A5074203426- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Human Health and Disease
- Eosinophilic Disorders and Syndromes
- Hematological disorders and diagnostics
- Healthcare Systems and Public Health
- Biomarkers in Disease Mechanisms
- Neurological Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Dermatological and COVID-19 studies
- Glutathione Transferases and Polymorphisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiomyopathy and Myosin Studies
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Pediatric health and respiratory diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Macrophage Migration Inhibitory Factor
- Hemoglobinopathies and Related Disorders
- Galectins and Cancer Biology
- Alkaline Phosphatase Research Studies
- Cancer Treatment and Pharmacology
- Medicinal Plants and Bioactive Compounds
- Kruppel-like factors research
Bashkir State Medical University
2014-2023
Ministry of Health of the Russian Federation
2014-2023
Republican Clinical Hospital named after G.G. Kuvatova
2017-2022
In an noninterventional observational open multicenter program CHRONOGRAF the prevalence of markers chronic kidney disease (CKD) was studied in 1600 patients with arterial hypertension and without type 2 diabetes mellitus. Glomerular filtration rate (GFR) calculated (CKD-EPI formula) albuminuria (AU) determined as albumin/creatinine (A/ Cr) ratio morning portion urine. 49.4% decreased GFR and/or A/Cr >30 mg/ g detected. Decrease found 34.8% patients, mg/g - 32.6%, combination reduced...
Background. Due to the significant increase in life expectancy and quality of patients with chronic myeloid leukemia (CML) as well growing need for expensive tyrosine kinase inhibitors (TKI), analysis cost-effectiveness lifelong monitoring is especially important. Aim. We present results a multicenter observational study “The Russian Registry Chronic Myeloid Leukemia routine clinical practice (2011-2016)”. Materials & Methods. The included CML, confirmed by detection Ph-chromosome or...
It is known that iron deficiency a negative factor for the onset of pregnancy. aggravates its course, increasing risk preeclampsia, placental insufficiency, uterine inertia, premature birth, bleeding and hypogalactia. This condition increases unfavorable outcomes, anemia cognitive delay in child. Raising awareness women reproductive age clinical suspicion physicians regarding latent can facilitate timely visit doctor. At expert council "Relevant issues Russian Federation" held June 2020,...
The study was to analyze the relationship laboratory parameters of blood in acute phase hemorrhagic stroke and its unfavorable outcomes within 90 days.We performed retrospective analysis 122 patients with from Dyurtyuli district hospital between 2015 2020. favorable were compared. Multivariate identify independent predictors death after stroke.Death days registered 16 cases (13%). In this group count RBC, lymphocytes, prothrombin index, hemoglobin level lower, WBC, neutrophil-lymphocyte...
Background. The national observational program MPN-QoL-2020 was focused on quality of life (QoL) and symptoms in patients with classical Ph-negative myeloproliferative neoplasms (MPNs) the Russian Federation, as well perception disease treatment from patient's physician's perspective. Aim. To evaluate QoL different MPNs using new standardized questionnaires, to assess most common their impact myelofibrosis (MF), polycythemia vera (PV) essential throm-bocythemia (ET), characterize concerns...
Sequence based typing was used to identify human leukocyte antigen (HLA)-A, -B, -C, -DRB1 alleles in 1,064 recruited volunteers the Republic of Bashkortostan Russian Federation for unrelated hematopoietic stem cell registry. During carried out research two new were identified studied population; one registered WHO Nomenclature Committee Factors HLA System, other submitted registration. In this population 17 HLA-A, 29 – HLA-B, 13 HLA-C, HLA-DRB1 groups selected. Allele frequencies more than...
Use of tyrosine kinase inhibitor imatinib has led to significant progress in chronic myeloid leukemia (CML) treatment. To date, genetic monitoring is a mandatory attribute therapy with inhibitors. The purpose this study was access the therapy efficacy CML patients using complete molecular genetic monitoring by standard cytogenetics, realtime polymerase chain reaction and mutational analysis. Correlation between cytogenetic and response shown. Heterogeneity each patient group revealed...
Cardiomyopathies (CMP) are considered diseases with unknown etiology. CMP usually diagnosed on the late stages of disease. It is an important task to seek methods which allow diagnosing early development. Aim – estimate type polymorphic variants angiotensin converting enzyme (ACE), glutathione S-transferase (GSTM1) frequency distribution among sick and healthy individuals living in Republic Bashkortostan, substantiate their role pathogenesis. Material Methods There were 67 put under...
Relevance . In accordance with the guidelines on clinical investigation of clotting factor VIII products European Medicines Agency and pharmacovigilance Eurasian Economic Union, after registration a new drug, it is recommended to study its efficacy safety large population patients in standard medical practice clarify identify data. Materials methods prospective, multicenter, open-label, uncontrolled observational study, domestic recombinant B-domain deleted blood FVIII (FVIII) (moroctocog...
Acute myelomonocytic leukemia is a rare form of leukemia, in which the bone marrow damaged by morphologically immature, tumor cells, subsequently displace normal cellular composition and involve other body systems pathological process. Among all acute myeloid leukemias, 5–30 % form. The peculiarity this extramedullary manifestations – leukemides, appearance most often indicates an unfavorable prognosis. article discusses clinical case with development skin lesions (leukemides) patient.
The aim of research was to evaluate the impact erythrocytoses on processes cardiovascular system's remodelling in patients with dilated and ishaemic cardiomyopathies. 35 (42,2%) cardiomyopathy (DCMP) erythrocytoses, 19 (23,5%) without erythrocytosis, 34 (28,4%) (ICMP) erythrocytosis 50 (60,1%) were included study. It has been established that don't wield major influence heart's haemodynamics, they appear as a consequence main diseases not their reason, which confirms domination congestive...
As is known, the SARS-CoV-2 virus affects almost all human systems, organs and tissues, causing their damage to a greater or lesser extent. Follow-up of COVID-19 patients worldwide.indicates significant changes occurring in hematopoiesis system morphology blood cells. This review devoted analysis literature data on effect indicators system, which important practical work healthcare professionals.
One possible manifestation of multiple myeloma may be extramedullary plasmacytoma, manifested by infiltration plasma cells outside the bone marrow. In debut disease, plasmacytomas are most often diagnosed, in contrast to ones, which rare. According literature, presence plasmacytoma is an unfavorable factor characterized aggressive disease course, absence antitumor response standard therapy, and low overall survival rates. Therefore, pathogenesis, clinic, diagnosis treatment this variant...