A5101713763- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Endometriosis Research and Treatment
- Metabolism, Diabetes, and Cancer
- Reproductive System and Pregnancy
- Hepatitis B Virus Studies
- Ion Transport and Channel Regulation
- Asthma and respiratory diseases
- Peripheral Neuropathies and Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peripheral Nerve Disorders
- Cardiovascular and exercise physiology
- Endoplasmic Reticulum Stress and Disease
- Ion Channels and Receptors
- Pregnancy and preeclampsia studies
- Reproductive Biology and Fertility
- Reconstructive Surgery and Microvascular Techniques
- Multiple Sclerosis Research Studies
- Reconstructive Facial Surgery Techniques
- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Renin-Angiotensin System Studies
- Cardiac Ischemia and Reperfusion
- Hepatitis C virus research
Shanghai Research Institute of Sports Science
2025
Anhui Medical University
2022-2024
First Affiliated Hospital of Anhui Medical University
2024
Qilu Hospital of Shandong University
2024
Xuzhou Medical College
2024
South China Agricultural University
2022-2023
Shenyang 242 Hospital
2023
Nanjing Medical University
2023
Third Affiliated Hospital of Harbin Medical University
2016-2022
Harbin Medical University
2015-2022
The establishment of pregnancy depends on interactions between the epithelial and stromal cells endometrium that drive decidual reaction remodels stroma enables embryo implantation. Decidualization in mice also ovarian hormones presence a blastocyst. Hedgehog signaling is transduced by primary cilia many tissues involved epithelial-stromal cross-talk during decidualization. We found mouse uterine increased number length early were required for In vitro vivo, progesterone promoted...
Decidualization is essential to rodent and primate pregnancy. Senescence increased during decidualization. Failure of senescence clearance decidualization will cause pregnancy abnormality. Caveolin-1 located in plasmalemmal caveolae involved senescence. However, whether caveolin-1 remains undefined. In this study, we examined the expression, regulation function mouse early under human vitro From days 1 8 pregnancy, signals are mainly endothelium myometrium. Estrogen stimulates expression...
This study aims to investigate the effects of low-intensity blood flow restriction training on myocardial tissue in rats. By measuring levels injury biomarkers serum and expression anti-apoptotic antioxidant proteins tissue, preliminarily explores underlying mechanisms. Male 3-month-old Sprague-Dawley rats were randomly divided into following groups: control group (CON), (LIRT), high-intensity (HIRT), (LIBFR), with 6 each group. Body weight, maximum voluntary carrying capacity, morphology,...
Retrospective cross-sectional study.To investigate the differences between tuberculous spondylitis (TS) and brucellar (BS) on magnetic resonance images (MRI).Both TS BS are common spinal affections can cause deformities permanent neurologic deficiencies without prompt diagnosis treatment. However, differentiating types of clinically radiographically is challenging. Despite studies spine infection throughout literature, outcome has not been established. Our study about different...
Nonalcoholic fatty liver disease (NAFLD) affects approximately a quarter of the population worldwide, and persistent overnutrition is one major causes. However, underlying molecular basis has not been fully elucidated, no specific drug approved for this disease. Here, we identify regulatory mechanism that reveals novel function Rab2A in progression NAFLD based on energy status PPARγ. The mechanistic analysis shows nutrition repletion suppresses phosphorylation AMPK-TBC1D1 signaling, augments...
Endometrial decidualization plays a pivotal role during early pregnancy. Compromised has been tightly associated with recurrent implantation failure (RIF). Primary cilium is an antenna-like sensory organelle and acts as signaling nexus to mediate Hh, Wnt, TGFβ, BMP, FGF, Notch signaling. However, whether primary involved in human still unknown. In this study, we found that cilia are present endometrial stromal cells. The ciliogenesis length increased by progesterone vitro vivo...
The treatment of tacrolimus-induced post-transplantation diabetes mellitus (PTDM) has become a hot topic to improve the long-term survival organ transplant patients, however whose pathogenesis not been fully elucidated. In pancreas, up-regulation NF-κB reported stimulate cytokine IL-1β/TNF-α secretion, inducing pancreatic injury, meanwhile other studies have inhibitory effect rapamycin on NF-κB.
Advanced glycation end-products (AGEs) are complex and heterogeneous compounds implicated in diabetes. Sodium reabsorption through the epithelial sodium channel (ENaC) at distal nephron plays an important role diabetic hypertension. Here, we report that H 2 S antagonizes AGEs-induced ENaC activation A6 cells. open probability<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo...
Background and Purpose We have shown that cholesterol is synthesized in the principal cells of renal cortical collecting ducts (CCD) stimulates epithelial sodium channels (ENaC). Here we determined whether lovastatin, a synthesis inhibitor, can antagonize hypertension induced by activated ENaC, following deletion transporter (ATP‐binding cassette A1; ABCA1). Experimental Approach selectively deleted ABCA1 mouse CCD used cell‐attached patch‐clamp technique to record ENaC activity. Western...
Liver steatosis could affect the accuracy of FibroScan in patients with chronic hepatitis B (CHB) and nonalcoholic fatty liver disease (NAFLD). This study aimed to assess cut-off values for diagnosing fibrosis cirrhosis concomitant CHB NAFLD.A total 116 NAFLD who underwent test biopsy were retrospectively enrolled. was staged according METAVIR scoring system. Calculations areas under receiver-operating characteristic curves (AUROC) performed compared staging fibrosis.The AUROCs FibroScan,...
Background Angiotensin‐converting enzyme 3 ( ACE 3) is a recently defined homolog of . However, the pathophysiological function largely unknown. Here, we aim to explore role in pathological cardiac hypertrophy. Methods and Results Neonatal rat cardiomyocytes NRCM s) with gain loss mice global knockout or cardiac‐specific overexpression were used this study. In cultured cardiomyocytes, conferred protection against angiotensin II (Ang )‐induced hypertrophic growth. Cardiac hypertrophy was...
OBJECTIVE Intracerebral hemorrhage (ICH) is a fatal disease with high morbidity and mortality, which may be followed by white matter injury (WMI) due to the local oxidizing reaction induced iron (Fe). In this study, authors examined effect of tetracycline antibiotic minocycline on Fe-induced WMI c-Jun N-terminal kinase (JNK) activation in rats. METHODS Thirty-six male Sprague-Dawley rats underwent an intracaudate injection saline, Fe, or Fe + minocycline. Another 36 had autologous blood were...
There is no effective treatment method for nonalcoholic fatty liver disease (NAFLD), the most common disease. The exact mechanism underlying pathogenesis of NAFLD remains to be elucidated. Here, we report that tumor necrosis factor receptor–associated ubiquitous scaffolding and signaling protein (TRUSS) acts as a positive regulator in variety metabolic disorders. TRUSS expression was increased human specimens with or steatohepatitis, livers high‐fat diet (HFD)‐induced genetically obese mice....
Qushi Huayu Decoction (QHD), an important clinically proved herbal formula, has been reported to be effective in treating fatty liver induced by high-fat diet rats. However, the mechanism of action not clarified at metabolic level. In this study, a urinary metabolomic method based on gas chromatography-mass spectrometry (GC-MS) coupled with pattern recognition analysis was performed three groups (control, model, and QHD group), explore effect its action. There obvious separation between...
Background and Aims: Non-invasive evaluation of liver necroinflammation in patients with chronic disease is an unmet need clinical practice. The diagnostic accuracy transient elastography-based stiffness measurement (LSM) for fibrosis could be affected by necroinflammation, the latter which intensify liver. Such results have prompted us to explore diagnosis potential LSM inflammation. Methods: Three cross-sectional cohorts biopsy-proven were enrolled, including 1417 hepatitis B (CHB) from 10...
Pathological cardiac hypertrophy is a key risk factor for heart failure. We found that the protein expression levels of ZNF307 (zinc finger 307) were significantly increased in samples from both human patients with dilated cardiomyopathy and mice subjected to aortic banding. Therefore, we aimed elucidate role development explore signal transduction events mediate effect on hypertrophy, using cardiac-specific transgenic (ZNF307-TG) global knockout (ZNF307-KO) mice. The results showed deletion...
Asthma is one of the most common childhood chronic diseases worldwide. Subcutaneous immunotherapy (SCIT) commonly used in treatment house dust mite (HDM)‑related asthma children. However, therapeutic mechanism SCIT remains unclear. The present study aimed to investigate molecular biomarkers associated with HDM‑related asthmatic children prior and subsequent compared those healthy via proteomic analysis. included a control group (30 children), ‑Treatment allergic asthma) +Treatment treated...