Type 2 diabetes is characterized by a reduction in insulin function and an increase glucagon activity that together result hyperglycemia. Glucagon receptor antagonists have been developed as drugs for diabetes; however, they often plasma levels induce the proliferation of glucagon-secreting α-cells. We find secreted protein Angiopoietin-like 4 (Angptl4) up-regulated via Pparγ activation white adipose tissue following acute treatment with antagonist. Induction angptl4 Angptl4 supplementation...

Background Premature infants are at risk for severe sepsis and meningitis, both infections associated with high mortality morbidity. Cerebro-spinal fluid (CSF) culture is the gold standard method meningitis diagnosis, but interpretation of biochemical parameters CSF essential moment analysis in order to start appropriate treatment. The main objective this study was determine whether levels beta-2-microglobulin (B2M) were elevated preterm CNS or other inflammatory processes, establish if...

Introduction Cardiac surgery (CS) in pediatric patients induces an overt oxidative stress (OS) response. Children are particularly vulnerable to OS related injury. The immaturity of their organs and antioxidant systems as well the induction cardio-pulmonary bypass (CPB) may have important impact on outcomes. purpose this study was describe response, measured by urinary free 8-iso-PGF2α, infants undergoing CS evaluate relationship between response post-operative clinical Methods Infants with...

Pediatric cardiac surgery induces an increased oxidative stress (OS) response. Increased OS is associated with poor neurologic outcomes in neonatal populations similar patterns of brain injury. We investigated and injury infants undergoing heart surgery. Patients 6 months or younger, without cardiopulmonary bypass (CPB), were included this prospective, observational study. divided into infant (30 days−6 months) (<30 days) groups for analysis. Urine biomarker 8-iso-prostaglandin F2α...

Hypoxic ischemic encephalopathy (HIE) is one of the main causes morbidity and mortality during neonatal period, despite treatment with hypothermia. There evidence that oxidative damage plays an important role in pathophysiology hypoxic-ischemic (HI) brain injury. Our aim was to investigate whether postnatal allopurinol administration combination hypothermia would reduce stress (OS) biomarkers animal model HIE. Postnatal 10-day rat pups underwent unilateral HI moderate severity. Pups were...

Extrapulmonary manifestations of bronchiolitis have been previously studied, with some identifying right ventricle (RV) diastolic/systolic dysfunction. We hypothesized that severe cases would cardiac dysfunction resulting an increase in N-terminal pro-hormone B-type natriuretic peptide (NT-proBNP) values and worse outcomes. Therefore, the objective was to evaluate existence determine its association bronchiolitis.This prospective cohort study included children hospitalized for under 1-year...

Abstract Objectives Patients with a delayed diagnosis of diabetes are more likely to present in diabetic ketoacidosis (DKA). The objective this study was assess the prevalence, risk factors, and consequences missed pediatric diagnoses emergency departments (EDs) potentially leading DKA. Methods Cases children under 19 years old first-time mellitus presenting EDs DKA were drawn from Healthcare Cost Utilization Project database. A total 11,716 cases included. defined by an ED discharge 14 days...

The newborn rabbit is a useful animal model for various pathologies and procedures. Airway management of the complex due to its anatomical characteristics, which further complicated in case newborn. Of different methods advanced airway management, endotracheal intubation less aggressive than tracheostomy, more feasible supraglottic given lack devices such small size. As direct glottis visualization very difficult animals this size, blind presented as an effective alternative, especially...

Aims & Objectives: To determine whether ICU-delirium among infants and preschool-aged children is associated with long-term developmental impairment (LTDI). Methods This a prospective pilot study in patients aged 6-months to 5-years admitted the pediatric ICU regardless of diagnosis. Daily delirium screening occurred for up 14 days all using Preschool Confusion Assessment Method ICU. Baseline status was determined by primary care physician documentation prior critical illness. One year...

P-725 Introduction: People with existing respiratory and cardiac conditions may be more susceptible to the acute effects of air pollutants. We tested this hypothesis using a novel approach: cohort design nested case-control analysis was used measure association between black smoke (BS) mortality rates among subjects previously admitted hospital for an emergency condition, condition or digestive condition. Patients were followed up 15 years but attention restricted pollution. Methods: Three...

Cañizo, Débora; Hadley, Stephanie; Camprubí, Marta; Rodriguez-Fanjul, Javier; Sanchez-de-Toledo, Joan Author Information

Abstract Objective : Assessment of neurobehaviour and visual function newborns with congenital heart disease during post-operative period to identify infants at risk neurodevelopmental impairment. Study design: Prospective study that include 45 underwent cardiac surgery. Newborn Behavioral Observations test (NBO) “ML Battery Optotypes” were used for assessment. Results The median NBO global score was 2.4 [2.1-2.6]. Total days oral morphine [p=0.005] total sedation [p=0.009] strongly related...

Abstract Background and Objectives Pulmonary hypertension has been reported as a crucial factor in the pathophysiology of severe bronchiolitis. The aim this study was to evaluate pulmonary artery pressure (PAP) cardiac function patients with bronchiolitis analyze their correlation clinical outcomes. Methods This prospective cohort examined children admitted for PAP assessed by right ventricle (RV) acceleration/ejection time ratio (AT/ET), isovolumic relaxation time, eccentricity index...

The newborn rabbit is a useful animal model for various pathologies and procedures. Airway management of the complex due to its anatomical characteristics, which further complicated in case newborn. Of different methods advanced airway management, endotracheal intubation less aggressive than tracheostomy, more feasible supraglottic given lack devices such small size. As direct glottis visualization very difficult animals this size, blind presented as an effective alternative, especially...