The hairless, thickened glabrous skin of the palms and soles differs significantly from rest body, presenting unique challenges to surgeons treating wounds in these areas, such as burns. Traditionally, full-thickness, non-glabrous grafts have been used for repairs, often leading complications hyperkeratosis epidermolysis. These can also be cosmetically displeasing, resulting unwanted hair growth hyperpigmentation, particularly individuals with darker skin. Multiple grafting techniques...

Despite advancements in surgical and rehabilitation strategies, extremity amputations are frequently associated with disability, phantom limb sensations, chronic pain. Investigation into potential treatment modalities has focused on the pathophysiological changes both peripheral central nervous systems to better understand underlying mechanism development of pain persons amputations.Presented this article is a discussion outlining physiological that occur following amputation. In review,...

Background: Random pattern skin flaps are applicable for reconstructing any defect in plastic surgery. However, they difficult to apply because of necrosis. Sumatriptan, a selective 5-hydroxytryptamine 1b/1d agonist, is routinely used offset acute migraine attacks. Recent studies have suggested that sumatriptan may induce vasodilation at lower concentrations. The authors’ aim investigate the effect on flap survival and role nitric oxide this phenomenon. Methods: Seventy-two male...

Radiation-induced peripheral neuropathy is a rare, but serious complication often resulting in profound morbidity, life-long disability, and chronic debilitating pain. Unfortunately, this type of usually progressive, almost always irreversible. To date, standardized rat model radiation-induced has not been established. The purpose the present study was to examine neuropathic pain, sensorimotor impairment, muscle force parameters following administration clinically relevant radiation dose model.

To investigate the therapeutic effects of sumatriptan in a rat model spinal cord injury (SCI) and possible anti-inflammatory analgesic mechanisms underlying this effect.Using an aneurysm mini-clip contusive SCI, T9-10 laminectomies were performed for 60 male rats. Animals divided into six experimental groups (n = 10 per group) as follows: minocycline administered positive control group, saline-vehicle negative sham-operated three which received separate doses (0.1, 0.3 1 mg/kg). Behavioural...

Background. Robotic exoskeleton devices have become a promising modality for restoration of extremity function in individuals with limb loss or functional weakness. However, there exists no consistent reliable way to record efferent motor action potentials from intact peripheral nerves control device movement. Peripheral nerve are similar amplitude that background noise, producing an unfavorable signal-to-noise ratio (SNR) makes these signals difficult detect and interpret. To address this...

BACKGROUND: Treating neuroma pain is a clinical challenge. Identification of sex-specific nociceptive pathways allows more individualized management. The Regenerative Peripheral Nerve Interface (RPNI) consists neurotized autologous free muscle using severed peripheral nerve to provide physiological targets for the regenerating axons. OBJECTIVE: To evaluate prophylactic RPNI prevent in male and female rats. METHODS: F344 rats each sex were assigned neuroma, RPNI, or sham groups. Neuromas...

Robotic exoskeletons have gained recent acclaim within the field of rehabilitative medicine as a promising modality for functional restoration those individuals with extremity weakness. However, their use remains largely confined to research institutions, frequently operating means static support motor detection methods remain unreliable. Peripheral nerve interfaces arisen potential solution this shortcoming; however, due inherently small amplitudes, these signals can be difficult...

Background Recent reports have identified angiogenic, anti-inflammatory, and antioxidant properties of acute treatment with nicotine via activation nicotinic acetylcholine receptors (nAChRs). In addition, the nitric oxide (NO) pathway is involved in ischemic reperfusion injuries. Objectives We investigated effects pretreatment a rat model random-pattern skin flap potential role NO pathway. Methods The Sprague-Dawley rats received increasing doses (−)-nicotine (0.5, 1, 1.5, 2, 3 mg/kg) before...

Adams-Oliver syndrome (AOS) is characterized by the combination of congenital scalp defects (aplasia cutis congenita) and terminal transverse limb variable severity. It believed that without major organ abnormalities does not necessarily alter normal lifespan. We present a case detectable abnormality contrary to life but with poor weight gain. A male infant skin aplasia, generalized dilated veins over trunk, hypoplastic toes nails feet, glaucoma, feeding This report shows AOS multiple...

Inadequate tissue perfusion is a serious complication following reconstructive surgeries. Skin flap necrosis, especially in the head and neck area, may have significant cosmetic consequences. Although clinical exam mainstay evaluating perfusion, it not always predict ischemic problems. The SPY Elite laser angiographic system, which has been widely used to analyze postmastectomy skin flaps, shown be able evaluate objectively. We describe revision rhinoplasty case where hypoperfusion of nasal...

OBJECTIVE: Vascularized composite allotranplantation (VCA) is an evolving area to reconstruct tissue defects. One of the challenges in VCA narrow window tolerable ischemia time. Current standard care, static cold storage, only effective for short periods and may result severe damage acute rejection when prolonged. Ex-situ perfusion has potential overcome these by extending allowable However, optimum perfusate composition, preservation temperature, hemodynamic parameters are still debated....

Purpose:Advanced motorized prosthetic limbs are capable of fine multiple joint manipulations and possess the potential to emulate intricate functions native extremity. Equipped with force or pressure sensors, these devices also able provide tactile information user. However, increasing a prosthetic’s manipulative degrees freedom requires additional controlled inputs from amputee. The development reliable interface between amputee device is therefore crucial for closing motor-sensory feedback...

Purpose: Sensory tactile feedback is crucial in our everyday lives as it helps us characterize held objects, modulate motor actions, and understand limb's position space. Though sensors for exteroceptive stimuli detection have been developed advanced prostheses, persons with upper extremity amputation often never regain physiologically relevant, natural sensory largely part due to lack of an appropriate user-prosthetic interface. Current neural interfaces stable long-term transmission...

Purpose: Exoskeletons have become a promising device to restore extremity function those with limb weakness. However, these devices not widely adopted due the inadequacy of current nerve interfacing methods. The Muscle Cuff Regenerative Peripheral Nerve Interface (MC-RPNI) was developed as potential solution this problem. Consisting segment autologous free muscle secured around an intact nerve, MC-RPNI is able regenerate and reinnervate, amplifying its contained nerve’s signals through...

The authors describe a case of retained sterile matrix in 38-year-old Hispanic man with history remote trauma and soft-tissue coverage groin flap 13 years before presentation. patient presented slowly enlarging, vertically growing dorsal thumb mass occasional drainage. had minimal functional impairment, radiographic imaging showed radiolucent projecting dorsally over the distal phalanx. Surgical exploration revealed an approximately 2 × cm keratinized attached to nail bed. plate was removed,...

Robotic exoskeletons have gained recent acclaim within the field of rehabilitative medicine as a promising modality for functional restoration those individuals with extremity weakness. However, their use remains largely confined to research institutions, frequently operating means static support motor detection methods remain unreliable. Peripheral nerve interfaces arisen potential solution this shortcoming; however, due inherently small amplitudes, these signals can be difficult...

Purpose: Advanced exoskeletons have been developed as assistive devices for those individuals with extremity weakness. Unfortunately, they are rarely utilized secondary to inadequate human-machine interfacing capabilities. To address this limitation, we the Muscle Cuff Regenerative Peripheral Nerve Interface (MC-RPNI) which consists of a free skeletal muscle graft wrapped around an intact peripheral nerve. Over time, MC-RPNI regenerates and becomes reinnervated has ability amplify efferent...

Purpose: Approximately 2 million people in the United States suffer from chronic peripheral nerve pain symptomatic neuromas following limb amputation. Development of these triggers a cascade immunological and molecular changes tissue, resulting hypersensitivity markers both central nervous system. Unfortunately, no gold standard care, either surgical or pharmacological, currently exists for treatment neuropathic neuromas. Furthermore, recent evidence suggests that sexual dimorphic mechanisms...

Purpose: Radiation therapy (XRT) is one of the mainstays cancer treatment, with approximately 50% patients requiring XRT as part their treatment regimen. Of these patients, almost 31% subsequently suffer from debilitating neuropathic pain and sensory nerve abnormalities. induced peripheral neuropathy results in progressive, intractable, often irreversible which can have a devastating effect on patients' quality life potentially reduce overall benefit itself. We previously established novel...