A5058694937- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Aquaculture Nutrition and Growth
- Alzheimer's disease research and treatments
- Biofuel production and bioconversion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Aquaculture disease management and microbiota
- Fungal Plant Pathogen Control
- Fish Biology and Ecology Studies
- Trace Elements in Health
- Multiple Myeloma Research and Treatments
- Microbial Metabolic Engineering and Bioproduction
- Moringa oleifera research and applications
- Aquatic life and conservation
- Acute Lymphoblastic Leukemia research
- Drug Transport and Resistance Mechanisms
- Cancer Genomics and Diagnostics
- Pomegranate: compositions and health benefits
- Cholesterol and Lipid Metabolism
- Phytase and its Applications
- Ginkgo biloba and Cashew Applications
- Protein Degradation and Inhibitors
- Catalysis for Biomass Conversion
- Kruppel-like factors research
University of Education
2018-2023
University of Okara
2020-2023
University of Lahore
2016-2021
University of the Punjab
2014-2019
University of Sargodha
2015
Icahn School of Medicine at Mount Sinai
2007-2011
The Alzheimer disease (AD) amyloid protein precursor (APP) can bind the FE65 adaptor and this complex regulate gene expression. We carried out yeast two-hybrid studies with a PTB domain of FE65, focusing on those genes that might be involved in nuclear signaling, identified validated Teashirt proteins as interacting neurons. Using reporter systems, we observed could simultaneously recruit SET, component inhibitor acetyl transferase, Teashirt, which turn recruited histone deacetylases, to...
Cholesterol content of cerebral membranes is tightly regulated by elaborate mechanisms that balance the level cholesterol synthesis, uptake and efflux. Among conventional regulatory elements, a recent research focus has been nuclear receptors, superfamily ligand-activated transcription factors providing an indispensable framework in controlling metabolism pathway genes. The mechanism transcriptional regulation receptors such as LXRs involves formation heterodimers with RXRs. LXR/RXR...
Background and objectives: Chromosomal abnormalities play an important role in genesis of acute lymphoblastic leukemia (ALL) have prognostic implications. Five major risk stratifying fusion genes ALL are BCR-ABL, MLL-AF4, ETV6-RUNX11, E2A-PBX1 SIL-TAL1. This work aimed to detect common chromosomal translocations associated oncogenes adult patients study their relationship with clinical features treatment outcome. Methods: We studied 104 using RT-PCR interphase-FISH at diagnosis association...
Rat sarcoma gene (RAS) holds great importance in pathogenesis of acute myeloid leukemia (AML). The activated mutations Neuroblastoma rat viral oncogene homolog (NRAS) and Kirsten (KRAS) confers proliferative survival signals, deliberating numerous effects on overall progression free AML patients. In this study thirty one (31) blood samples adult newly diagnosed patients were collected to identify possible incidence through amplification KRAS (exon 1 2) NRAS using polymerase chain reaction...
BCR-ABL kinase domain (KD) mutations are well known for causing resistance against tyrosine inhibitors (TKIs) and disease progression in chronic myeloid leukemia (CML). In recent years, compound have emerged as a new threat to CML patients by higher degrees of involving multiple TKIs, including ponatinib. However, there limited reports about association with imatinib (IM) sensitive patients. Therefore, we investigated presence ABL-KD phase (n = 41), late 33) accelerated 16) responders....
Pomegranate peels (PPW) as municipal waste is inexpensive biomass that could be a renewable source of sugars particularly rich in hemicellulosic contents. The subsequent conversion available PPW can provide prospective strategy for cost-effective bioenergy production. In this study, an experimental setup based on CCD was implemented with the aim bioconversion into bioethanol. factors considered were Hydrochloric acid concentration (X1), hydrolysis temperature (X2) and time (X3) optimization...
Acute myeloid leukemia (AML) is a bone marrow malignancy having multiple molecular pathways driving its progress. In recent years, the main causes of AML considered all over world are genetic variations in cancerous cells. The RUNX1 and FLT3 genes necessary for normal hematopoiesis differentiation process hematopoietic stem cells into mature blood cells, therefore they most common targets point mutations resulting AML.We screened 32 CN-AML patients FLT3-ITD (by Allele-specific PCR) Sanger...
The study investigated the potential of probiotic isolate Bacillus subtilis AsCh-A4 (Accession No. MF543124) fermented feed to improve growth profile Labeo rohita fingerlings. Morphometric measurements and nutritional indices control experimental groups were compared fortnightly in 90 days experiment. formulated fish was by up seven administered at 3% (b/w) with live (G1) dead (G2) bacterium. G1 group showed significant higher values DG (Daily gain) RGR% (percent relative rate) wet body...
Different types of abiotic stresses inhibit the normal growth plants by changing their physical biochemical, morphological, and molecular traits. It links to polygenic traits, which is controlled with help different genes, due this polygenetic manipulation foreign genetic makeup very difficult. Drought stress major type threat reduce yield cash crops in Pakistan as well all over world. Gene solution face problem producing genetically modified crop that have ability survive drought...
A 70-days feeding trial was conducted to assess the impact of polyphenols supplemented canola meal based diets on growth performance, nutrient digestibility and antioxidant activity common carp (Cyprinus carpio Linnaeus, 1758) fingerlings. Seven experimental viz., T0, T1, T2, T3, T4, T5, T6 T7 with graded levels at 0, 100, 200, 300, 400, 500 600 mg kg-1 respectively were formulated. Each treatment diet fed fishes in triplicate tanks each replicate, fifteen fingerlings stocked. Effect weight...
Sunflower meal based diet supplemented with selenium nanoparticles (Se NPs) atlevels of 0, 1, 2, 3, 4 and 5 mg kg-1 were fed common carp (Cyprinus carpio Linnaeus 1758) fingerlings in a seventy days feeding trial, to examine the effects on growth, nutrient digestibility heamatology. Triplicate tanks used each tank contained 15 that subjected experimental at 4% their live wet weight. A non-digestible marker, chromic oxide was added feed 1% level. Growth performance terms weight gain %,...
This study was attempted to investigate the probiotic effect of a novel locally isolated bacterium from home-made yogurt, Sphingomonas sp.AsCh-P3 on growth, survival and biochemical constituents Labeo rohita fingerlings challenged with well-renowned fish pathogenic Vibrio anguillarum.Positive control-C2 as well experimental groups V. anguillarum intraperitoneally.Probiotic treated feed antibacterial potential against administered fishes in different groups; G1 (soon after challenge for 30...
In this study, effects of dietary supplementation two different hormones on growth, sex conversion and reproduction electric yellow cichlid, Labidochromis caeruleus were investigated.Moreover, possible negative (sterilization, mortality, performance etc.) positive (growth, conversation impacts hormone administration also assessed.This study had experiments.In the first experiment, six experimental feeds prepared by adding (17α-Methyltestosterone (Mt), 17β-Estradiol (Es) at three doses (20,...
Acute myeloid leukemia (AML) is a blood cancer and malignant disorder of the bone marrow in which hematopoietic precursors are ceased at an early stage development, preventing them from differentiating. The NRAS gene plays vital role regulating cell division. mutation this leads to increased activity RAS pathway, proliferation decreased apoptosis rates causes AML. Objective: To identify deleterious SNPs involved AML further analyze using bioinformatics tools. Methods: missense nsSNPs (Q61H,...
The most frequently reported genetic aberration among polycythemia vera (PV) patients is a gain of function mutation V617F in exon 14 Janus kinase 2 (JAK2) gene.However many investigations, negative PV have been to harbor mutations JAK 12.We investigated 24 with (diagnosed following 2016 WHO guidelines) detect through allele specific PCR.The frequency which was found be 19/24 (79.2 %).Later on JAK2 12 and amplified by conventional PCR subjected sequence analysis.A total 03 mutated sites were...
Objective: BCR-ABL fusion oncogene is the hallmark of chronic myeloid leukemia (CML), causing genomic instability which leads to accumulation mutations in as well other genes. are cause tyrosine kinase inhibitors (TKIs) resistance CML. Recently, compound have been reported resist all FDA approved TKIs. Therefore, finding novel can help and clinically manage our objective was find out drug-resistant CML carry their protein modelling studies. Methodology: Peripheral blood samples were...