A5074056460- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Blood properties and coagulation
- Blood Coagulation and Thrombosis Mechanisms
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- interferon and immune responses
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
- Nanoparticles: synthesis and applications
University of Brescia
2021-2024
Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase
2022-2023
Helmholtz Zentrum München
2022
To be profitably exploited in medicine, nanosized systems must endowed with biocompatibility, targeting capability, the ability to evade immune system, and resistance clearance. Currently, biogenic nanoparticles, such as extracellular vesicles (EVs), are intensively investigated platform that naturally recapitulates these highly needed characteristics. EV native properties pharmacokinetics can further augmented by decorating surface specific target ligands antibodies. However, date, studies...
Abstract Antithrombin (AT) is a glycoprotein produced by the liver and principal antagonist of active clotting proteases. A deficit in AT function leads to qualitative deficiency, challenging diagnose. Here we report that may travel physiosorbed on surface plasma extracellular vesicles (EVs), contributing form “EV‐protein corona.” The corona enriched specific glycoforms, thus suggesting glycosylation play key role partitioning between EVs plasma. Differences glycoform composition separated...
Triple-negative breast cancer is an aggressive subtype characterized by the absence of human epidermal growth factor receptor 2, estrogen and progesterone receptors, limiting targeted therapy options. Cisplatin, a chemotherapeutic agent, induces DNA damage exhibits some efficacy against triple-negative cancer, but its effectiveness often reduced chemoresistance systemic toxicity. A very promising strategy to augment cisplatin treatment can be based on combining it with biologic Cetuximab,...
Superparamagnetic iron oxide nanoparticles (SPIONs) have gained increasing interest in nanomedicine, but most of those that entered the clinical trials been withdrawn due to toxicity concerns. Therefore, there is an urgent need design low-risk and biocompatible SPION formulations. In this work, we present original safe-by-design nanoplatform made silica loaded with SPIONs decorated polydopamine (SPIONs@SiO2-PDA) study its biocompatibility performance by ad hoc thorough vitro vivo...
Abstract Antithrombin (AT) is a glycoprotein produced by the liver and principal antagonist of active clotting proteases. A deficit in AT function leads to qualitative deficiency, challenging diagnose. Here we report that may travel physiosorbed on surface plasma extracellular vesicles (EVs), contributing form “EV-protein corona”. The corona enriched specific glycoforms, thus suggesting glycosylation play key role partitioning between EVs plasma. Differences glycoform composition separated...
To be profitably exploited in medicine as drug delivery carriers, nanosized systems should endowed with essential properties, including high biocompatibility, stealth ability to escape the immune system, prolonged circulation lifetime, and targeting abilities towards pathological tissues. Currently, choice of biogenic nanoparticles Extracellular Vesicles (EVs) represents most promising strategy deal clearance issues. EV properties pharmacokinetics could augmented by surface engineering...
The physiological relevance of cell-to-cell communication mediated by small extracellular vesicle-encapsulated microRNAs (sEV-miRNAs) remains debated because the limiting representativity specific miRNAs within pool. We hypothesize that sEV-miRNA non-canonical function consisting stimulation Toll-like receptor 7 (TLR7) may rely on a global shift sEV cargo rather than induction one or few miRNAs. Psoriasis represents an ideal model to test such hypothesis as it is driven overt activation...
To be profitably exploited in medicine, nanosized systems must endowed with biocompatibility, targeting capability, the ability to evade immune system, and resistance clearance. Currently, biogenic nanoparticles, such as Extracellular Vesicles (EVs), are intensively investigated platform that naturally recapitulates these highly needed characteristics. EV native properties pharmacokinetics can further augmented by decorating surface specific target ligands antibodies. However, up date, works...
To be profitably exploited in medicine, nanosized systems must endowed with biocompatibility, targeting capability, the ability to evade immune system, and resistance clearance. Currently, biogenic nanoparticles, such as Extracellular Vesicles (EVs), are intensively investigated platform that naturally recapitulates these highly needed characteristics. EV native properties pharmacokinetics can further augmented by decorating surface specific target ligands antibodies. However, up date, works...