A5084212512- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Hepatitis B Virus Studies
- Genetic diversity and population structure
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Allergic Rhinitis and Sensitization
- Cancer-related molecular mechanisms research
- Contact Dermatitis and Allergies
- Avian ecology and behavior
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Ferroptosis and cancer prognosis
- Spondyloarthritis Studies and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Genetic and phenotypic traits in livestock
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Cancer Mechanisms and Therapy
- Animal Behavior and Reproduction
- Extracellular vesicles in disease
- Pharmaceutical and Antibiotic Environmental Impacts
- Wildlife Ecology and Conservation
Nanchong Central Hospital
2024
North Sichuan Medical University
2024
University of Missouri
2024
Hebei Medical University
2024
Fourth Hospital of Hebei Medical University
2024
Nanjing Institute of Geography and Limnology
2023-2024
Hebei University
2023-2024
Hebei Agricultural University
2024
Nanjing Medical University
2021-2023
Jiangsu Province Hospital
2021-2023
Metastasis is a key feature of malignant tumors and significantly contributes to their high mortality, particularly in hepatocellular carcinoma (HCC). Therefore, it imperative explore the mechanism tumor metastasis. Recently, tumor-associated macrophages (TAMs) have been demonstrated promote progression, while TAM-derived molecules involved HCC metastasis warrant further investigation.THP-1 was treated with IL-4 (Interleukin-4) IL-13 (Interleukin-13) for M2 polarized macrophages. Exosomes...
Chronic skin diseases, such as atopic dermatitis and psoriasis, are known to affect quality of life by heightening psychological distress. Knowledge about factors contributing distress is essential for supporting physicians in diagnostic multidisciplinary treatment options patients psychologically at risk.To examine whether generic physical, social relevant with chronic diseases might contribute adults psoriasis dermatitis.Self-report data on clinical status, physical symptoms itching...
Abstract Background People with chronic hepatitis B (CHB) commonly experience social and self-stigma. This study sought to understand the impacts of CHB-related stigma a functional cure on stigma. Methods Adults CHB wide range age education were recruited from 5 countries participated in 90-minute qualitative, semi-structured interviews explore concepts related CHB-associated its impact. Participants answered open-ended concept-elicitation questions regarding their self-stigma, potential...
Abstract Objective and design To elucidate Sirt1’s role in gouty arthritis inflammation its potential mechanisms. Material Constructed murine models of conducted THP-1 cell experiments. Treatment 1 mg MSU crystals injected into mice ankle joints for a 72-h intervention. After 3-h pre-treatment with Sirt1-specific inhibitor (EX527) agonist (SRT2104), was induced 21 h using lipopolysaccharide (LPS) plus crystals. Methods We assessed severity through joint index, swelling, hematoxylin eosin...
Background: The experience of stigmatization is a problem frequently recognized in chronic skin diseases such as psoriasis and atopic dermatitis. purpose the study was to investigate broad spectrum physical, psychological social predictors for perceived patients with Patients Methods: Stigmatization experience, demographic variables, age onset, clinical status, physical symptoms itch fatigue, impact disease on daily life, illness cognitions helplessness acceptance, support were recorded...
Abstract: The term 'hand dermatitis' describes inflammatory skin condition localized to the hands. Nurses working at hospital settings are prone develop hand dermatitis. current study aimed evaluate whether certain genetic polymorphisms were associated with development of atopic eczema or non-atopic dermatitis in Taiwanese population. Kaohsiung Medical University Hospital recruited. Atopic eczema, and normal control groups identified. serine protease inhibitor Kazal type 5 (SPINK5),...
Abstract Background Psoriasis is an important systemic inflammatory disease that often leads to severe vascular diseases. This study was launched determine if joint involvement affects incidence of comorbidities in psoriatic patients. In addition, potential vasculo‐protective effects methotrexate patients were also evaluated. Method A population‐based retrospective cohort conducted using the Taiwanese National Health Insurance database spanning from 1996 2006. Accordingly, 7648 and 284...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most malignant cancers in world. The effect preoperative transarterial chemoembolization (TACE) for resectable HCC still controversial and cost‐associated treatments are unknown. Methods We retrospectively compared clinical outcomes resource utilization after liver resection between patients who underwent TACE (TACE‐LR group, n = 114) those did not (LR 236). Results overall mortality rate was 27.54% LR group versus 39.47%...
Synergistic effect refers to simultaneous actions of separate factors which have a greater total than the sum individual factor effects. However, there has been limited knowledge on how synergistic effects occur and roles different drivers are not often considered. Therefore, it becomes quite challenging manage multiple threatening processes simultaneously in order mitigate biodiversity loss. In this regard, our hypothesis is, if traits actually play interaction, conservation efforts could...
Background: Hand eczema is a commonly encountered occupational disease and has negative impact on life quality. Objective: This study aimed to identify the specific conditions that may pose higher risk for occurrence of hand evaluate Method: Nursing staff from university hospital were invited participate in cross‐sectional study. Validated questionnaires quality used point prevalence determine impacts eczema, respectively. Results: The overall response rate was 93%, equivalent 1132 completed...
The hepatitis B-X (HBx) protein is strongly associated with hepatocellular carcinoma. It implicated not to directly cause cancer but play a role in carcinoma as co-factor. oncogenic potential of HBx primarily lies its interaction transcriptional regulators resulting aberrant gene expression and deregulated cellular pathways. Utilizing ultraviolet irradiation simulate tumor-initiating event, we integrated chip-based chromatin immunoprecipitation (ChIP-chip) microarray profiling identified 184...
Background. Nurses are prone to develop hand dermatitis. Although an atopic constitution has been identified as a genetic risk factor, the behavioural factors associated with dermatitis in wet work conditions have not fully explored. Objectives. This study aimed clarify impact of eczema (fulfilling diagnostic criteria during past 1 year) on occurrence and identify among non-atopic nurses Methods. From August 2007 July 2009, from Kaohsiung Medical University Hospital were recruited. The...
Psoriasis is a chronic inflammatory disease. The aim of this study was to evaluate the effects methotrexate and retinoid on risks for developing cerebrovascular disease among psoriatic patients. A population-based nested case-control conducted using Taiwanese National Health Insurance database. Cox proportional hazards models were adopted. hazard ratio (HR) newly developed 1.28 (95% confidence interval (CI) = 1.162-1.413; p < 0.0001) vs. non-psoriatic subjects. In terms or occurrence...
Background and Aims: The poor outcomes of hepatocellular carcinoma (HCC) patients may be due to not only malignant tumors but also limited liver function. Therefore, as stated in major guidelines, with relatively normal function (Child-Pugh A) would referred for curative hepatectomy. Even so, the postsurgery survival rate is still extremely poor. Direct resection benefit most patients. This study aimed improve prognosis predicting accuracy Child-Pugh scoring system.
Lymph node metastasis (LNM) is a well-established prognostic factor for intrahepatic cholangiocarcinoma (ICC), but there are still some controversies relating to the evaluation of nodal status. Therefore, we investigated role lymph dissection (LND), compared performances different staging systems, and then developed validated nomogram predict cancer-specific survival (CSS) ICC patients.The study cohort was taken from Surveillance, Epidemiology, End Results database. Akaike information...
Background Hepatocellular carcinoma (HCC) is a highly heterogeneous tumor with several rare pathological subtypes and which still poorly understood. This study aimed to describe the epidemiological clinical spectrum of five HCC develop competing risk nomogram for cancer-specific survival prediction. Methods The cohort was recruited from Surveillance, Epidemiology, End Results database. clinicopathological data 50,218 patients histologically diagnosed classic (ICD-O-3 Histology Code =...
The evaluation of the nodal status hepatocellular carcinoma (HCC) is a classic but controversial topic. This study aimed to investigate incidence lymph node metastasis (LNM), explore role dissection (LND), and develop validate novel model predict LNM in patients with HCC, not other specified (NOS).The cohort was taken from Surveillance, Epidemiology, End Results database. annual percent change (APC) calculated using Joinpoint regression. Survival analyses adopted competing risk model....
Abstract Background Psoriasis is a systemic disease associated with metabolic disorders and vascular complications. Both psoriasis are inflammation. We hypothesized that the sequence of events between onset disorder may affect risk for subsequent development Methods Nested case–control study was performed using Taiwan National Health Insurance database. Accordingly, total 8180 psoriatic patients 163 600 controls were included. considered as initiator inflammatory march if disorder, including...
Background and Aims: Non-invasive evaluation of liver necroinflammation in patients with chronic disease is an unmet need clinical practice. The diagnostic accuracy transient elastography-based stiffness measurement (LSM) for fibrosis could be affected by necroinflammation, the latter which intensify liver. Such results have prompted us to explore diagnosis potential LSM inflammation. Methods: Three cross-sectional cohorts biopsy-proven were enrolled, including 1417 hepatitis B (CHB) from 10...
Serine/threonine kinase 39 (STK39) is overexpressed in various tumor tissues and plays an essential role progression. In this study, we investigated the clinical value, as well potential functions mechanisms of STK39 cholangiocarcinoma (CCA). The results showed that was CCA negatively associated with prognosis patients CCA. Functionally, knockdown suppressed cell proliferation, migration, invasion, while overexpression facilitated aggressiveness. tumor-promoting effects were also validated...
Abstract Populations of Eurasian otters Lutra lutra , one the most widely distributed apex predators in Eurasia, have been depleted mainly since 1950s. However, a lack information about their genomic diversity and how they are organized geographically East Asia severely impedes our ability to monitor conserve them particular management units. Here, we re‐sequenced analyzed 20 otter genomes spanning continental Asia, including population at Kinmen, small island off Fujian coast, China. The...