A5009452728- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- COVID-19 and healthcare impacts
- COVID-19 Impact on Reproduction
- Liver Disease and Transplantation
- Long-Term Effects of COVID-19
- Mycobacterium research and diagnosis
- Herpesvirus Infections and Treatments
- Mosquito-borne diseases and control
- Clostridium difficile and Clostridium perfringens research
- Bacterial Identification and Susceptibility Testing
- Antifungal resistance and susceptibility
- Parasites and Host Interactions
- Infectious Encephalopathies and Encephalitis
- Cardiac Arrhythmias and Treatments
- Cardiovascular Issues in Pregnancy
- Toxoplasma gondii Research Studies
- Immunodeficiency and Autoimmune Disorders
- Respiratory viral infections research
- Mechanical Circulatory Support Devices
- Infectious Diseases and Mycology
- Domain Adaptation and Few-Shot Learning
- Cancer-related molecular mechanisms research
Inova Fairfax Hospital
2023-2024
Inova Health System
2024
Alaska Heart and Vascular Institute
2023
Nova Medical (United States)
2023
Northwestern University
2018-2022
Tulane University
2012
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has led to significant reductions in transplantation, motivated part by concerns of disproportionately more severe among solid organ transplant (SOT) recipients. However, clinical features, outcomes, and predictors mortality SOT recipients are not well described. Methods We performed a multicenter cohort study with laboratory-confirmed COVID-19. Data were collected using standardized intake 28-day follow-up electronic case...
Mortality among patients hospitalized for COVID-19 has declined over the course of pandemic. trends specifically in solid organ transplant recipients (SOTR) are unknown. Using data from a multicenter registry SOTR COVID-19, we compared 28-day mortality between early 2020 (March 1, 2020-June 19, 2020) and late (June 20, 2020-December 31, 2020). Multivariable logistic regression was used to assess comorbidity-adjusted mortality. Time period diagnosis available 1435/1616 (88.8%) 971/1435...
Abstract Background Cache Valley virus (CVV) is a mosquito-borne that rare cause of disease in humans. In the fall 2020, patient developed encephalitis 6 weeks following kidney transplantation and receipt multiple blood transfusions. Methods After ruling out more common etiologies, metagenomic next-generation sequencing (mNGS) cerebrospinal fluid (CSF) was performed. We reviewed medical histories index recipient, organ donor, recipients other organs from same donor conducted traceback...
Most studies of solid organ transplant (SOT) recipients with COVID-19 focus on outcomes within one month illness onset. Delayed mortality in SOT hospitalized for has not been fully examined.
Background Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing their immunosuppressed state propensity for kidney injury. The primary purpose of this study is ascertain if, recipients, infection impacts long term renal allograft function. Methods This retrospective, single-center reviewed 53 with positive SARS-CoV-2 PCR at NMH from January 1, 2020 June 30, 2020. Results Change eGFR baseline function prior 90 days after the first...
PurposeOutcomes of lung transplant recipients (LTR) hospitalized for COVID-19 and comparisons to non-lung solid organ (SOTR) are incompletely described.MethodsUsing a multicenter prospective registry SOTR, we examined 28-day outcomes (mortality [primary outcome], intensive care unit (ICU) admission, mechanical ventilation, bacterial pneumonia) among both LTR SOTR with laboratory-confirmed diagnosed between March 1, 2020 September 21, 2020. Data were analyzed using Stata (StataCorp, College...
Many institutions suspended surveillance and contact precautions for multidrug-resistant organisms (MDROs) at the outset of coronavirus disease 2019 (COVID-19) pandemic due to a lack resources. Once our institution reinstated in September 2020, vancomycin-resistant Enterococcus (VRE) faecium outbreak was detected cardiothoracic transplant units, population which we had not previously outbreaks.An investigation conducted using pulsed-field gel electrophoresis strain typing electronic medical...
Abstract Background Solid organ transplant (SOT) recipients are more susceptible to viral infection and present with differing kinetics when compared non-immunocompromised cohorts. The duration of shedding in SOT SARS-CoV-2 is unknown. Methods All a diagnosed by nasopharyngeal bronchoalveolar lavage RT-qPCR from March 06, 2020 May 31, were identified. Viral was obtained evaluating all subsequent PCR results following initial positivity over time. Severity classification defined as mild...
To describe a case of acute invasive fungal sinusitis (AIFS), unique in its presentation with limited superficial invasion, underlying crust, patient on antifungal prophylaxis. present accompanying images and pathology results that capture the very early stages invasion depict ongoing battle between organisms immune system. Case report literature review. We 74-year-old immunocompromised male prophylactic voriconazole who was admitted neutropenic fever found to have superficially sinusitis....
Background: Infection rates are high in heart transplant (HT) patients due to the need for immunosuppressive medication. MicroRNAs (miR) non-coding RNAs, that regulate gene expression and promising biomarkers identifying at risk infection. Hypothesis: MiR profiles can identify HT who increased developing an Methods: were prospectively enrolled from 2015-2018 had miR-sequencing performed. Incident infection after hospital discharge along with epidemiologic characteristics of collected EMR. An...