A5004698218- Stress Responses and Cortisol
- Chinese history and philosophy
- Advancements in Battery Materials
- HIV Research and Treatment
- Polyomavirus and related diseases
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Advanced Battery Technologies Research
- Vietnamese History and Culture Studies
- Monoclonal and Polyclonal Antibodies Research
- Advanced Battery Materials and Technologies
- Multiple Sclerosis Research Studies
- Japanese History and Culture
- Full-Duplex Wireless Communications
- Neuroendocrine regulation and behavior
- Ophthalmology and Visual Impairment Studies
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Advanced battery technologies research
- Sentiment Analysis and Opinion Mining
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Colorectal Cancer Treatments and Studies
- Shakespeare, Adaptation, and Literary Criticism
- COVID-19 epidemiological studies
University of North Carolina at Chapel Hill
2023-2025
John Sealy Hospital
2025
University of North Carolina Health Care
2023-2025
BioSurfaces (United States)
2023-2024
University of Michigan
2023-2024
University of Auckland
2015-2024
The University of Texas MD Anderson Cancer Center
2020-2024
The University of Texas Health Science Center at San Antonio
2024
Georgetown University
2024
Wellesley College
2024
Progressive multifocal leukoencephalopathy (PML) is associated with natalizumab treatment. We quantified the risk of PML in patients multiple sclerosis, according to presence or absence three factors: positive status respect anti–JC virus antibodies, prior use immunosuppressants, and increasing duration
Objective The increased risk of progressive multifocal leukoencephalopathy (PML) with natalizumab treatment is associated the presence anti–JC virus (JCV) antibodies. We analyzed whether anti‐JCV antibody levels, measured as index, may further define PML in seropositive patients. Methods association between serum or plasma levels and was examined antibody–positive multiple sclerosis (MS) patients from clinical studies postmarketing sources. For non‐PML patients, probabilities having an index...
Objective. The complexity of highly active antiretroviral therapy (HAART), with multiple medications, formulations, and dosing intervals, makes adherence challenging. Little is known about the children to HAART. objective this study was identify correlates HAART relationship between outcomes in a pediatric clinical trial. Methods. Pediatric AIDS Clinical Trials Group 377 phase I/II randomized trial 4 regimens antiretroviral-experienced, clinically stable aged months 17 years. treatment arms...
This study analyzed the content of 125 unique reports published since 1990 that have examined health and well-being-as well as interpersonal contextual experiences-of sexual minority youth color (SMYoC). One-half sampled only young men, 73% were noncomparative samples youth, 68% included multiple racial-ethnic groups (i.e., 32% mono-racial/ethnic). Most focused on health-related outcomes mental health, substance use), while substantially fewer attended to normative developmental processes...
Background: The Expanded Disability Status Scale (EDSS) has wide scientific and regulatory precedent but limited ability to detect clinically relevant disability progression in secondary progressive multiple sclerosis (SPMS) patients, partly due a lack of meaningful measurement short-distance ambulatory upper-extremity function. Objective: To present rationale for composite endpoint adding the timed 25-foot walk (T25FW) 9-Hole Peg Test (9HPT) EDSS SPMS assessment. Methods: Using...
Abstract Electrode cross-talk in Li-ion batteries refers to side reactions which soluble products are generated at one electrode and consumed or further reacted the other electrode. While these impact battery lifetime directly, they perhaps have even greater consequence for management systems state-of-health prediction. In this work, we review current literature on mechanisms, classify various as firmly detrimental beneficial cell lifetime, identify future scientific challenges area.
The nickel-catalyzed cross-coupling of an anhydride with organozinc reagent was studied theoretically. energetic span model (Kozuch, S.; Shaik, S. J. Am. Chem. Soc. 2006, 128, 3355; Kozuch, Phys. A 2008, 112, 6032) employed in order to analyze the observed kinetic behavior (Johnson, B.; Bercot, E. A.; Rowley, M.; Coates, G. W.; Rovis, T. 2007, 1298, 2718). computed energy profile, combined model, enables modeling faithfully intriguing experimental findings such as independence rate on...
Previous researches have focused on analyzing emotion through monolingual text, when in fact bilingual or code-switching posts are also common social media.Despite the important implications of for analysis, existing automatic extraction methods fail to accommodate content.In this paper, we propose a general framework construct and analyze emotional media.We first an annotation scheme identify emotions associated with languages expressing them Chinese-English corpus.We then make some...
IgA antibodies have broad potential as a novel therapeutic platform based on their superior receptor-mediated cytotoxic activity, potent neutralization of pathogens, and ability to transcytose across mucosal barriers via polymeric immunoglobulin receptor (pIgR)-mediated transport, compared traditional IgG-based drugs. However, the transition into clinical development has been challenged by complex expression characterization, well rapid serum clearance that is thought be mediated glycan...
The relative potency and tolerability of multidrug regimens used to treat infants children infected with human immunodeficiency virus type 1 (HIV-1) are largely unknown. In Pediatric AIDS Clinical Trials Group (PACTG) Protocol 377, 181 were assigned receive stavudine (d4T) plus nevirapine (NVP) ritonavir (RTV); d4T lamivudine (3TC) nelfinavir (NFV); NVP NFV; or 3TC, NVP, NFV. Eleven additional received NFV given twice daily. All subjects had not previously protease inhibitors nonnucleoside...
Volatile anesthetics are currently believed to cause unconsciousness by acting on one or more molecular targets including neural ion channels, receptors, mitochondria, synaptic proteins, and cytoskeletal proteins. Anesthetic gases isoflurane bind microtubules (MTs) dampen their quantum optical effects, potentially contributing causing unconsciousness. This possibility is supported the finding that taxane chemotherapy consisting of MT-stabilizing drugs reduces effectiveness anesthesia during...
One hundred eighty-one antiretroviral-experienced, protease inhibitor-naive, clinically stable HIV-infected children between 4 months and 17 years of age were randomly assigned to receive one four combination regimens evaluate the change in plasma HIV RNA, safety, tolerance when changing antiretroviral therapy a inhibitor-containing regimen. All contained stavudine; addition received nevirapine plus ritonavir, lamivudine nelfinavir, or nelfinavir. Twelve additional chose stavudine with...
Background There is an unmet need for disease-modifying therapies to improve ambulatory function in disabled subjects with multiple sclerosis. Objectives: Assess the effects of natalizumab on relapsing-remitting sclerosis (RRMS) or secondary progressive (SPMS). Methods We retrospectively reviewed as measured by timed 25-foot walk (T25FW) clinical trial Expanded Disability Status Scale score ≥3.5, including RRMS from phase 3 AFFIRM and SENTINEL trials, relapsing SPMS 2 MS231 study,...
Outer membrane proteins (OMPs) in Gram-negative bacteria are essential for a number of cellular functions including nutrient transport and drug efflux. Escherichia coli BamA is an component the OMP β-barrel assembly machinery potential novel antibacterial target that has been proposed to undergo large (~15 Å) conformational changes. Here, we explored methods isolate anti-BamA monoclonal antibodies (mAbs) might alter function this ultimately lead bacterial growth inhibition. We first...
Abstract Despite decades of intense research, glioma remains a disease for which no adequate clinical treatment exists. Given the ongoing therapeutic failures conventional approaches, nanomedicine may offer alternative options because it can increase bioavailability drugs and alter their pharmacokinetics. Here, new type synthetic protein nanoparticles (SPNPs) is reported that allow effective loading controlled release potent cancer drug, paclitaxel (PTX) – drug so far has been unsuccessful...
An efficient Pd(0)-catalyzed synthesis of 2-cyanoindoles from 2-gem-dihalovinylanilines is reported. Few methods have aimed to synthesize these scaffolds, which are found in many natural products and high bioactivity. This protocol features a robust catalyst system utilizing Zn(TFA)2 prolong the catalytic activity. Additionally, amount cyanide reaction phase minimized by taking advantage solubility Zn(CN)2 two-solvent mixture.
Stable, reproducible, and well-defined reference electrodes are vital for accurate quantification of battery material properties physical mechanisms. Repeated studies have shown sodium metal to be an unreliable electrode in nonaqueous solvents. This work evaluates several alternative chemistries including sodium-tin alloy, nickel hexacyanoferrate carbon. Of the systems tested, non-aqueous silver/silver-ion were yield most stable reproducible voltage measurements.
Abstract Introduction Severe burns trigger hyperinflammatory and hypermetabolic responses, leading to systemic organ damage. High mobility group box 1 (HMGB1) belongs damage associated molecular pattern (DAMPs) which are released from burn wound sites contribute the innate immune system activation. We previously observed that neutralizing circulating HMGB1 mitigated muscle loss in a severely burned rats, we hypothesize protective effect reflects on as well. This study investigated healing...
Fear responses to perceived danger are critical for survival, as they prompt the individual respond threats and avoid harm. However, excessive fear can impede normal biological processes become harmful. This study investigates neural mechanisms underlying two distinct forms of fear—phasic sustained—in male female mice, with a focus on bed nucleus stria terminalis (BNST) corticotropin-releasing factor (CRF) signaling. Phasic is characterized by immediate clear threats, while sustained driven...