A5009239531- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
University of North Carolina Health Care
2023-2025
University of North Carolina at Chapel Hill
2021-2025
Abstract The bed nucleus of the stria terminalis (BNST) plays an emerging role in pain regulation. Pharmacological studies have found that inhibiting corticotropin-releasing factor (CRF) signaling BNST can selectively mitigate sensory and affective-motivational components pain. However, mechanistic insight on source CRF drives responses to these harmful experiences remains unknown. In present study, we used a series genetic approaches show is engaged processing modulation We conducted...
Fear responses to perceived danger are critical for survival, as they prompt the individual respond threats and avoid harm. However, excessive fear can impede normal biological processes become harmful. This study investigates neural mechanisms underlying two distinct forms of fear—phasic sustained—in male female mice, with a focus on bed nucleus stria terminalis (BNST) corticotropin-releasing factor (CRF) signaling. Phasic is characterized by immediate clear threats, while sustained driven...
ABSTRACT Fear is a protective response to perceived danger that allows an organism identify and respond threats avoid harm. Though fear critical for survival, excessive can impede normal biological processes; thus, accurate risk assessment key well-being. Here we investigate the neural underpinnings of two distinct behavioral states: phasic sustained fear. Phasic considered adaptive characterized by clear discrete cue dissipates rapidly once threat no longer present. Conversely, or anxiety...
Fear is a protective response to perceived danger that allows an organism identify and respond threats avoid harm. Though fear critical for survival, excessive can impede normal biological processes; thus, accurate risk assessment key well-being. Here we investigate the neural underpinnings of two distinct behavioral states: phasic sustained fear. Phasic considered adaptive characterized by clear discrete cue dissipates rapidly once threat no longer present. Conversely, or anxiety heightened...
Fear is a protective response to perceived danger that allows an organism identify and respond threats avoid harm. Though fear critical for survival, excessive can impede normal biological processes; thus, accurate risk assessment key well-being. Here we investigate the neural underpinnings of two distinct behavioral states: phasic sustained fear. Phasic considered adaptive characterized by clear discrete cue dissipates rapidly once threat no longer present. Conversely, or anxiety heightened...