth agar. The investigated for spectral signature using MALDI–TOF/MS, while antibiotic...
ABSTRACT High fat consumption leads to the development of fatty liver or hepatic steatosis, which contributes fibrosis, cirrhosis, and hepatocellular carcinoma. Early intervention is crucial prevent this health issue. Black rice ( Oryza sativa L. indica ) green tea Camellia sinensis var. assamica are traditional Thai supplements known for their antioxidant anti‐inflammatory properties. This study aimed evaluate phytochemical composition, biological activities, anti‐lipid accumulation effect...
We aimed to analyze the chemical compositions in Arabica coffee bean extracts, assess relevant antioxidant and iron-chelating activities extracts instant coffee, evaluate toxicity roasted coffee. Coffee beans were extracted using boiling, drip-filtered espresso brewing methods. Certain phenolics investigated including trigonelline, caffeic acid their derivatives, gallic acid, epicatechin, chlorogenic (CGA) p-coumaroylquinic p-coumaroyl glucoside, rutin syringic that exist green along with...
Abstract Perilla frutescens fruit oil (PFO) is rich in α-linolenic acid (ALA) and exhibits biological activities. We aimed to investigate analgesic, anti-inflammatory anti-ulcer activities of PFO PFO-supplemented soybean milk (PFO-SM) animal models. Analgesic activity was assessed acetic acid-induced writhing mice, while performed ethyl phenylpropiolate (EPP)-induced ear edema carrageenan-induced hind paw rats. Anti-ulcer effects were conducted water immersion stress, HCl/ethanol...
Malaria i a serious health problem caused by Plasmodium spp. that can be treated an anti-folate pyrimethamine (PYR) drug. Deferiprone (DFP) is oral iron chelator used for the treatment of overload and has been recognized its potential anti-malarial activity. Deferiprone–resveratrol hybrids (DFP-RVT) have synthesized to present therapeutic efficacy at level which superior DFP. We focused on determining lipophilicity, toxicity inhibitory effects P. falciparum growth iron-chelating activity...
Chronic liver diseases are complications of thalassemia with iron overload. Iron chelators required to remove excessive iron, and antioxidants supplemented diminish harmful reactive oxygen species (ROS), purposing ameliorate oxidative damage dysfunctions. The deferiprone–resveratrol hybrid (DFP–RVT) is a synthetic chelator possessing anti-β-amyloid peptide aggregation, anti-malarial activity, hepatoprotection in plasmodium-infected mice. study focuses on investigating the antioxidant,...
Iron is essential for all organisms including fast-dividing malarial parasites. Inversely, iron chelators can inhibit parasite growth through the inhibition of DNA synthesis and ameliorate oxidative cell damage. Deferiprone (DFP)-resveratrol (RVT) hybrid (DFP-RVT) a lipophilic anti-oxidative, iron-chelating agent that has displayed potent neuroprotective anti-plasmodium activities in vitro. The goal this work was to investigate inhibitory effects DFP-RVT on stress levels during malaria...
β-Thalassemia is characterized by ineffective erythropoiesis leading to chronic anemia. Thus, increased iron absorption from the duodenum and via blood transfusions required maintain normal hemoglobin (Hb) levels chelators in removal of excessive iron. Certain agents are also needed for improvement stress dysregulation. Green tea extract (GTE), which rich epigallocatechin-3-gallate (EGCG), known possess radical scavenging iron-chelating activities. We aimed assess effects green on erythroid...
Iron is essential for numerous biological processes; however, an iron imbalance can contribute to a number of diseases. An excess accumulate in the body and subsequently induce production reactive oxygen species (ROS), leading oxidative tissue damage organ dysfunction. The liver, major storage site, vulnerable this iron-induced damage; issue be overcome by chelation iron. This study aimed investigate effect 6-gingerol-rich ginger (Zingiber officinale) extract on chelation, antioxidation,...
β-Thalassemia patients suffer from ineffective erythropoiesis and increased red blood cell (RBC) hemolysis. Blood transfusion, erythropoietic enhancement, antioxidant supplementation can ameliorate chronic anemia. Green tea extract (GTE) is comprised of catechin derivatives, which epigallocatechin-3-gallate (EGCG) the most abundant, presenting free-radical scavenging, iron-chelating, erythropoiesis-protective effects. The present study aimed to evaluate effects GTE tablets on primary outcome...
Macaroni is a commercially available Italian food product that popular among consumers around the world. The supplementation of green tea extract (GTE) and turmeric curcumin (TCE) in macaroni may serve as promising beneficial bioactive ingredients. We aimed to produce functional macaroni, assess degree consumer satisfaction study antidiabetic activity diabetic rats. In this study, was fortified with GTE, TCE mixture GTE ratio 1:1, w/w (GTE/TCE). resulting products were then analyzed terms...
Objective: To study the effect of perilla fruit oil against carbon tetrachloride (CCl4)-induced liver damage in rats. Methods: Perilla was analyzed terms fatty acids, tocopherols and tocotrienols using chromatography. Sub-chronic toxicity investigated rats for 90 d followed by a 28 recovery period. Hematological, biochemical pathological parameters were determined. evaluate hepatoprotection, divided into five groups orally administered with Tween 80 10 d; 80, silymarin, (0.1 mL/200 g) (1...
Redox-active iron generates reactive oxygen species that can cause oxidative organ dysfunction. Thus, the anti-oxidative systems in body and certain dietary antioxidants, such as anthocyanins, are needed to control stress. We aimed investigate effects of dielectric barrier discharge (DBD) plasma technology preparation Riceberry™ rice flour (PRBF) on iron-induced stress mice. PRBF using was rich mainly cyanidine-3-glucoside peonidine-3-glucoside. (5 mg AE/mg) lowered WBC numbers dextran...
This study aimed to develop perilla fruit oil (PFO)-fortified soybean milk (PFO-SM), identify its sensory acceptability, and evaluate health outcomes. Our PFO-SM product was pasteurized, analyzed for nutritional value, had acceptability assessed by an experienced trained descriptive panel (n = 100) based on a relevant set of attributes. A randomized clinical trial conducted involving healthy subjects who were assigned consume deionized water (DI), SM, PFO-SM, or black sesame-soybean (BS-SM)...