A5077070416- Malaria Research and Control
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- HIV Research and Treatment
- Research on Leishmaniasis Studies
- Genetics, Bioinformatics, and Biomedical Research
- Cutaneous Melanoma Detection and Management
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- HIV/AIDS drug development and treatment
- Lipid Membrane Structure and Behavior
- Skin Protection and Aging
- melanin and skin pigmentation
- Mitochondrial Function and Pathology
- vaccines and immunoinformatics approaches
- DNA and Nucleic Acid Chemistry
- Advanced Proteomics Techniques and Applications
- Food Allergy and Anaphylaxis Research
- Nonmelanoma Skin Cancer Studies
Barcelona Institute for Global Health
2022-2025
Universitat de Barcelona
2022-2025
Institute for Bioengineering of Catalonia
2023-2025
Universidad de Sonora
2025
Barcelona Institute for Science and Technology
2022
Instituto de Salud Carlos III
2020
ABSTRACT The problems associated with the drugs currently used to treat leishmaniasis, including resistance, toxicity, and high cost of some formulations, call for urgent identification new therapeutic agents novel modes action. aggregated protein dye YAT2150 has been found be a potent antileishmanial compound, half-maximal inhibitory concentration (IC 50 ) approximately 0.5 µM against promastigote amastigote stages Leishmania infantum . encapsulation in liposomes significantly improved its...
Artemisinin, curcumin or quercetin, alone in combination, were loaded nutriosomes, special phospholipid vesicles enriched with Nutriose FM06®, a soluble dextrin prebiotic activity, that makes these suitable for oral delivery. The resulting nutriosomes sized between 93 and 146 nm, homogeneously dispersed, had slightly negative zeta potential (around −8 mV). To improve their shelf life storability over time, vesicle dispersions freeze-dried stored at 25 °C. Results confirmed main...
The second-line antileishmanial compound pentamidine is administered intramuscularly or, preferably, by intravenous infusion, with its use limited severe adverse effects, including diabetes, hypoglycemia, myocarditis and renal toxicity. We sought to test the potential of phospholipid vesicles improve patient compliance efficacy this drug for treatment leishmaniasis means aerosol therapy. targeting macrophages pentamidine-loaded liposomes coated chondroitin sulfate or heparin increased about...
The dynamic phosphorylation of the human RNA Pol II CTD establishes a code applicable to all eukaryotic transcription processes. However, ability these specific post-translational modifications convey molecular signals through structural changes remains unclear. We previously explained that each gene can be modeled as combination n circuits connected in parallel. accesses and, series pulses, matches resonance frequency DNA qubits, enabling it extract genetic information and quantum teleport...
Background/Objectives: Skin cancer is increasingly prevalent. Non-melanoma skin cancers pose a challenge, as most lesions are diagnosed at later stages and often lead to complications. Although dermatoscopy has emerged valuable tool that enhances the confidence of dermatologists, specific patterns for accurately identifying various subtypes non-melanoma have yet be detailed. This study aimed investigate dermatoscopic clues facilitate accurate diagnosis among dark-skinned Mexican individuals....
The dynamic phosphorylation of the human RNA Pol II CTD establishes a code applicable to all eukaryotic transcription processes. However, ability these specific post-translational modifications convey molecular signals through structural changes remains unclear. We previously explained that each gene can be modeled as combination n circuits connected in parallel. accesses and, series pulses, matches resonance frequency DNA qubits, enabling it extract genetic information and quantum teleport...
Background/Objectives: Skin cancer is increasingly prevalent. Non-melanoma skin cancers pose a challenge, as most lesions are diagnosed at later stages and often lead to complications. Although dermatoscopy has emerged valuable tool that enhances the confidence of dermatologists, specific patterns for accurately identifying various subtypes non-melanoma have yet be detailed. This study aimed investigate dermatoscopic clues facilitate accurate diagnosis among Mexican individuals. There...
Abstract Background By 2016, signs of emergence Plasmodium falciparum resistance to artemisinin and partner drugs were detected in the Greater Mekong Subregion. Recently, independent evolution has also been reported Africa South America. This alarming scenario calls for urgent development new antimalarials with novel modes action. We investigated interference protein aggregation, which is potentially toxic cell occurs abundantly all stages, as a hitherto unexplored drug target pathogen....
: YAT2150 is a first-in-class antiplasmodial compound that has been recently proposed as new interesting drug for malaria therapy.