A5086941926- Photosynthetic Processes and Mechanisms
- Algal biology and biofuel production
- Microbial Community Ecology and Physiology
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Neural dynamics and brain function
- Genomics and Phylogenetic Studies
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Metabolomics and Mass Spectrometry Studies
- Spatial Neglect and Hemispheric Dysfunction
- ATP Synthase and ATPases Research
- Peroxisome Proliferator-Activated Receptors
- Cognitive Abilities and Testing
- Traditional Chinese Medicine Analysis
- Hemispheric Asymmetry in Neuroscience
- EEG and Brain-Computer Interfaces
- Glycosylation and Glycoproteins Research
- Mental Health Research Topics
- Genetic Associations and Epidemiology
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- Dementia and Cognitive Impairment Research
Xuzhou Medical College
2015-2025
Institute of Genetics and Developmental Biology
2016-2024
Chinese Academy of Sciences
2016-2024
Lianyungang Runzhong Pharmaceutical (China)
2021
Shandong University
2009-2018
Shandong Provincial QianFoShan Hospital
2018
State Key Laboratory of Microbial Technology
2014-2017
First Affiliated Hospital of Harbin Medical University
2014-2015
Harbin Medical University
2014-2015
Affiliated Hospital of Xuzhou Medical College
2015
Abstract White matter (WM) asymmetries of the human brain have been well documented using diffusion tensor imaging (DTI). However, relationship between WM asymmetry pattern and cognitive performance is poorly understood. By means tract‐based spatial statistics (TBSS) voxel‐based analyses whole brain, this study examined correlations integrity/asymmetries three distinct components attention, namely alerting, orienting, executive control (EC), which were assessed by attention network test...
Both neuropsychological and functional neuroimaging studies have identified that the posterior parietal lobe (PPL) is critical for attention function. However, unique role of distinct cortical subregions their underlying white matter (WM) remains in question. In this study, we collected both magnetic resonance imaging diffusion tensor (DTI) data normal participants, evaluated performance using network test (ANT), which could isolate three different components: alerting, orienting executive...
Polyunsaturated fatty acids (PUFAs), which contain two or more double bonds in their backbone, are the focus of intensive global research, because nutritional value, medicinal applications, and potential use as biofuel. However, ability to produce these economically important compounds is limited, it both expensive technically challenging separate omega-3 polyunsaturated (ω-3 PUFAs) from natural oils. Although biosynthetic pathways some plant microalgal ω-3 PUFAs have been deciphered,...
Functional neuroimaging studies have indicated the involvement of separate brain areas in three distinct attention systems: alerting, orienting and executive control (EC). However, structural correlates underlying remains unexplored. Here, we utilized graph theory to examine neuroanatomical substrates systems measured by network test (ANT) 65 healthy subjects. White matter connectivity, assessed with DTI deterministic tractography was modeled as a comprising 90 nodes defined Automated...
The default mode network (DMN) is thought to reflect endogenous neural activity, which considered as one of the most intriguing phenomena in cognitive neuroscience. Previous studies have found that key regions within DMN are highly interconnected. Here, we characterized genetic influences on causal or directed information flow during resting state. In this study, recruited 46 pairs twins and collected fMRI imaging data using a 3.0 T scanner. Dynamic modeling was conducted for each...
Abstract Photosynthesis and the biosynthesis of many important metabolites occur in chloroplasts. In these semi-autonomous organelles, chloroplast genome encodes approximately 100 proteins. The remaining proteins, close to 3,000, are encoded by nuclear genes whose products translated cytosol imported into However, there is still no consensus on composition protein import machinery including its motor proteins how newly refolded. this study, we have examined function orf2971, largest gene...
Various polyunsaturated fatty acids, especially gamma-linolenic acid (GLA), inhibit the growth of a variety tumor cells. Some evidence indicates that can kill cells by apoptosis. In current study, we tested apoptotic effect GLA on human chronic myelogenous leukemia K562 induced cell death in dose-dependent manner. Typical nuclei were shown staining with DNA-binding fluorochrome Hoechst 33342, characterized chromatin condensation and nuclear fragmentation. Flow cytometric analysis also...
ABSTRACT Morphological observation and measurements of endocasts have played a vital role in research on the evolution human brain. However, never been used to investigate how brain has evolved since Neolithic period. We investigated during Holocene by comparing virtual from Beiqian site (a Chinese site) sample modern‐day humans. Standardized indices were taken provide quantification overall endocast shape, including length, breadth, height, frontal ratio breadth as well cranial capacity....
It has been widely accepted that attention can be divided into three subnetworks - alerting, orienting and executive control (EC), the of are linked to distinct brain regions. However, association between specific white matter fibers is not clear enough. Using diffusion tensor imaging (DTI), connectivity related performance was assessed by network test (ANT) in 85 healthy adolescents. Tract-based spatial statistics (TBSS) probabilistic tractography analysis demonstrated cerebellothalamic...
The histidine kinase Hik33 plays important roles in mediating cyanobacterial response to divergent types of abiotic stresses including cold, salt, high light (HL), and osmotic stresses. However, how these functions are regulated by remains be addressed. Using a hik33-deficient strain (Δhik33) Synechocystis sp. PCC 6803 (Synechocystis) quantitative proteomics, we found that depletion induces differential protein expression highly like induced This typically includes downregulation proteins...
We investigated the rate of corpus callosum (CC) atrophy and its association with cognitive decline in early Alzheimer's disease (AD).We used publicly available longitudinal MRI data corresponding to 2 or more visits from 137 subjects characterized using Clinical Dementia Rating (CDR) score. classified these into 3 groups according progression their status: a healthy control group (CDR 0→0, n = 72), decliner 0→0.5, 14) an AD 0.5→0.5/1, 51). measured CC area on midsagittal plane calculated...
Cyanobacteria are a group of oxygenic photosynthetic bacteria with great potentials in biotechnological applications and advantages as models for photosynthesis research. The subcellular localizations the majority proteins any cyanobacteria remain undetermined, representing major challenge using both basic industrial researches. Here, label-free quantitative proteomics, we map 2027 Synechocystis sp. PCC6803, model cyanobacterium, to different compartments generate proteome atlas such...
Carbon metabolism is central to photosynthetic organisms and involves the coordinated operation regulation of numerous proteins. In cyanobacteria, proteins involved in carbon are regulated by multiple regulators including RNA polymerase sigma factor SigE, histidine kinases Hik8, Hik31 its plasmid-borne paralog Slr6041, response regulator Rre37. To understand specificity cross-talk such regulations, we simultaneously quantitatively compared proteomes gene knockout mutants for regulators. A...
Attention is a crucial brain function for human beings. Using neuropsychological paradigms and task-based functional imaging, previous studies have indicated that widely distributed regions are engaged in three distinct attention subsystems: alerting, orienting executive control (EC). Here, we explored the potential contribution of spontaneous activity to by examining whether resting-state could account individual differences attentional performance normal individuals. The images behavioral...
Large-scale quantitative evaluation of the tightness membrane association for nontransmembrane proteins is important identifying true peripheral with functional significance. Herein, we simultaneously ranked more than 1000 photosynthetic model organism Synechocystis sp. PCC 6803 their relative using a proteomic approach. Using multiple precisely and experimentally verified subunits protein complexes as landmarks, found that involved in two-component signal transduction systems transporters...