A5068945585- Nerve injury and regeneration
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Hereditary Neurological Disorders
- Peripheral Neuropathies and Disorders
- Cancer Treatment and Pharmacology
- Plant-based Medicinal Research
- Myasthenia Gravis and Thymoma
- Pain Mechanisms and Treatments
- Abdominal Surgery and Complications
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Congenital Diaphragmatic Hernia Studies
- Advanced Sensor and Energy Harvesting Materials
- Spectroscopy Techniques in Biomedical and Chemical Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Wound Healing and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Hernia repair and management
- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- Pneumothorax, Barotrauma, Emphysema
- Nuclear Structure and Function
- Bone Tissue Engineering Materials
- Chemotherapy-related skin toxicity
RWTH Aachen University
2019-2025
Universitätsklinikum Aachen
2019-2025
Polypropylene (PP) mesh is widely used to reinforce tissues. The foreign body reaction (FBR) the implant dominated by innate immune cells, especially macrophages. However, considerable numbers of adaptive namely T have also been regularly observed, which appear play a crucial role in long-term host response.This study investigated FBR seven human PP meshes, were removed from abdomen for recurrence after median one year. Using immunofluorescence microscopy, was examined various (CD11b+...
Biallelic loss-of-function mutations in the sorbitol dehydrogenase (SORD) gene cause most common recessive type of Charcot-Marie-Tooth disease (CMT), CMT-SORD. However, full genotype-phenotype spectrum and progression remain to be defined. Notably, a multicenter phase 2/3 study test efficacy govorestat (NCT05397665), new aldose reductase inhibitor, is currently ongoing. Diagnosing CMT-SORD will become imperative when disease-modifying therapies available. In this cross-sectional multicentre...
Severe traumatic spinal cord injury (SCI) results in a devastating and permanent loss of function, is currently an incurable condition. It generally accepted that future intervention strategies will require combinational approaches, including bioengineered scaffolds, to support axon growth across tissue scarring cystic cavitation. Previously, we demonstrated implantation microporous type-I collagen scaffold into experimental model SCI was capable supporting functional recovery the absence...
In this study, well-defined, 3D arrays of air-suspended melt electrowritten fibers are made from medical grade poly(ɛ-caprolactone) (PCL). Low processing temperatures, lower voltages, ambient temperature, increased collector distance, and high speeds all aid to direct-write suspended that can span gaps several millimeters between support structures. Such parameters quantitatively determined using a "wedge-design" test frame identify the conditions increase suspension probability...
Schwann cell (SC) transplantation represents a promising therapeutic approach for traumatic spinal cord injury but is frustrated by barrier formation, preventing migration, and axonal regeneration at the interface between grafted SCs reactive resident astrocytes (ACs). Although regenerating axons successfully extend into SC grafts, only few cross SC-AC to re-enter lesioned neuropil. To date, research has focused on identifying modifying molecular mechanisms underlying such scarring cell-cell...
Abstract Background Mesh implants are widely used to reinforce the abdominal wall, although inevitable inflammatory foreign body reaction (FBR) at interface leads complications. Macrophages suspected regulate subsequent scar formation, but it is still unclear whether adequate fibrous formation with collagen deposition depends mainly on presence of M1 or M2 macrophages. Methods This study investigated FBR seven human polypropylene meshes, which were removed after a median incorporation time 1...
Severe spinal cord injury (SCI) results in permanent functional deficits, which despite pre-clinical advances, remain untreatable. Combinational approaches, including the implantation of bioengineered scaffolds are likely to promote significant tissue repair. However, this critically depends on extent host can integrate with implant. In present paper, blood vessel formation and maturation were studied within around implanted micro-structured type-I collagen at 10 weeks post adult rat...
Liver cancer is one of the most frequently diagnosed and fatal cancers worldwide, with hepatocellular carcinoma (HCC) being common primary liver cancer. Hundreds studies involving thousands patients have now been analysed across different types, including HCC, regarding effects immune infiltrates on prognosis patients. However, for these analyses, an unambiguous delineation area paramount, which difficult due to strong heterogeneity considerable inter-operator variability induced by...
Numerous intervention strategies have been developed to promote functional tissue repair following experimental spinal cord injury (SCI), including the bridging of lesion-induced cystic cavities with bioengineered scaffolds. Integration between such implanted scaffolds and lesioned host is critical for supporting regenerative growth, but only moderate-to-low degrees success reported. Light electron microscopy were employed better characterise fibroadhesive scarring process taking place after...
Traumatic injuries to the central nervous system (CNS) result in disruption of intricate network axons which connect functionally related neurons that are widely distributed throughout brain and spinal cord. Under normal conditions, maintenance this complex is structurally supported by astrocytes (ACs) other glial cells, processes form a framework surrounding neuronal cell bodies, dendrites, axons, synapses. Following injury, however, ACs adopt reactive, scar-forming phenotype establish...
<title>Abstract</title> Background Chronic immune-mediated neuropathies are clinically heterogeneous and require regular, objective, multidimensional monitoring to individualize treatment. However, established outcome measures insufficient regarding measurement quality criteria or functional relevance. Wearables such as data gloves might be helpful, allowing repeated quantification of complex everyday life-relevant motor function the hand. This proof-of-concept study therefore aimed evaluate...
Abstract Background Chronic immune-mediated neuropathies are clinically heterogeneous and require regular, objective, multidimensional monitoring to individualize treatment. However, established outcome measures insufficient regarding measurement quality criteria (e.g., reliability, objectivity) or functional relevance. Wearables such as data gloves might be helpful, allowing repeated quantification of complex everyday life-relevant motor function the hand. Methods 25 patients with chronic...
Zahlreiche in der klinischen Routine eingesetzte Wirkstoffe jenseits von Chemotherapeutika und Antiinfektiva können eine Polyneuropathie verstärken oder hervorrufen. Kenntnis darüber, welche Medikamente mit Polyneuropathien assoziiert sind sowie über Risikofaktoren seitens Patienten die Häufigkeit reduzieren. Bei entsprechendem Risiko sollten alternative Präparate eingesetzt Indikation zur Therapie generell überdacht werden.
Zusammenfassung Zahlreiche Wirkstoffe können mit dem erstmaligen Auftreten oder Fortschreiten neuropathischer Symptome in Verbindung gebracht werden. Insbesondere im Kontext der modernen Polypharmazie kommt medikamentös-induzierten Polyneuropathien eine besondere Bedeutung zu. Die Schädigungsmechanismen und individuellen Risikofaktoren sind vielfältig. In den meisten Fällen resultiert längenabhängige, axonale Polyneuropathie vorwiegend sensiblen Symptomen. Grundlegende Kenntnisse darüber,...
Polyneuropathien können durch zahlreiche Wirkstoffe hervorgerufen oder aggraviert werden. Insbesondere die Chemotherapeutika-induzierte Polyneuropathie (CIPN) ist im Alltag von hoher Relevanz. Jedoch kann auch der Einsatz Antiinfektiva zu neuropathischen Beschwerden führen. Im Folgenden soll ein Überblick über wichtigsten mit assoziierten Substanzklassen sowie klinischen Charakteristika gegeben
Abstract Aim Polypropylene (PP) mesh is widely used to reinforce tissues. The foreign body reaction (FBR) the implant dominated by innate immune cells, especially macrophages. However, considerable numbers of adaptive cells have also been regularly observed, which appear play a crucial role in long-term host response. This study investigated FBR seven human PP meshes, were removed from abdomen for recurrence after median one year. Material and Methods Using immunofluorescence microscopy...