A5102811674- Renal cell carcinoma treatment
- Renal and related cancers
- Nanoplatforms for cancer theranostics
- Lymphatic System and Diseases
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Advanced Biosensing Techniques and Applications
- Connective Tissue Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Soft tissue tumor case studies
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Cardiac tumors and thrombi
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Vascular Tumors and Angiosarcomas
- Urologic and reproductive health conditions
- Immunotherapy and Immune Responses
- Health, Medicine and Society
- Angiogenesis and VEGF in Cancer
- Multiple and Secondary Primary Cancers
- Endoplasmic Reticulum Stress and Disease
- Nanoparticle-Based Drug Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- Oral and Maxillofacial Pathology
Inserm
2013-2022
Institut Pasteur
2022
Université Paris Cité
2022
Centre National de la Recherche Scientifique
2017-2021
Centre Antoine Lacassagne
2013-2021
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2013-2021
International University of Monaco
2021
Scientific Centre of Monaco
2021
Université Côte d'Azur
2013-2021
Canadian Nautical Research Society
2013
Sunitinib is an antiangiogenic therapy given as a first-line treatment for renal cell carcinoma (RCC). While improves progression-free survival, most patients relapse. We hypothesized that patient relapse can stem from the development of lymphatic network driven by production main growth factor endothelial cells, VEGFC. In this study, we found sunitinib stimulate vegfc gene transcription and increase VEGFC mRNA half-life. addition, activated p38 MAPK, which resulted in upregulation/activity...
Polo-like kinase 1 (Plk1) expression is inversely correlated with survival advantages in many cancers. However, molecular mechanisms that underlie Plk1 are poorly understood. Here, we uncover a hypoxia-regulated mechanism of Plk1-mediated cancer metastasis and drug resistance. We demonstrated HIF-2-dependent regulatory pathway drives clear cell renal carcinoma (ccRCC). Mechanistically, HIF-2 transcriptionally targets the hypoxia response element promoter. In ccRCC patients, high was to poor...
After birth, the intestine undergoes major changes to shift from an immature proliferative state a functional intestinal barrier. By combining inducible lineage tracing and transcriptomics in mouse models, we identify prodifferentiation PDGFRαHigh stromal originating postnatal LTβR+ perivascular progenitors. The genetic blockage of this increased stem cell pool while decreasing epithelial immune maturation at weaning age, leading reduced growth dysregulated repair responses. Ablating PDGFRα...
HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not.The documents may come from teaching institutions in France abroad, public private centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés. VEGFC acts as...
Degradation of signaling proteins is one the most powerful tumor-suppressive mechanisms by which a cell can control its own growth, survival, and motility. Emerging evidence suggests that autophagy limits several pathways degrading kinases, downstream components, transcription factors; however, this often occurs under stressful conditions. Our recent studies revealed constitutive temporally spatially controls RHOA pathway. Specifically, inhibition autophagosome degradation induces...
HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not.The documents may come from teaching institutions in France abroad, public private centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés. Resistance to...
Abstract Background: Advancements in immunotherapy have opened new avenues for the treatment of solid tumors. However response remains poor, especially case advanced tumors where resistance to after initial a significant challenge. In recent years it has become evident that mechanical properties tumor and immune cells as well microenvironment (TME) pose an upstream challenge efficacy variety therapeutics, including immunotherapy. Approaches such pretreatment with low-dose radiation therapy...
Abstract Introduction: Mastectomy, as treatment or preventative measure for breast cancer, is a critical procedure to reduce cancer risk and manage disease. Postmastectomy reconstruction (PMBR) aims restore physical appearance quality of life but carries significant risks (e.g. 20% chance implant failure) particularly following postmastectomy radiation therapy. While exposure, obesity, diabetes are known contributors, currently there no predictors failure, underscoring crucial gap in...
Sunitinib is one of the first-line standard treatments for metastatic clear cell renal carcinoma (ccRCC) with a median time to progression shorter than 1 year. The objective discover predictive markers response adapt treatment at diagnosis.Prospective phase 2 multi-centre trials were conducted in ccRCC patients initiating sunitinib (54 patients) or bevacizumab (45 setting (SUVEGIL and TORAVA trials). plasmatic level CXCL7 baseline was correlated progression-free survival (PFS).The cut-off...
A fundamental issue in cell biology is how the activation of a signaling pathway should lead to appropriate response. Because their oncogenic potential, abundance, duration and localization key proteins must be carefully controlled. Negative feedback loops that combine transcription protein–protein interactions are among strategies by which can turn off signaling. Our recent studies Cancer Research Autophagy show degradation active such as RHOA-GTP constitutive autophagy represents one...
Signaling, proliferation, and inflammation are dependent on K63-linked ubiquitination—conjugation of a chain ubiquitin molecules linked via lysine 63. However, very little information is currently available about how ubiquitination subverted in cancer. The present study provides, for the first time, evidence that cadmium (Cd), widespread environmental carcinogen, potent activator ubiquitination, independently oxidative damage, activation ligase, or proteasome impairment. We show Cd induces...
Abstract Background: Recently, the successful integration of immunotherapy with other treatment modalities has demonstrated its efficacy in enhancing immune activation and suppressing tumors solid cancers. The most promising such efforts include use low dose radiation (LD-XRT) to prime tumor microenvironment enhance T cell infiltration [Barsoumian HB, et al., 2020; Patel RR, 2021; He K, 2023]. With these advancements, there is an urgent need develop clinical biomarkers predict response...
Abstract Background: Neoadjuvant chemotherapy (NACT) is increasingly used in patients with breast cancer. However, predicting response to NACT remains a challenge everyday clinical practice. Increasing (pre)- and evidence demonstrate the importance of cancer biomechanics mediating therapy response. We others have previously demonstrated that complex biomechanical alterations tissues, can be measured by Atomic Force Microscopy (AFM) at nanoscale level. Incorporating AFM measurements biopsies...
<h3>Background</h3> Low-dose radiation therapy (LD-RT) priming of the tumor microenvironment prior to systemic immunotherapy has emerged as an effective mediator restore response across solid tumors. However, identifying patients who may benefit from such approach remained a significant clinical challenge. Emerging evidence indicates that nanomechanical alterations are viable predictors aggressiveness and treatment response, different We hypothesized stroma remodulation immune activation...
Abstract Degradation of signaling proteins is one the most powerful tumor suppressive mechanisms by which a cell can control its own growth, survival, and motility. Emerging evidence suggests that autophagy limits several pathways degrading kinases, downstream components, transcription factors; however, this often occurs under stressful conditions. We show here constitutive required for fine-tuning RHOA pathway. Specifically, inhibition autophagosome degradation induces accumulation...