A5047389152- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Nanopore and Nanochannel Transport Studies
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Lipid Membrane Structure and Behavior
- Helicobacter pylori-related gastroenterology studies
- Membrane-based Ion Separation Techniques
- Crystallography and molecular interactions
- Pregnancy and preeclampsia studies
- Gastroesophageal reflux and treatments
- Infant Nutrition and Health
- Supramolecular Chemistry and Complexes
- Membrane Separation Technologies
- Ureteral procedures and complications
- Neonatal and Maternal Infections
- Supramolecular Self-Assembly in Materials
- Genetic Neurodegenerative Diseases
- Infective Endocarditis Diagnosis and Management
- Microfluidic and Capillary Electrophoresis Applications
- Prostate Cancer Treatment and Research
- Advanced biosensing and bioanalysis techniques
- Renin-Angiotensin System Studies
- Breastfeeding Practices and Influences
Université de Montpellier
2014-2024
École Nationale Supérieure de Chimie de Montpellier
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Institut Européen des Membranes
2014-2024
Semmelweis University
2002-2021
University of Cambridge
2019-2021
Centre Occitanie-Montpellier
2015
Babeș-Bolyai University
2014
Division of Chemistry
2014
Magyar Agrár- és Élettudományi Egyetem
2014
Aquaporins (AQPs) are biological water channels known for fast transport (∼10(8)-10(9) molecules/s/channel) with ion exclusion. Few synthetic have been designed to mimic this high permeability, and none reject ions at a significant level. Selective translocation has previously shown depend on water-wires spanning the AQP pore that reverse their orientation, combined correlated channel motions. No quantitative correlation between dipolar orientation of effects proton reported. Here, we use...
Chiral dipolar oriented water wires are observed inside artificial channels embedded in supported bilayer membranes.
Triarylamine molecules appended with crown-ethers or carboxylic moieties form self-assembled supramolecular channels within lipid bilayers. Fluorescence assays and voltage clamp studies reveal that the self-assemblies incorporating crown ethers work as single for selective transport of K+ Rb+. The X-ray crystallographic structures confirm mutual columnar self-assembly triarylamines crown-ethers. dimensional fit cations 18-crown-6 leads to a partial dehydration formation alternating...
Artificial water channels (AWCs) are known to selectively transport water, with ion exclusion. Similarly natural porins, AWCs encapsulate wires or clusters, offering continuous and iterative H-bonding that plays a vital role in their stabilization. Herein, we report octyl-ureido-polyol capable of self-assembly into hydrophilic hydroxy channels. Variants ethanol, propanediol, trimethanol used as head groups modulate the permeabilities, rejection ions. The achieve single-channel permeability...
Abstract Artificial Water Channels (AWCs) have been developed during the last decade with hope to construct artificial analogues of Aquaporin (AQP) proteins. Their osmotic water permeability are in range natural transporters, making them suitable candidates that can potentially transport at lower energy and operating cost. Compared AQPs, AWCs would several potential advantages, such as improved stability, simple scalable fabrication higher functional density when confined 2D membrane arrays....
The natural KcsA K+ channel, one of the best-characterized biological pore structures, conducts cations at high rates while excluding Na+ cations. channel is primordial inspiration for design artificial channels. Important progress in improving conduction activity and /Na+ selectivity has been achieved with ion-channel systems. However, simple systems exhibiting mimicking biofunctions are unknown. Herein, an ion formed by H-bonded stacks squalyl crown ethers, which highly preferred to...
A series of ureido and bis-ureido derivatives were prepared by reacting histamine with alkyl/aryl-isocyanates or di-isocyanates. The obtained assayed as activators the enzyme carbonic anhydrase (CA, EC 4.2.1.1), due to fact that itself has this biological activity. Although inhibition CAs pharmacological applications in field antiglaucoma, anticonvulsant, anticancer, anti-infective agents, activation these enzymes is not yet properly exploited pharmacologically for cognitive enhancement...
The amount of inflammatory cytokines is a major determinant for the development sepsis in very-low-birth-weight (VLBW) neonates. We investigated whether variants tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-4 receptor alpha-chain, IL-6 and IL-10 genes, associated with altered cytokine production, might influence risk complications VLBW infants. determined presence these genetic dried blood samples 33 septic, 35 infected healthy neonates by PCR RFLP methods analyzed their...
To investigate the periprocedural inflammatory response in patients with isolated aortic valve stenosis undergoing surgical replacement (SAVR) or transcatheter implantation (TAVI) different technical approaches.Patients were prospectively allocated to one of following treatments: SAVR using conventional extracorporeal circulation (CECC, n = 47) minimized (MECC, 15), TAVI either transapical (TA, 15) transfemoral (TF, 24) access. Exclusion criteria included infection, pre-procedural...
"Metal-driven" selection between finite mononuclear and polymeric metallosupramolecular species can be quantitatively achieved in solution a crystalline state via coupled coordination/stacking interactional algorithms within dynamic libraries - DMLs.
In this multi-centre, prospective, non-interventional study, the effectiveness and tolerance of ferric carboxymaltose (ferinject®; FCM) was tested through use in standard gynaecological practice. total, data from 273 patients evaluated. 193 these displayed iron deficiency anaemia (IDA), 68 had without (ID). The reasons for ID/IDA were hypermenorrhoea (HyM) (n = 170), post-partum condition (PP) 53) or another indication 53). average age 40 years old, with 8 % them being vegetarians. Half...
The authors tested 123 genotypes described in 54 papers published the journal Neurology between 1999 and 2002 to ascertain whether these genotype distributions deviated from Hardy-Weinberg equilibrium (HWE). Unreported deviations HWE 19 11 of were discovered. also report additional information that could have been extracted after calculating conclude values should be mandatory population genetic studies Neurology.
Previous studies indicated that elevated tumour necrosis factor‐alpha (TNF‐α) levels may play a role in the development of necrotizing enterocolitis (NEC). The A –238 and variants promoter region TNF‐α gene are reportedly associated with altered production. aim our study was to determine impact these polymorphisms on course NEC very‐low‐birthweight (VLBW) infants. Dried blood samples from 46 VLBW neonates were analysed using method restriction fragment length polymorphism. Samples 90 without...
Previous studies indicated that elevated tumour necrosis factor-alpha (TNF-alpha) levels may play a role in the development of necrotizing enterocolitis (NEC). The A(-308) and A(-238) variants promoter region TNF-alpha gene are reportedly associated with altered production. aim our study was to determine impact these polymorphisms on course NEC very-low-birthweight (VLBW) infants. Dried blood samples from 46 VLBW neonates were analysed using method restriction fragment length polymorphism....
An external redox signal delivered by ascorbic acid was used to trigger membrane translocation in a synthetic transduction system.
TPA propellers appear to be compatible with the general requirements for amplified chiral supramolecular rulers used determine number of base pairs short ssDNAs.