A5005684789- Forensic Toxicology and Drug Analysis
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Psychedelics and Drug Studies
- Cannabis and Cannabinoid Research
- Cancer-related cognitive impairment studies
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Cancer Treatment and Pharmacology
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Polyamine Metabolism and Applications
- Pesticide Exposure and Toxicity
- Biochemical effects in animals
- Nicotinic Acetylcholine Receptors Study
- Synthesis of Organic Compounds
- Attention Deficit Hyperactivity Disorder
- Synthesis and Biological Evaluation
- Consumer Attitudes and Food Labeling
- Morinda citrifolia extract uses
- Paraquat toxicity studies and treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Protein Tyrosine Phosphatases
- Vehicle emissions and performance
Fernando Pessoa University
2015-2025
Universidade do Porto
2016-2025
Rede de Química e Tecnologia
2015-2024
In-Q-Tel
2015
Humboldt-Universität zu Berlin
2006
Charité - Universitätsmedizin Berlin
2006
3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a widely abused, psychoactive recreational drug. There growing evidence that the MDMA neurotoxic profile may be highly dependent on both its hepatic metabolism and body temperature. Metabolism of involves <i>N</i>-demethylation to 3,4-methylenedioxyamphetamine (MDA), which also drug abuse. MDA are <i>O</i>-demethylenated <i>N-</i>methyl-α-methyldopamine (<i>N</i>-Me-α-MeDA) α-methyldopamine (α-MeDA), respectively, catechols can undergo...
BACKGROUND AND PURPOSE 3,4‐Methylenedioxymethamphetamine (MDMA or ‘Ecstasy’) is a worldwide major drug of abuse known to elicit neurotoxic effects. The mechanisms underlying the effects MDMA are not clear at present, but metabolism dopamine and 5‐HT by monoamine oxidase (MAO), as well hepatic biotransformation into pro‐oxidant reactive metabolites thought contribute its adverse EXPERIMENTAL APPROACH Using mouse brain synaptosomes, we evaluated metabolites, α‐methyldopamine (α‐MeDA),...
The nervous system has a highly complex organization, including many cell types with multiple functions, an intricate anatomy and unique structural functional characteristics; the study of its (dys)functionality following exposure to xenobiotics, neurotoxicology, constitutes important issue in neurosciences.
Paraquat (PQ), a cationic nonselective bipyridyl herbicide, has been used as neurotoxicant to modulate Parkinson's disease in laboratory settings. Other compounds like rotenone (ROT), pesticide, and 1-methyl-4-phenylpyridinium ion (MPP(+)) have widely neurotoxicants. We compared the toxicity of these three neurotoxicants using differentiated dopaminergic SH-SY5Y human cells, aiming elucidate their differential effects. PQ-induced neurotoxicity was shown be concentration time dependent, being...
Abstract Melatonin straddles the boundary between food supplements and medicine. In Portugal, its classification is contingent upon a critical dosage threshold of 2 mg. This study aimed to detail composition melatonin-containing supplements, available in Portugal based on their labels, report number potential intoxications. Data was collected from 44 difference active ingredients revealed towards 16 approved medicines. melatonin intoxication cases 2018 2022 were obtained Portuguese Poisons...
3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a potentially neurotoxic recreational drug of abuse. Though the mechanisms involved are still not completely understood, formation reactive metabolites and mitochondrial dysfunction contribute to MDMA-related neurotoxicity. Neuronal trafficking, their targeting synapses, essential for proper neuronal function survival, rendering neurons particularly vulnerable dysfunction. Indeed, MDMA-associated disruption Ca(2+) homeostasis ATP...
3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a widely abused, psychoactive recreational drug. There are growing evidences that the MDMA neurotoxic profile may be highly dependent on its hepatic metabolism. metabolism leads to production of reactive derivates, namely catechols, catechol thioethers, and quinones. In this study electrochemical oxidation-reduction processes human metabolites, obtained by chemical synthesis, were evaluated cyclic voltammetry based an cell with glassy...
Doxorubicin (DOX) is an anthracycline used to treat a wide range of tumours. Despite its effectiveness, it associated with long adverse effects, which cognitive deficits stand out. The present study aimed assess the neurologic outcome pathways two clinically relevant cumulative doses DOX. Adult male CD-1 mice received biweekly intraperitoneal administrations for 3 weeks until reaching 9 mg/kg (DOX9) or 18 (DOX18). Animals were euthanized one week after last administration, and biomarkers...