A5016487451- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Pediatric Pain Management Techniques
- Electrospun Nanofibers in Biomedical Applications
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Tissue Engineering and Regenerative Medicine
- Congenital Heart Disease Studies
- Tracheal and airway disorders
- Cardiac and Coronary Surgery Techniques
- Cancer Treatment and Pharmacology
- Neonatal and fetal brain pathology
- Sleep and Wakefulness Research
- Heart Rate Variability and Autonomic Control
- Nausea and vomiting management
- Cardiovascular Issues in Pregnancy
- Spinal Hematomas and Complications
- Silymarin and Mushroom Poisoning
- Pluripotent Stem Cells Research
- Cardiac Arrhythmias and Treatments
- Otitis Media and Relapsing Polychondritis
- Intraoperative Neuromonitoring and Anesthetic Effects
- Hypothalamic control of reproductive hormones
Juntendo University
2023
Tokyo Medical and Dental University
2015-2023
Jikei University School of Medicine
1973-2022
Nagoya City University
2018-2022
National Center For Child Health and Development
2008-2021
Tokyo Medical and Dental University Hospital
2015-2020
Teikyo University
2011-2018
Teikyo University Chiba Medical Center
2012-2016
Cornell University
2013
Chiba University
2012
Oxaliplatin, a chemotherapeutic agent used for the treatment of colorectal cancer, induces dose-limiting neuropathy that compromises quality life. This study aimed to reproduce, in mice, patients' symptoms oxaliplatin-induced and observe effects SS-31, mitochondria-targeted antioxidant on neuropathy.Neuropathy was induced by single or repeated injections oxaliplatin. Cold mechanical hypersensitivities were assessed 15°C-cold plate, temperature preference, von Frey tests. Morphology...
Several chemotherapeutic agents used for cancer treatment induce dose-limiting peripheral neuropathy that compromises patients' quality of life and limits treatment. Recently, mitochondrial dysfunction has been shown to be involved in the mechanism chemotherapy-induced neuropathy. SS-20 is a mitochondria-targeted peptide promotes respiration restores bioenergetics. In present study, we examined protective effect against development utilizing murine model induced by oxaliplatin, first-line...
Abstract Background Sleepiness and decrease in attention are dose-limiting side effects of opioids. The orexin/hypocretin system plays an important role maintaining wakefulness. This study aimed to explore the potential a nonpeptide orexin receptor agonist alleviate morphine-induced sedative effects. Methods Morphine were evaluated as changes electroencephalogram (EEG), locomotor activity, acoustic startle response rats (n = 5 9 per group). Effects intracerebroventricular orexin-A systemic...
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by repeated remissions and relapses. Immunosuppressive drugs have facilitated the induction maintenance of remission in many patients with UC. However, immunosuppressive cannot directly repair impaired intestinal mucosa are insufficient for preventing relapse. Therefore, new treatment approaches to damaged epithelium UC been attempted through transplantation organoids, which can be differentiated into embedding Matrigel,...
BACKGROUND:There are few reports of coronavirus disease 2019 (COVID-19) in pregnant women. Although coagulation dysfunction was reported to affect the severity COVID-19, association between pregnancy, which is usually accompanied by changes function, and worsening COVID-19 unknown. We present a case 30-year-old woman 36th week pregnancy who diagnosed with severe pneumonia required postpartum extracorporeal membrane oxygenation (ECMO) therapy. CASEREPORT:A 30-year-old, 36-weeks presented our...
Double-lumen endobronchial tubes (DLTs) are essential for differential lung ventilation during pulmonary lobectomy, but they more rigid, longer, larger in diameter and irritable. Coughing at extubation sometimes causes airway injury, which severe air leaks, prolonged cough sore throat. We examined the prevalence of cough-associated leaks postoperative or throat after lobectomy evaluated efficacy supraglottic (SGA) preventing these complications.Patient characteristics operative factors data...
We report an unusual case of massive macroglossia that developed very rapidly after neurosurgery in the park bench position with neck flexion. A few minutes endotracheal extubation, was noticed marked protrusion tongue from oral cavity. The patient's hospital stay prolonged due to difficulty speaking and eating. Macroglossia is a rare complication; however, it may cause life‐threatening airway obstruction. It important be prepared for managing post‐operative keep mind develop rapidly,...
Abstract The ultimate goal of regenerative medicine is the transplantation a target organ generated by patient's own cells. Recently, method generation using pluripotent stem cells ( PSC s) and blastocyst complementation was reported. This approach based on chimeric animal an early embryo s, contribution s to key method's success. However, rate in organs different methods remains unknown. In this study, we used 8‐cell aggregation, injection, injection generate interspecies mice rat embryonic...
<i>Background/Aims:</i> Multiple opioid receptor (OR) types and endogenous peptides exist in the spinal dorsal horn there may be interactions among these that involve peptides. In a previous study we observed antinociceptive effects of selective ĸ-opioid (ĸOR) agonist, U50,488H, was attenuated µ-opioid (µOR) knockout mice as compared to wild-type when administered spinally. This suggests an interaction between ĸORs µORs exits cord. The present aimed at investigating whether were...
It is unknown whether cerebral oxygenation in patients with carotid artery stenosis (CAS) undergoing off-pump coronary bypass grafting (CABG) differs from that without CAS. Thus, the effect of presence CAS ≥ 50 % on during CABG adult was evaluated retrospectively.Eleven 50% and 14 were enrolled. Regional tissue oxygen saturation (rSO2) quantified using near-infrared spectroscopy. Mean arterial pressure, cardiac index, central venous pressure (CVP), rSO2 at specific points collected,...
In Surviving Sepsis Campaign Guidelines 2012, noradrenalin (NA) is recommended as a first choice vasopressor. Although vasopressin (VP) for the treatment of NA-resistant septic shock, optimal parameters its administration remain unclear.We conducted retrospective study to evaluate clinical outcomes VP adult shock patients who were undergoing high-dose NA (≥0.25 μg/kg/min) therapy in our Intensive Care Unit between January 2010 and December 2013. We defined dose >0.25 μg/kg/min, based on...
Toyama, S.; Kakumoto, M.; Morioka, Matsuoka, K.; Omatsu, H.; Tagaito, Y.; Numai, T.; Shimoyama, M. Author Information
Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal and information, but is committed maintaining privacy will not share personal information without express consent. For more please refer our Privacy Policy. eTOC Secondary Logo Journal All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Login & Issues Current IssuePrevious Collections Obstetric Airway...