A5033919372- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- Glycosylation and Glycoproteins Research
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Advanced Biosensing Techniques and Applications
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Mathematical Biology Tumor Growth
National Taiwan University
2021-2024
Abstract Intratumoral heterogeneity is intrinsically comprised of molecular alterations tumor cells and extrinsically from interconnections with microenvironments. This study explores the spatial ovarian clear cell carcinoma (OCCC), a rare cancer significance to East Asian women. We profiled 21 tumors matched metastatic sites transcriptomic (ST) platforms including GeoMx Visium CytAssist. Three subclusters OCCC enriched in oxidative phosphorylation, epithelial-mesenchymal transition,...
Abstract Intrinsic intra-tumor heterogeneity (ITH) has been linked to worse patient outcomes. The development of spatial profiling technology enabled the deciphering ITH with multiple analysis readouts. Advanced ovarian clear cell carcinoma (OCCC), known harbor ITH, is chemoresistant, poor prognostic, and possesses distinct molecular histological characteristics. However, detailed information nature within OCCC remains unclear. Here, we utilized NanoString Digital (DSP) GeoMx platform...
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e17543 Background: OCCC is an ovarian cancer subtype with high incidence in Asia. Despite its frequent occurrence as early-stage disease, optimal therapeutic options for high-risk patients are limited. Recently, immune-hot features have been proposed indicator poor prognosis OCCC. Specific patterns of intra-tumoral heterogeneity (ITH) associated these yet to be defined. Methods: Formalin-fixed paraffine embedded (FFPE) tumor sections from 10 primary were included. Digital Spatial Profiling...
Abstract Introduction OCCC has high incidence in Asia with frequent occurrence at early stage but without sufficient data on molecular stratification for high-risk patients. Recently, immune-hot features have been proposed as an indicator poor prognosis early-stage OCCC. Specific patterns of intra-tumoral heterogeneity (ITH) associated need to be defined. Methods Formalin-fixed paraffine embedded (FFPE) tumor sections from 10 patients were included. Digital Spatial Profiling (DSP) 18 protein...
<h3>Introduction</h3> OCCC has high incidence in Asia with frequent occurrence at early stage but without sufficient data on molecular stratification for high-risk patients. Recently, immune-hot features have been proposed as an indicator poor prognosis early-stage OCCC. Specific patterns of intra-tumoral heterogeneity (ITH) associated need to be defined. <h3>Methods</h3> Formalin-fixed paraffine embedded (FFPE) tumor sections from 10 patients were included. Digital Spatial Profiling (DSP)...