A5008556059- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Glaucoma and retinal disorders
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Corneal surgery and disorders
- Cancer Cells and Metastasis
- Retinal Diseases and Treatments
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Geology and Paleoclimatology Research
- Ocular Surface and Contact Lens
- Karst Systems and Hydrogeology
- Proteoglycans and glycosaminoglycans research
- Cancer Research and Treatments
- Intraocular Surgery and Lenses
- Chemokine receptors and signaling
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Cardiac Ischemia and Reperfusion
- Breastfeeding Practices and Influences
- Corneal Surgery and Treatments
- Human-Animal Interaction Studies
- Advanced Neuroimaging Techniques and Applications
- Cardiac Imaging and Diagnostics
Agriculture Victoria Services (Australia)
2025
University of Pennsylvania
2016-2024
Royal Canadian Geographical Society
2024
SIDS Calgary Society
2022
The University of Sydney
2001-2021
Abramson Cancer Center
2016-2020
Northeast Ohio Medical University
2016-2018
Westmead Institute for Medical Research
2018
In-Q-Tel
2016-2018
Rocky Mountain Research Station
2004
Abstract Dense fibrosis and a robust macrophage infiltrate are key therapeutic barriers in pancreatic ductal adenocarcinoma (PDAC). CD40 activation can circumvent these by inducing macrophages, originating from peripheral blood monocytes, to deplete fibrosis. The precise mechanism implications of this antifibrotic activity, though, remain unclear. Here, we report that IFNγ CCL2 released systemically response agonist cooperate redirect subset Ly6C+CCR2+ monocytes/macrophages tumors Whereas is...
Abstract Pancreatic ductal adenocarcinoma (PDAC) ranks fourth among cancer‐related deaths in the United States. For patients with unresectable disease, treatment options are limited and lack curative potential. Preclinical mouse models of PDAC that recapitulate biology human pancreatic cancer offer an opportunity for rational development novel approaches may improve patient outcomes. With recent success immunotherapy subsets solid malignancies, interest is mounting possible use PDAC....
Off-tumor targeting of human antigens is difficult to predict in preclinical animal studies and can lead serious adverse effects patients. To address this, we developed a mouse model with stable tunable Her2 (hHer2) expression on normal hepatic tissue compared toxicity between affinity-tuned chimeric antigen receptor T cells (CARTs). In mice hHer2-high livers, both the high-affinity (HA) low-affinity (LA) CARTs caused lethal liver damage due immunotoxicity. hHer2-low LA-CARTs exhibited less...
The domestic canine (canis familiaris) is a growing novel model for human neuroscientific research. Unlike rodents and primates, they demonstrate unique convergent sociocognitive skills with humans, are highly trainable able to undergo non-invasive experimental procedures without restraint, including fMRI. In addition, the gyrencephalic structure of brain more similar that than rodent models. increasing use dogs neuroscience studies has generating need standard cortical atlas provides common...
Myeloid cells facilitate T cell immune evasion in cancer yet are pliable and have antitumor potential. Here, by cotargeting myeloid activation molecules, we leveraged the compartment as a therapeutic vulnerability mouse models of pancreatic cancer. solid tumors expressed receptors including pattern recognition receptor Dectin-1 TNF superfamily member CD40. In checkpoint inhibitor-resistant cancer, coactivation Dectin-1, via systemic β-glucan therapy, CD40, with agonist antibody treatment,...
Abstract Objective To identify clinical characteristics, bacterial isolates, and their antimicrobial susceptibility patterns in a prospective study of dogs presenting with suspected keratitis to aid selection appropriate therapy. Animals Seventy‐one client‐owned two referral hospitals Australia. Procedure Corneal swabs information were collected from suspect April 2012 December 2014. Cytology bacteriologic culture performed on samples vitro isolates. Results Positive cultures obtained 42 the...
Case series summary A retrospective study was undertaken to review outcomes of keratectomy and corneoconjunctival transposition in cats with superficial deep corneal sequestra. Information including pertinent history, signalment, ophthalmological findings postoperative outcome collected from medical records. Follow-up obtained by clinical examination, contact the referring veterinarians records or telephone owners. Ninety-seven (109 eyes) were included 2005–2015. The most commonly affected...
In cases in which vision cannot be restored and the eye is a source of pain, removal may indicated. mammals, enucleation most common procedure performed; however, due to distinct anatomical features avian eye, evisceration preferred method these species. The large globe size rigid sclera leave bird with sunken socket, cause become unbalanced not cosmetically appealing. Furthermore, birds have short optic nerves that can injured traction thin interorbital septum damaged during surgery....
Abstract Background: Advancements in immunotherapy have opened new avenues for the treatment of solid tumors. However response remains poor, especially case advanced tumors where resistance to after initial a significant challenge. In recent years it has become evident that mechanical properties tumor and immune cells as well microenvironment (TME) pose an upstream challenge efficacy variety therapeutics, including immunotherapy. Approaches such pretreatment with low-dose radiation therapy...
Abstract Objective To evaluate the 350‐mm 2 Baerveldt glaucoma drainage device ( GDD ) in dogs with refractory when modifications to address postoperative hypotony (extraluminal ligature; intraluminal stent) and fibroproliferative response (intraoperative Mitomycin‐C; oral colchicine prednisolone) are implemented as reported human ophthalmology. Design Retrospective case series. Animals Twenty‐eight client‐owned (32 eyes) including seven (nine primary 21 (23 secondary glaucoma. Methods The...
Abstract Objective To compare outcomes following trans‐scleral cyclophotocoagulation ( TSCP ) and 350‐mm 2 Baerveldt implantation in the treatment of canine refractory glaucoma. Design Retrospective case study. Case selection Client owned dogs undergoing surgical glaucoma within a veterinary referral hospital. Procedures Eighty‐six surgeries were performed on 83 eyes (69 dogs) diagnosed with primary or secondary Medical records retrieved, baseline data, surgery, medications, intraocular...
To evaluate the retina and optic nerve head (ONH) in canine eyes predisposed to glaucoma using optical coherence tomography (OCT).Twenty-five (24 dogs).Measures of peripapillary retinal, retinal fiber layer (RNFL), ganglion cell complex (GCC) thickness ONH parameters were obtained vivo by OCT unaffected eye dogs diagnosed with unilateral primary (predisposed; n = 12) compared measures healthy control (normal; 13). Repeatability intrarater reliability explored intraclass correlation...
The Mount Meager Volcanic Complex (Q̓welq̓welústen) is an active glacier-capped volcanic massif in the Garibaldi Belt (British Columbia) and only known glaciovolcanic cave system North America steadily releasing sulfur-rich gases. In September 2022, leveraging specialized explorer expertise, fumarole-carved ice at Job Glacier on Mt. was surveyed. Direct measurements of fumarolic gas concentrations were taken source, with H 2 S >200 ppm, SO >100 CO ∼5,200 ∼230 ppm. Snowpack...
To describe preliminary use of a forced-choice preferential looking task for the clinical assessment vision in dogs.The 18 pet dogs was investigated two separate studies using task: multiple observers watched eye, head and body movements on video recordings to identify cues suggesting when dog had seen feature interest. Human observer reliability determined eight computer-generated stimuli. Visual acuity assessed grating stimuli: real-time, an each dog's eye movement patterns behaviour...
Abstract Objective To describe measurements of in vivo structures the visual pathway beyond retina and optic nerve head associated with canine primary angle‐closure glaucoma (PACG). Methods A prospective pilot study was conducted using magnetic resonance diffusion tensor imaging (DTI) to obtain quantitative measures nerve, chiasm, tract, lateral geniculate nucleus (LGN) dogs without PACG. 3‐Tesla DTI performed on six affected five breed, age‐ sex‐matched controls. indices tracts, LGN were...
Abstract Objective To introduce a protocol for the characterization of protein patterns in tears dogs with primary angle closure glaucoma (PACG) and open‐angle (POAG). Animals Nineteen (25 eyes). Methods Tear samples were collected using Schirmer tear strip, from PACG (PACG‐affected eyes, n = 8; unaffected eyes predisposed to PACG, 7), POAG (n 4), healthy controls 6). Protein precipitation trypsin digestion performed analyses via liquid chromatography‐tandem mass spectrometry. Proteins...
Agonist CD40 antibodies are under clinical development in combination with chemotherapy as an approach to prime for antitumor T cell immunity. However, treatment anti-CD40 is commonly accompanied by both systemic cytokine release and liver transaminase elevations, which together account the most common dose-limiting toxicities. Moreover, increases potential chemotherapy-induced hepatotoxicity. Here, we report a mechanistic link between hepatotoxicity induced when combined show that toxicity...
Glaciovolcanic cave systems, including fumarolic ice caves, can present variable atmospheric hazards. The twin summit craters of Mount Rainier, Washington, USA, host the largest system in world. proximity fumarole emissions these caves to thousands mountaineers each year be hazardous. Herein we first assessment and mapping hazards Rainier along with a discussion on microclimates involved hazard formation persistence. Our results are compared applicable life-safety standards for gas exposure...
This case report describes the clinical findings and ocular pathology in an adult Golden Retriever diagnosed with intraocular sarcoma. Nineteen s prior to diagnosis a lens capsule rupture sarcoma, dog was persistent hyperplastic primary vitreous uveitis based on signs ultrasonographic appearance of eye. Two years after enucleation, there no evidence metastatic spread The immunohistochemical characteristics tumor as well limitations supportive used attempting identify histogenesis are outlined.