A5047678857- Nuclear Structure and Function
- RNA Research and Splicing
- RNA modifications and cancer
- Cellular transport and secretion
- Genetic Associations and Epidemiology
- Microtubule and mitosis dynamics
- Bioinformatics and Genomic Networks
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Monoclonal and Polyclonal Antibodies Research
- Trace Elements in Health
- Retinal Development and Disorders
- Metabolism, Diabetes, and Cancer
- Muscle Physiology and Disorders
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- T-cell and B-cell Immunology
- Biotin and Related Studies
- Adipose Tissue and Metabolism
- Peptidase Inhibition and Analysis
- Nutrition, Genetics, and Disease
Pfizer (United States)
2023-2024
Discovery Institute
2017-2023
Sanford Burnham Prebys Medical Discovery Institute
2017-2023
University of Cambridge
2014
Cardiovascular Institute Hospital
2013
Institute of Molecular Biology and Biophysics
2013
University of California, San Francisco
2013
Cancer Research UK
2008-2009
Circulating proteins can reveal key pathways to cancer and identify therapeutic targets for prevention. We investigate 2,074 circulating risk of nine common cancers (bladder, breast, endometrium, head neck, lung, ovary, pancreas, kidney, malignant non-melanoma) using cis protein Mendelian randomisation colocalization. conduct additional analyses adverse side-effects altering map drug targets. Here we find 40 associated with cancers, such as PLAUR breast [odds ratio per standard deviation...
Article16 May 2014Open Access Source Data Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer Vincent Zecchini Corresponding Author Department of CRUK, CRUK Cambridge Institute, University Cambridge, UK Search for more papers by this author Basetti Madhu Roslin Russell Nelma Pértega-Gomes Life Health Sciences Research School Sciences, Minho, Braga, Portugal Anne Warren Pathology, Edoardo Gaude Medical Council Cancer Cell Unit, Hutchison/MRC Centre,...
Background Clathrin is a multimeric protein involved in vesicle coat assembly. Recently clathrin distribution was reported to change during the cell cycle and found associate with mitotic spindle. Here we test whether recruitment of spindle indicative critical functional contribution mitosis. Methodology/Principal Findings Previously chicken pre-B lymphoma line (DKO-R) developed which endogenous heavy chain alleles were replaced human under control tetracycline-regulatable promoter....
Abstract Background Understanding the role of circulating proteins in cancer risk can reveal key biological pathways and identify novel therapeutic targets for prevention. Methods We investigated associations 2,094 with nine common cancers (bladder, breast, endometrium, head neck, lung, ovary, pancreas, kidney, malignant non-melanoma) using cis pQTL Mendelian randomisation (MR) colocalization. Findings support from both MR, after correction multiple-testing, colocalization were replicated an...
Abstract PF-07062119 (GUCY2C x CD3), a bispecific T cell engager (TCE) targeting Guanylyl Cyclase C (GUCY2C), GI tumor associated antigen, is currently being evaluated in Phase 1 clinical trial colorectal cancer (CRC) and other malignancies. Improved pre-clinical understanding of the correlates resistance mechanisms PD human disease relevant context critical to better inform drug combination patient selection strategy. Due limited translatability mouse syngeneic models, establishing more...
<p>Supplementary Movie</p>
<p>Supplementary Figures and Methods</p>
<div>Abstract<p>Nuclear pore complexes (NPC) are the central mediators of nucleocytoplasmic transport. Increasing evidence shows that many cancer cells have increased numbers NPCs and become addicted to nuclear transport machinery. How reducing NPC affects physiology normal whether it could be exploited for therapies has not been investigated. We report inhibition formation, a process mostly restricted proliferating cells, causes selective cell death, prevents tumor growth,...
<p>Supplementary Figures and Methods</p>
<p>Supplementary Movie</p>
<div>Abstract<p>Nuclear pore complexes (NPC) are the central mediators of nucleocytoplasmic transport. Increasing evidence shows that many cancer cells have increased numbers NPCs and become addicted to nuclear transport machinery. How reducing NPC affects physiology normal whether it could be exploited for therapies has not been investigated. We report inhibition formation, a process mostly restricted proliferating cells, causes selective cell death, prevents tumor growth,...