Gut microbiota substantially impacts pathogenic and normal immune responses is associated with common chronic diseases. Moreover, it has a considerable effect on the efficacy of cancer therapy. Variant gut linked checkpoint inhibitors, chemo drugs, radiotherapy resistance. Therefore, comprehensive interpretation interactions between therapies required to encourage researchers develop new prevention strategies weaken consequences different therapies. This review discusses modulating role that...

Purpose. Multidrug-resistant Klebsiella pneumoniae is a common nosocomial pathogen that plays an important role in ventilator-associated pneumonia (VAP). This study aimed to define the clonal relatedness of K. strains isolated from paediatric VAP addition those environmental samples. Methodology. included 19 clinical and 4 isolates recovered intensive care unit (PICU) Assiut University Children's Hospital. The were confirmed by biotyping using API strips subjected antimicrobial...

Background: Bacterial infections causing digestive problems are among the most serious threats to Egypt's duck industry, owing their effects on feed utilization and body weight gain. Aim: As a result, goal of this study was identify bacterial pathogens enteritis in ducks as well testing antimicrobials resistance capabilities. Methods: Forty-two flocks from different localities at four Egyptian Governorates (EL-Sharkia, El-Gharbia, El-Dakahlia El-Qaliobia) have been subjected clinical...

The emergence of blaKPC-2 and blaNDM-1 producing Klebsiella pneumoniae represents a great problem in many Egyptian hospitals. One hundred twenty-six K. isolates from patients admitted to Assiut University Hospital were identified by an API20E kit. Carbapenemase-producing (CPKP) was detected the modified carbapenem inactivation method (mCIM), EDTA-modified (eCIM), E-test. Based on polymerase chain reaction, all negative for bla-VIM-1 bla-IMP-1, fifteen these positive both blaNDM-1, two only,...

Background: Medical curriculum reform requires quality assurance in all curricular activities including assessment. Such necessitates a shift of focus from summative assessment (SA) to formative (FA). However, the implementation FA confronts several challenges that hinder its proper application, especially with increased number students and diversity required faculty members. Therefore, this study aims explore perception, implementation, facing members during application undergraduate...

Taxane-induced peripheral neuropathy (TIPN) among breast cancer patients is considered one of the most devastating side effects affecting compliance to chemotherapy protocol and patients' quality life (QOL).This trial aimed evaluate effect lidocaine infusion vs oral duloxetine on incidence severity TIPN QOL in with scheduled for neoadjuvant taxane therapy (TT).Prospective, randomized, single-blinded, controlled trial.This study was carried out 60 12 weeks TT at Medical Research Institute...

Purpose: To evaluate the antimicrobial effect of chitosan as root canal irrigant on Enterococcus faecalis in comparison to 3%NaOCL experimentally infected primary anterior canals. Materials and methods: Access cavity mechanical preparation canals 30 extracted teeth which were then sterilized at autoclave 1210 for 15 minutes. These inoculated with reference strain ATCC 19433.Then grouped into three groups irrigated 3%NaOCl, 0.5% saline respectively. Samples cultured bile auscline agar...

Background: Injury of the kidney due to ischemia-reperfusion (IR) provokes damage in remote organs.The anti-inflammatory and antioxidant activities colchicine have previously been proven.Objective: This study planned assess renal cardiac dysfunctions during different reperfusion intervals after ischemia explore protective effect focusing on role Nrf-2/HO-1 axis.Materials Methods: Thirty-two rats divided into four groups (8 rat/group) were used investigate periods reperfusion.Then, another...

A total of 1800 g fresh minced beef were divided into 6 equal groups (3x100 each). Bacilluscereus was inoculated each group with infective dose 29x107 cfu/g. The used natural oils werethyme oil (0.6% and 1%), cinnamon 1%) mixture them (0.4 % from Theinoculated samples stored at 4oC in refrigerator until be used. wereexamined every 24 hours for sensory examination (overall acceptability) B. cereus count. Theexperiment performed triplicate. Thyme (0.6 decreased count cereus(cfu/g)...

Objective:The study was designed to assess, isolate and characterize coagulase-positive S. aureus its enterotoxins, in addition their methicillin resistance contaminating the beef burger hot dog sandwiches purchased from different fast-food restaurants distributed Mansoura city.Design: Observational study.Procedures: A total of 100 meat (50 50 dog) were bacteriologically molecularly analyzed resistance.Results: found 86% overall tested samples, 90% 82% sandwiches, counts 5.3×10 -2.9×10 4 ,...

Ovarian cancer, because it often presents with vague symptoms, is a difficult disease to diagnose at the early stages, especially in developing countries. In Sudan, diagnosis further complicated by additional factors and challenges. First, as any country, access treatment, facilities medical staff generally lacking. Secondly, Sudan second largest country Africa: its very size difficulties for implementation of centralized health system. The two tertiary hospitals or near capital have long...

Glipizide is an oral hypoglycemic agent used in the treatment of type II diabetes mellitus.It characterized by its poor aqueous solubility and delayed absorption with concomitant food intake.The objective present study was to enhance rate glipizide avoid side effects on stomach formulating it into buccoadhesive sustained release disc formulations.The discs were prepared direct compression method.Hydroxypropyl methylcellulose (HPMC 15000), as main hydrophilic matrix forming polymer either...

Agricultural land holdings went through several changes during the period 1929-2010 due to in economic orientations and underpinning policies. The study shows that average area of a holding has declined from 6.13 feddan 1929 about 2.19 2010. However old lands declines 1.93 year 2000 1.61 In contrast new is almost fixed at 9.6-9.7 2000-2010.   To assess inequality distributions  estimated Gini   coefficients for agricultural censuses.  Gini were rather high years 1929, 1939 1950 with...

Background: Calculation of medication dosages can be the challenging for nursing students.Nurse educators are able to design and develop effective methods that consider cognitive structures how mind processes information teach pediatric content students.The aim study was compare between two teaching strategies drug dosage calculation among under graduating students Research design: A quasi-experimental research design.Sample: Ninety in third academic year who were studying course divided...

Spreading of NDMI-producing klebsiella pneumoniaehas become a great trouble in many Egyptian hospitalized patients. Localizing the source these isolates is an important step to prevent their spread this country. This study included 33 pneumoniae that collected from different clinical specimens patients admitted wards at Assiut University Hospitals Egypt and confirmed produce blaNDM1 gene by polymerase chain reaction. Isolates were typed Enterobacterial Repetitive Intergenic Consensus (ERIC)....

Background: Essential oils and their fragrance compounds are a very important part of industry.Geranium extracts used in numerous health disorders medical conditions has been validated as commercial exploitation many industrial branches.Aim: Test the effect geranium extract against spoilage pathogenic bacteria, test if it can be for development novel systems food preservation.Materials Methods: Geranium steam n-Butanol were natural flavor products.Results: The selected sanitizers to reduce...