A5058974765- Forensic Toxicology and Drug Analysis
- Chemical Reaction Mechanisms
- Psychedelics and Drug Studies
- Tuberculosis Research and Epidemiology
- Cancer therapeutics and mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Marine Sponges and Natural Products
- Synthesis and Characterization of Heterocyclic Compounds
- Sulfur-Based Synthesis Techniques
- Computational Drug Discovery Methods
- Chemical synthesis and alkaloids
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cholinesterase and Neurodegenerative Diseases
- Sesquiterpenes and Asteraceae Studies
- Chemical Synthesis and Analysis
- Drug Transport and Resistance Mechanisms
- Seaweed-derived Bioactive Compounds
- Nicotinic Acetylcholine Receptors Study
- Plant Toxicity and Pharmacological Properties
- Traditional and Medicinal Uses of Annonaceae
- DNA and Nucleic Acid Chemistry
- Microbial Natural Products and Biosynthesis
- Forensic and Genetic Research
- Phytochemical Studies and Bioactivities
University of Lisbon
2014-2024
Rede de Química e Tecnologia
2021-2022
Escola Superior de Enfermagem Dr. José Timóteo Montalvão Machado
2017
National Institute of Engineering, Technology and Innovation
2001-2008
Istituto di Chimica Biomolecolare
2008
Lusíada University of Lisbon
2007
Hydrophobicity values (log Po/w) determined both by potentiometry and the conventional shake-flask method aqueous pKa obtained for seven isoniazid nine benzimidazole derivatives are presented. Several of these compounds have strong hydrophilic or hydrophobic character, some them show two more ionizable sites, sometimes very acidic basic. These facts compelled us to work near limits potentiometric technique, therefore, a critical evaluation results in extreme working conditions is...
Because of the complex cascade molecular events that can occur in brain an Alzheimer's disease (AD) patient, therapy this neurodegenerative seems more likely to be achieved by multifunctional drugs. Herein, a new series dual-targeting ligands have been developed and vitro bioevaluated. Their architecture is based on conjugating acetylcholinesterase inhibition anti-oxidant properties one entity. Specifically, naturally occurring phenolic acids with recognized (derivatives caffeic acid,...
Isoniazid (INH) is one of the two most effective first-line antitubercular drugs and still used at present time as a scaffold for developing new compounds to fight TB. In previous study, we have observed that an INH derivative, hydrazide N'-substituted with C10acyl chain, was able counterbalance its smaller reactivity higher membrane permeability. This resulted in improved performance against prevalent Mycobacterium tuberculosis (Mtb) resistant strain (S315T), compared INH. this work,...
A exodontia de terceiros molares frequentemente resulta em lesões nervosas, como a parestesia, que pode afetar qualidade vida do paciente. Embora existam tratamentos, prevenção é essencial. laserterapia, especialmente com Laser Baixa Potência, tem se mostrado promissora na recuperação das fibras nervosas e modulação da dor. Diante exposto, o presente estudo objetivo realizar uma revisão narrativa literatura acerca contribuições laserterapia no manejo terapêutico parestesia após molares. O...
Abstract The emergence of potentially dangerous new psychoactive substances (NPS) is challenging for forensic laboratories, as well the ability to develop and validate methods a rapid unambiguous monitoring these compounds. Thereupon, aim this work was establish methodology identification quantification four synthetic cathinones already seized in Portugal [4-chloroethcathinone (4-CEC), α-pyrrolidinovalerophenone (α-PVP), 4-chloro-pyrrolidinovalerophenone (4-Cl-PVP) methylenedioxypyrovalerone...
This paper reports the chemical study of a sample Fasciospongia sp. collected along Atlantic Portuguese coast. Three new isomeric furanosesquiterpenes, isomicrocionin-3 (1), (−)-microcionin-1 (2), and (−)-isomicrocionin-1 (3), were isolated with known (−)-ent-pallescensin A (4) (−)-pallescensin-1 (5) from ethyl acetate-soluble portion methanolic extract. The structures compounds elucidated by extensive spectroscopic studies. (−)-Microcionin-1 (2) tested positive against several Gram-negative...
The upsurge of multidrug-resistant tuberculosis has toughened the challenge to put an end this epidemic by 2030. In 2020 number deaths attributed increased as compared 2019 and newly identified cases have been stably close 3%. Such a context stimulated search for new more efficient antitubercular compounds, which culminated in QSAR-oriented design synthesis series isoniazid derivatives active against Mycobacterium . From these, some prospective isonicotinoyl hydrazones hydrazides are studied...
Abstract Several sulfenamide derivatives were designed as possible acetylcholinesterase (AChE) inhibitors. New sulfenamides synthesized and proved to be stable under the physiological conditions used in enzymatic assays. N ‐benzyl‐2‐benzoxazolylsulfenamide (8) ‐benzyl‐2‐benzimidazolylsulfenamide (9) revealed anti‐AChE activity with IC 50 values of 0.6 0.8 μ M , respectively, same magnitude those reported for galantamine tacrine. The affinity biological site was evaluated terms...
Among marine organisms, sponges are the richest sources of pharmacologically-active compounds. Stemming from a previous lead discovery program that gathered comprehensive library organic extracts off-shore region Portugal, crude Erylus cf. deficiens collected in Gorringe Bank (Atlantic Ocean) were tested innovative high throughput screening (HTS) assay for inhibitors indoleamine 2,3-dioxygenase (IDO) and showed activity. Bioassay guided fractionation dichloromethane extract led to isolation...
Abstract Three aryl N ‐pyridylthionocarbamates were synthesized by thioacylation of 2‐aminopyridine and 2‐methylaminopyridine with the respective chlorothionoformates. Their hydrolysis mechanism was studied in aqueous basic media. The ‐(2‐pyridyl)thionocarbamates are considerably less reactive than their oxo analogues, ‐(2‐pyridyl) carbamates, especially ‐monosubstituted ones ( 1a ‐ b ). Absence significant buffer catalysis, isolation product resulting from trapping unsaturated intermediate...
Synthesis of new 2-aminobenzimidazole-1-carbamates was accomplished by carbamoylation 2-aminobenzimidazole using different substituted phenyl chloroformates. The aqueous hydrolysis the compounds examined in pH range 1-13 at 25 ºC. evaluated kinetic parameters led to conclusion that up 4 reaction proceeds a bimolecular attack water N-protonated substrate. This is first time this behavior described for carbamates, and can be ascribed higher basicity benzimidazolyl moiety when compared with...
New secondary aryl N-pyridylcarbamates were prepared by reaction of the aminopyridine anion with chloroformates and their hydrolysis was studied over pH range from 12 to 13.7. The pH–rate profile points an E1cB mechanism, involving pre-equilibrium deprotonation nitrogen atom form that undergoes rate-limiting decomposition into pyridyl isocyanate a phenoxide ion. Further highly reactive water affords N-pyridylcarbamic acid, which spontaneously decomposes carbon dioxide. absence significant...