A5039155725- Sulfur Compounds in Biology
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Renal Transplantation Outcomes and Treatments
- Neuroscience of respiration and sleep
- Alcohol Consumption and Health Effects
- Neurological Complications and Syndromes
- Renal Diseases and Glomerulopathies
- Glutathione Transferases and Polymorphisms
- Renal function and acid-base balance
- Nutritional Studies and Diet
- Acute Myocardial Infarction Research
- Folate and B Vitamins Research
- Pregnancy and Medication Impact
- Diabetes Treatment and Management
- High Altitude and Hypoxia
- Organ Transplantation Techniques and Outcomes
- Hydrogen's biological and therapeutic effects
- Mast cells and histamine
- Antiplatelet Therapy and Cardiovascular Diseases
- Complement system in diseases
- Venous Thromboembolism Diagnosis and Management
- Chronic Kidney Disease and Diabetes
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Hypoxia, and Metabolism
University Medical Center Groningen
2013-2025
University of Groningen
2013-2025
University Medical Center Utrecht
2016
University Hospital Schleswig-Holstein
2004
University of Lübeck
2004
University of Amsterdam
1987
In the past decades three gaseous signaling molecules—so-called gasotransmitters—have been identified: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). These gasotransmitters are endogenously produced by different enzymes in various cell types play an important role physiology disease. Despite their specific functions, all share capacity to reduce oxidative stress, induce angiogenesis, promote vasorelaxation. patients with diabetes, a lower bioavailability of is observed...
Background Repeated exposure to sensitizing events can activate HLA-specific memory B cells, leading the production of donor-specific cell antibodies (DSAm) that pose a risk for antibody-mediated rejection (ABMR) in kidney transplant recipients (KTRs). This single-center retrospective study aimed identify DSAm and assess their association with outcomes cohort KTRs pretransplant serum (DSA). Methods We polyclonally activated peripheral blood mononuclear cells (PBMCs) from 60 vitro, isolated...
Background Ischemia-reperfusion injury (IRI) is a major cause of cardiac damage following various pathological processes. Gaseous hydrogen sulfide (H2S) protective during IRI by inducing hypometabolic state in mice which associated with anti-apoptotic, anti-inflammatory and antioxidant properties. We investigated whether gaseous H2S administration non-hypometabolic concentrations have similar Methods Male C57BL/6 received 0, 10, or 100 ppm H2S-N2 mixture starting 30 minutes prior to ischemia...
Abstract Background Several clinical trials have shown beneficial effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on kidney disease progression and cardiovascular morbidity mortality in patients with chronic (CKD) without type diabetes mellitus. However, some subgroups CKD been excluded from participation these trials, such as severely impaired function, dialysis, transplant recipients. Methods The Renal Lifecycle trial (NCT05374291) is a pragmatic, international, multicenter,...
ABSTRACT Repeat transplantations represent up to 20% of all kidney transplants. Whereas repeat in the presence circulating donor‐specific HLA‐antibodies are generally avoided, risk repeated HLA‐mismatches (RMM) without detectable antibodies remains debated. This multicenter study evaluated hazard RMM, stratified by HLA‐class, on transplant outcomes absence preformed antibodies. We included recipients from January 2009 onward with available HLA typing for HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3/4/5 and...
Abstract Atherosclerotic plaques are classically divided into stable and vulnerable plaques. Vulnerable prone to rupture with a risk for infarction. High intraplaque microvessel density predisposes plaque vulnerability. Hydrogen sulfide (H 2 S) is proangiogenic gasotransmitter which endogenously produced by cystathionine γ-lyase (CSE), believed have vasculoprotective effects. However, due its effects, H S may result in pathological angiogenesis atherosclerotic plaques, thereby increasing The...
Background. Evidence on the optimal maintenance of immunosuppressive regimen in kidney transplantation recipients is limited. Methods. The Amsterdam, LEiden, GROningen trial a randomized, multicenter, investigator-driven, noninferiority, open-label de novo transplant recipients, which 2 immunosuppression minimization strategies were compared with standard basiliximab, corticosteroids, tacrolimus, and mycophenolic acid. In groups, either steroids withdrawn from day 3, or tacrolimus exposure...
Aims: Thiosulfate and sulfate are metabolites of hydrogen sulfide (H2S), a gaseous signaling molecule with cardiovascular (CV) protective properties. Urinary thiosulfate excretion associated favorable disease outcome in high-risk patient groups. We investigated the relationship between urinary sulfur metabolites, risk CV events all-cause mortality general population. Results: Subjects (n = 6839) Prevention Renal Vascular End-stage Disease (PREVEND) study were followed prospectively. At...
Background: Respiratory diseases, like obstructive sleep disorder and chronic pulmonary are frequently accompanied by glucose intolerance as a critical sign of prospective metabolic disorders. The is believed to result from recurrent hypoxia. This study examined whether hypoxia cause for in healthy subjects.
Previous and recent reports have suggested a fibrinolysis-enhancing property of standard heparin (SH) low molecular weight (LMWH) but these observations never been confirmed in clinical study fulfilling appropriate methodological criteria.Aim this was to evaluate cross-over double blind placebo-controlled the effect SH LMWH (K 2165) on fibrinolysis. Six healthy volunteers (age 22-30) received bolus dose following treatments: l)Placebo, 2)Kabi SH,5000 I.U., 3) Kabi 2165,5000 anti Xa U, 4)Kabi...