A5019772554- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Research on Leishmaniasis Studies
- Marine Biology and Environmental Chemistry
- Microbial Community Ecology and Physiology
- Marine Invertebrate Physiology and Ecology
- Venomous Animal Envenomation and Studies
- Genomics and Phylogenetic Studies
- Microbial Metabolic Engineering and Bioproduction
- Algal biology and biofuel production
- Chemical synthesis and alkaloids
- Neurotransmitter Receptor Influence on Behavior
- Crystallography and molecular interactions
- Marine Toxins and Detection Methods
- Psychedelics and Drug Studies
University of South Florida
2012-2022
A new rearranged spongian diterpene, darwinolide, has been isolated from the Antarctic Dendroceratid sponge Dendrilla membranosa. Characterized on basis of spectroscopic and crystallographic analysis, central seven-membered ring is hypothesized to originate a ring-expansion precursor. Darwinolide displays 4-fold selectivity against biofilm phase methicillin-resistant Staphylococcus aureus compared planktonic may provide scaffold for development therapeutics this difficult treat infection.
From the CH2Cl2 extract of Antarctic sponge Dendrilla antarctica we found spongian diterpenes, including previously reported aplysulphurin (1), tetrahydroaplysulphurin-1 (2), membranolide (3), and darwinolide (4), utilizing a CH2Cl2/MeOH extraction scheme. However, extracts also yielded diterpenes bearing one or more methyl acetal functionalities (5-9), two which are unreported, while others revised here. Further investigation diterpene reactivity led to additional new metabolites (10-12),...
There is considerable evidence from the literature that psychedelics, such as N,N-dimethyltryptamine (DMT), are safe and effective treatments for depression. However, clinical administration to induce psychedelic effects expensive psychotherapy-assisted likely limit accessibility average patient. emerging DMT promotes positive behavioral changes in vivo at sub-hallucinogenic dosages, depending on target indication, subjecting patients high, bolus dosages may not be necessary. Due rapid...
Abstract The western Antarctic Peninsula harbours a diverse benthic marine community where dense canopies of macroalgae can dominate the shallow subtidal zone (0–40 m or greater). In lower portion this range (below 25–35 depending on topography), invertebrates such as sponges and echinoderms be found in greater abundance due to reduced competition for space from algal species. Dendrilla antarctica (previously membranosa ) is common demosponge that thrives both communities known producing...
Leishmaniasis is a neglected tropical disease that affects nearly one million people per year and can be fatal if left untreated. In screening program, the Antarctic sponge Dendrilla membranosa was found to produce diterpenoid secondary metabolites with activity against leishmaniasis-causing parasite Leishmania donovani. Dichloromethane/methanol (1:1) extracts of yielded aplysulphurin, its tetrahydro- derivative, suite membranolides, some which displayed potent bioactivity. an investigation...
Abstract Darwinolide (I) shows cytotoxic activity.
The sponge Dendrilla membranosa is common on the benthos around Western Antarctic Peninsula (WAP) and easily recognized by its yellow cactus-like bulbs. Chemical defenses are employed D. many other sessile marine invertebrates to deter predation fouling. Diterpenoids, like aplysulphurin membranolide, have been reported as feeding deterrents against known predators. samples collected at various depths from Alan's Wall, Bonaparte, Gamage Point North Laggard Palmer Station, Antarctica. Crude...
Microorganisms are a rich source of bioactive natural products beneficial in drug discovery. Competitive interactions prominent factor secondary metabolite production. However, typical isolated cultivation techniques do not harness the complete chemical diversity found their environment. Recently, microbial mixed fermentations have been employed to increase yields previously described metabolites and induce production novel metabolites. Isolation marine endophytic fungus from Xestospongia...