Heike Schmidt

ORCID: 0000-0003-2628-4454
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About
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Research Areas
  • Aquaculture disease management and microbiota
  • Myxozoan Parasites in Aquatic Species
  • Parasite Biology and Host Interactions
  • Environmental Toxicology and Ecotoxicology
  • Aquatic Invertebrate Ecology and Behavior
  • Fish Ecology and Management Studies
  • Microbial infections and disease research
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Polyamine Metabolism and Applications
  • Biochemical and Molecular Research
  • Reproductive biology and impacts on aquatic species
  • Aquaculture Nutrition and Growth
  • Enzyme Structure and Function
  • Animal Virus Infections Studies
  • Environmental DNA in Biodiversity Studies
  • African history and culture studies
  • Invertebrate Immune Response Mechanisms
  • Organometallic Complex Synthesis and Catalysis
  • Animal testing and alternatives
  • Microbial Metabolic Engineering and Bioproduction
  • Copper Interconnects and Reliability
  • Viral Infections and Vectors
  • Crustacean biology and ecology
  • Amino Acid Enzymes and Metabolism
  • Fungal and yeast genetics research

University of Bern
2016-2025

Universitätsklinik für Strahlentherapie
2023

University Hospital in Halle
2023

Martin Luther University Halle-Wittenberg
2023

Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
2017

Universitätsklinikum Aachen
2017

Chemnitz University of Technology
2003-2013

Marymount University
2011

Mater Misericordiae University Hospital
2011

St. James's Hospital
2011

Water pollution induces pathological changes in fish. As an indicator of exposure to contaminants, histology represents a useful tool assess the degree pollution, particularly for sub‐lethal and chronic effects. However, standardized method description assessment histological changes, mainly use freshwater fish, is still lacking. In this paper, present authors propose findings which can be applied different organs. The methodology based on two factors: (1) extension change rated with ‘score...

10.1046/j.1365-2761.1999.00134.x article EN Journal of Fish Diseases 1999-01-01

Summary The lincomycin (LM)‐production gene cluster of the overproducing strain Streptomyces iincolnensis 78‐11 was cloned, analysed by hybridization, as well DNA sequencing, and compared with respective genome segments other producers. lmb/lmr is composed 27 open reading frames putative biosynthetic or regulatory functions ( lmb genes) three resistance (lmr) genes, two which, lmrA lmrC , flank cluster. A very similar overall organization seems to be conserved in four LM producers, although...

10.1111/j.1365-2958.1995.tb02338.x article EN Molecular Microbiology 1995-06-01

Summary 1. Proliferative kidney disease (PKD) is a of salmonid fish caused by the endoparasitic myxozoan, Tetracapsuloides bryosalmonae , which uses freshwater bryozoans as primary hosts. Clinical PKD characterised temperature‐dependent proliferative and inflammatory response to parasite stages in kidney. 2. Evidence that an emerging includes outbreaks new regions, declines Swiss brown trout populations adoption expensive practices farms reduce heavy losses. Disease‐related mortality wild...

10.1111/j.1365-2427.2010.02465.x article EN Freshwater Biology 2010-07-07

Abstract This study presents an overview of the distribution proliferative kidney disease (PKD) in wild and farmed fish Switzerland based on two sources: (1) results routine diagnostic work at National Fish Disease Laboratory, (2) a country‐wide survey for PKD. The first case PKD was diagnosed 1979 since 1981, few cases have been found every year. Affected species were rainbow trout, brown trout grayling from rivers farms. Most diseased lower altitude regions country (Swiss midlands). A...

10.1046/j.1365-2761.2002.00401.x article EN Journal of Fish Diseases 2002-08-01

Classic (complete) lecithin:cholesterol acyltransferase (LCAT) deficiency and Fish-eye disease (partial LCAT deficiency) are genetic syndromes associated with markedly decreased plasma levels of high density lipoprotein (HDL) cholesterol but not an increased risk atherosclerotic cardiovascular disease. We investigated the metabolism HDL apolipoproteins (apo) apoA-I apoA-II in a total five patients deficiency, one classic four Plasma were to proportionately greater extent (23% normal) than...

10.1172/jci116962 article EN Journal of Clinical Investigation 1994-01-01

Significance Predicting how temperature, climate change, and emerging infectious diseases interact to drive local extinction risk for natural populations requires complex integrated approaches involving field data [fish environmental DNA (eDNA) sampling hydrological geomorphological surveys], laboratory studies (eDNA analyses disease prevalence assessment), metacommunity modeling. Together, these tools reproduce all of the relevant biological ecohydrological features proliferative kidney...

10.1073/pnas.1713691114 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2017-10-23

DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsSpecials 83:67-76 (2009) - DOI: https://doi.org/10.3354/dao01989 Proliferative kidney disease in rainbow trout: time- and temperature-related renal pathology parasite distribution Kathrin Bettge, Thomas Wahli, Helmut Segner, Heike Schmidt-Posthaus* Centre for Fish Wildlife Health, Institute Animal Pathology, University Berne,...

10.3354/dao01989 article EN Diseases of Aquatic Organisms 2008-10-13

SUMMARY Proliferative kidney disease (PKD) of salmonids, caused by Tetracapsuloides bryosalmonae , can lead to high mortalities at elevated water temperature. We evaluated the hypothesis that this mortality is increasing parasite intensity. T. -infected rainbow trout ( Oncorhynchus mykiss ) were reared different temperatures and changes in concentrations compared cumulative mortalities. Results quantification a newly developed real-time PCR agreed with number parasites detected...

10.1017/s0031182009005800 article EN Parasitology 2009-04-14

Seventy-two lynx, found dead in the Swiss Alps and Jura Mountains (Switzerland) from 1987-99, were evaluated to determine cause of death. per cent (52/72) all animals died because noninfectious diseases or causes such as vehicular collision poaching. Eighteen percent (13/72) infectious diseases, including some which could have been transferred lynx domestic other wild panleukopenia sarcoptic mange. If only radio-tagged (included a monitoring program) taken into consideration, percentage...

10.7589/0090-3558-38.1.84 article EN Journal of Wildlife Diseases 2002-01-01

Proliferative kidney disease (PKD) is an endoparasitic of salmonids caused by the myxozoan parasite Tetracapsuloides bryosalmonae. We recently described development from initial infection until manifestation clinical signs in rainbow trout held at 2 water temperatures, 12 and 18°C. The aim present study to investigate whether (1) infected fish surviving phase would recover renal pathological changes, (2) they be able reduce load kidneys, (3) temperatures influence recovery clearance. At...

10.3354/dao02417 article EN Diseases of Aquatic Organisms 2011-11-01

Chlamydia are obligate intracellular bacteria and important pathogens of humans animals. Chlamydia-related also major fish pathogens, infecting epithelial cells the gills skin to cause disease epitheliocystis. Given wide distribution, ancient origins spectacular diversity bony fishes, this group offers a rich resource for identification isolation novel Chlamydia. The broad-nosed pipefish (Syngnathus typhle) is widely distributed genetically diverse temperate species, susceptible...

10.1371/journal.pone.0070853 article EN cc-by PLoS ONE 2013-08-12

A novel picornavirus was isolated from specimens of a diseased European eel (Anguilla anguilla). This virus induced cytopathic effect in embryonic kidney cells and high mortality controlled transmission study using elvers. Eel has genome 7,496 nucleotides that encodes polyprotein 2,259 amino acids. It typical layout, but its low similarity to known viral proteins suggests species the family Picornaviridae.

10.1128/jvi.01094-13 article EN Journal of Virology 2013-07-25

SUMMARY Climate change, in particular rising temperature, is suspected to be a major driver for the emergence of many wildlife diseases. Proliferative kidney disease salmonids, caused by myxozoan Tetracapsuloides bryosalmonae , was used evaluate how temperature dependence host–parasite interactions modulates emergence. Brown trout ( Salmo trutta fario ) kept at 12 and 15 °C, were experimentally infected with T. . Parasite development fish host release spores quantified simultaneously unravel...

10.1017/s0031182017001482 article EN Parasitology 2017-08-23

Estrogenic endocrine disrupting compounds (EEDCs), such as ethinylestradiol (EE2), are well studied for their impact on the reproductive system of fish. EEDCs may also immune and, a consequence, disease susceptibility It is currently not yet known whether low concentrations that able to disrupt trout effective in and fish host resistance towards pathogens, too, or immunodisruptive effects would occur only at higher EEDC concentrations. Therefore, present study we compare effect thresholds...

10.1016/j.envint.2020.105836 article EN cc-by-nc-nd Environment International 2020-06-17

European perch (Perca fluviatilis) are increasingly farmed as a human food source. Viral infections of remain largely unexplored, thereby putting farm populations at incalculable risk for devastating fish epizootics and presenting potential hazard to consumers. To address these concerns, we applied metatranscriptomics identify disease-associated viruses in Switzerland. Unexpectedly, clinically diseased detected novel freshwater filoviruses, hantavirus, previously unknown rhabdovirus....

10.3201/eid2712.210491 article EN cc-by Emerging infectious diseases 2021-11-18

The role of water temperature and altitude the river sites on distribution, prevalence infection intensity Tetracapsuloides bryosalmonae infected salmonids was investigated. study is based a 6 year survey salmonids, mainly brown trout, Salmo trutta from 2000 to 2006 at 287 sampling across Switzerland. Almost 7000 fishes were tested for presence T. by histological immunohistochemical techniques. A good correlation between in Swiss rivers could be demonstrated. Therefore, relation investigated...

10.1111/j.1095-8649.2008.02054.x article EN Journal of Fish Biology 2008-12-01

Summary Gill disease in salmonids is characterized by a multifactorial aetiology. Epitheliocystis of the gill lamellae caused obligate intracellular bacteria order Chlamydiales one known factor; however, their diversity has greatly complicated analyses to establish causal relationship. In addition, tracing infections potential environmental source currently impossible. this study, we address these questions investigating wild brown trout ( Salmo trutta ) population from seven different sites...

10.1111/j.1462-2920.2011.02670.x article EN Environmental Microbiology 2011-12-19
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