A5038994303- Autophagy in Disease and Therapy
- Cellular Mechanics and Interactions
- Nuclear Structure and Function
- Cellular transport and secretion
- RNA Research and Splicing
- Biotin and Related Studies
- Lysosomal Storage Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Skin and Cellular Biology Research
- Genomics and Chromatin Dynamics
- Lipid metabolism and biosynthesis
- Cannabis and Cannabinoid Research
- Neuroscience of respiration and sleep
- Thermal Regulation in Medicine
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Neonatal and fetal brain pathology
- Endoplasmic Reticulum Stress and Disease
University of Iceland
2020-2024
National University Hospital of Iceland
2024
Centre de Recherche en Cancérologie de Marseille
2019-2021
Inserm
2018-2021
Aix-Marseille Université
2018-2021
Centre National de la Recherche Scientifique
2021
Génétique Médicale & Génomique Fonctionelle
2017
PINK1, mutated in familial forms of Parkinson's disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically mice as loss PINK1 does not alter basal levels most tissues. To further characterize vivo, we used mito-QC which was combined with the mitochondrial-associated POLGD257A mutation. We focused on skeletal muscle gene expression data indicates that tissue has highest levels. found oxidative hindlimb significantly...
The type V intermediate filament lamins are the principal components of nuclear matrix, including lamina. Lamins divided into A-type and B-type, which encoded by three genes, LMNA, LMNB1, LMNB2. alternative splicing LMNA produces two major lamins, lamin A C. Previous studies have suggested that involved in cancer development progression. been proposed as biomarkers for diagnosis, prognosis, and/or follow-up. aim present study was to investigate cells from metastatic pleural effusions using...
The mild hypothermia response (MHR) maintains organismal homeostasis during cold exposure and is thought to be critical for the neuroprotection documented with therapeutic hypothermia. To date, little known about transcriptional regulation of MHR. We utilize a forward CRISPR-Cas9 mutagenesis screen identify histone lysine methyltransferase SMYD5 as regulator represses key MHR gene SP1 at euthermia. This repression correlates temperature-dependent levels H3 26 trimethylation (H3K36me3) locus...
Abstract Metastatic progression is the leading cause of mortality in breast cancer. Invasive tumor cells develop invadopodia to travel through basement membranes and interstitial matrix. Substantial efforts have been made characterize molecular composition. However, their full identity still missing due difficulty isolating them. To fill this gap, we developed a non-hypothesis driven proteomic approach based on BioID proximity biotinylation technology, using invadopodia-specific protein...
Regulation of microtubule dynamics by plus-end tracking proteins (+TIPs) plays an essential role in cancer cell migration. However, the +TIPs invasion has been poorly addressed. Invadopodia, actin-rich protrusions specialized extracellular matrix degradation, are for and metastasis, leading cause death breast cancer. We, therefore, investigated End Binding protein, EB1, a major hub +TIP network, invadopodia functions. EB1 silencing increased degradation cells. This was recapitulated...
ABSTRACT Macroautophagy/autophagy is an essential catabolic process that targets a wide variety of cellular components including proteins, organelles, and pathogens. ATG7, protein involved in the autophagy process, plays crucial role maintaining homeostasis can contribute to development diseases such as cancer. ATG7 initiates by facilitating lipidation ATG8 proteins growing autophagosome membrane. The noncanonical isoform ATG7(2) unable perform lipidation; however, its regulation function...
In lung adenocarcinoma, low lamin A expression in pleural metastatic cells has been proposed as a pejorative factor. miR-9 physiologically inhibits the of neural and seems to be central actor carcinogenesis process cancer. Thus, it could good candidate explain reduction adenocarcinoma cells. was analyzed 16 effusions containing from significantly reduced patients ‘Low expression’ group compared ‘High group. Then, carcinoma selection by fluorescence-activated cell sorting (FACS) performed...
Abstract PINK1, mutated in familial forms of Parkinson’s disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically mice as loss PINK1 does not alter basal levels most tissues. To further characterize vivo , we used mito -QC which was combined with the mitochondrial-associated POLG D257A mutation. We focused on skeletal muscle gene expression data indicates that tissue has highest levels. found oxidative hindlimb...
ABSTRACT Metastatic progression is the leading cause of mortality in breast cancer. Invasive tumor cells develop invadopodia to travel through basement membranes and interstitial matrix. Substantial efforts have been made characterize molecular composition. However, their full identity still missing due difficulty isolating them. To fill this gap, we developed a non-hypothesis driven proteomic approach based on BioID proximity biotinylation technology, using invadopodia-specific protein...
The E1-like enzyme ATG7 belongs to a group of ATG proteins that mediate the autophagy process. Autophagy is highly conserved degradation pathway important for maintaining homeostasis in eukaryotic cells. Here, we study evolution E1 enzymes and specifically describe region emerged early vertebrates. This vertebrate-specific (VSR) situated within adenylation domain protein, which most prokaryotic origin. A comparative analysis revealed unique this respect, as other family members from yeast...