A5081592818- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Genomics, phytochemicals, and oxidative stress
- Transgenic Plants and Applications
- Gout, Hyperuricemia, Uric Acid
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Genital Health and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Melanoma and MAPK Pathways
- PI3K/AKT/mTOR signaling in cancer
- Plant Molecular Biology Research
- Toxin Mechanisms and Immunotoxins
- Plant Gene Expression Analysis
- Plant tissue culture and regeneration
- Galectins and Cancer Biology
- Cancer Mechanisms and Therapy
- Adenosine and Purinergic Signaling
- Cell death mechanisms and regulation
- Immune cells in cancer
- Histiocytic Disorders and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Urticaria and Related Conditions
- Kawasaki Disease and Coronary Complications
University Hospital of Zurich
2018-2024
University of Zurich
2019-2022
University of Virginia
2016
University of Łódź
2016
Abstract Epigenetic regulation of cell and tissue function requires the coordinated action transcription factors. However, their combinatorial activities during regeneration remain largely unexplored. Here, we discover an unexpected interaction between cytoprotective factor NRF2 p63- a key player in epithelial morphogenesis. Chromatin immunoprecipitation combined with sequencing reporter assays identifies enhancers promoters that are simultaneously activated by p63 human keratinocytes....
NLRP1 is the primary inflammasome sensor in human keratinocytes. Sensing of UVB radiation by believed to underlie induction sunburn. Although constitutive activation causes skin inflammation and predisposes patients development cutaneous SCCs, pathway suppressed established SCCs. Here, we identified high levels autophagy receptor p62 SCC cells lines tumors. Increased NF-κB activity up-regulation. Suppression expression rescues UVB-induced early-stage cells. protects from cytotoxic drugs,...
Ribosomal S6 kinases (RSK) play important roles in cell signaling through the mitogen-activated protein kinase (MAPK) pathway. Each of four RSK isoforms (RSK1-4) is a single polypeptide chain containing two domains connected by linker sequence with regulatory phosphorylation sites. Here, we demonstrate that full-length RSK2-which implicated several types cancer, and which linked to genetic Coffin-Lowry syndrome-can be overexpressed high yields Escherichia coli as fusion maltose binding...