A5081557192- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Bacterial Identification and Susceptibility Testing
- Spine and Intervertebral Disc Pathology
- Streptococcal Infections and Treatments
- Bone and Joint Diseases
- Infectious Diseases and Tuberculosis
- Scoliosis diagnosis and treatment
- Infective Endocarditis Diagnosis and Management
- Musculoskeletal synovial abnormalities and treatments
- Lower Extremity Biomechanics and Pathologies
- Surgical site infection prevention
- Medical Imaging and Analysis
- Periodontal Regeneration and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Bone fractures and treatments
- Hematological disorders and diagnostics
- Spondyloarthritis Studies and Treatments
- Listeria monocytogenes in Food Safety
Orthopaedic Hospital Valdoltra
2012-2025
University of Ljubljana
2021-2025
Streptococci are not an infrequent cause of periprosthetic joint infection (PJI). Management by debridement, antibiotics, and implant retention (DAIR) is thought to produce a good prognosis, but little known about the real likelihood success. A retrospective, observational, multicenter, international study was performed during 2003–2012. Eligible patients had streptococcal PJI that managed with DAIR. The primary endpoint failure, defined as death related infection, relapse/persistence or...
Undiagnosed low-grade prosthetic joint infections (PJI) are recognized as an important reason for early failure of presumably aseptic revisions. Preoperatively administered antimicrobial prophylaxis reduces the incidence PJI but it may reduce sensitivity microbiologic periprosthetic tissue cultures and consequently increase undiagnosed septic failures, which can lead to catastrophic serial revisions.We wished determine whether administration preoperative antibiotics decreases likelihood...
Mesenchymal stem/stromal cells (MSCs) can replenish the aged of musculoskeletal system in adult life. Stem cell exhaustion and decrease their regenerative potential have been suggested to be hallmarks aging. Here, we investigated whether muscle- bone-derived MSCs patients with osteoarthritis osteoporosis are affected by this exhaustion, compared healthy donors.Patients primary osteoarthritis, femoral neck fractures due osteoporosis, donors (controls) were included. isolated from skeletal...
Mesenchymal stem/stromal cells (MSCs) are being exploited for patient-derived stem-cell therapies. As the biological properties of MSCs derived from skeletal muscle osteoarthritis patients poorly understood, aim this study was to compare with well-recognized bone and marrow-derived these patients. Paired samples trabecular tissue were obtained 21 osteoarthritis. Isolated compared using ex vivo immunophenotyping detailed in vitro analyses. These included colony forming unit fibroblast assay,...
Synovial fluid white blood cell (WBC) count and percentage of polymorphonuclear cells (%PMN) are elevated at periprosthetic joint infection (PJI). Leucocytes produce different interleukins (IL), including IL-6, so we hypothesized that synovial IL-6 could be a more accurate predictor PJI than WBC %PMN. The main aim our study was to compare the predictive performance all three diagnostic tests in detection PJI.Patients undergoing total hip or knee revision surgery were included. In...
Human skeletal stem cells (hSSCs) were recently identified as podoplanin (PDPN)/CD73/CD164-positive and CD146-negative that decline with age, play a role in the pathogenesis of osteoarthritis (OA). The aim this study was to identify hSSC-like properties bone-derived mesenchymal stem/stromal (MSCs) patients late early OA. Methods: First, we performed gene expression profiling for hSSC markers 32 OA, donors without Having low OA patients, further trilineage differentiation immunophenotyping...
Background and purpose — The accuracy of conventional navigation systems depends on precise registration bony landmarks. We investigated the clinical use electromagnetic (EMN), with a unique device for determination anterior pelvic plane.Patients methods randomly allocated patients scheduled total hip arthroplasty into 2 groups 42 each. In study group, cups were placed at predetermined target angles (inclination: 42.5°; anteversion: 15°) support EMN. control freehand aiming same angles....
Periacetabular osteotomy (PAO) for pelvic fracture sequelae presents a challenge in hip preservation surgery due to combination of complex conditions involving post-traumatic altered anatomy and technically demanding procedure, with high surgical risk involved. To address these challenging evade potential devastating complications, patient-specific template (PST) electromagnetic navigation (EMN) guidance can be used increase the safety procedure accuracy acetabular reorientation. Herein we...
Case: A 59-year-old man with previously well-functioning partial knee replacement was admitted a warm, swollen, and painful knee. The clinical presentation consistent prosthetic joint infection (PJI), but the synovial fluid analysis negative for microbial growth. Further discussion revealed earlier Campylobacter jejuni enterocolitis that subsequently provoked reactive arthritis (ReA) mimicking PJI. patient treated oral naproxen intra-articular injection of triamcinolone recovered completely...
Case: A 64-year-old male patient sustained a fracture of the humeral diaphysis on falling from bicycle. During surgery, pus drainage intramedullary canal indicated infection, and cultures were positive for pansensitive Clostridium perfringens . After initial stabilization, imaging showed inadequate fragment contact, leading to referral our bone infection unit. revision surgery with plate osteosynthesis was performed. Intravenous oral antibiotic therapy administered. Oral antibiotics...
Aim Periprosthetic joint infection (PJI) is one of the most devastating complications after replacement. It associated with high morbidity and economic burden when misdiagnosed as an aseptic failure. Among all cases PJI, up to 25% could yield negative cultures. Conversely, among failures, 30% may actually be undiagnosed PJIs. In PJIs microbiological diagnosis a key step for successful treatment. Sonication removed prosthesis more sensitive than conventional periprosthetic-tissue culture,...
Aim Arthroscopic interventions have revolutionized the treatment of joint pathologies. The appropriate diagnostics and are required for infections after ligament reconstructions using non-resorbable material such as tendon grafts, anchors, sutures, prone to biofilm formation. infection rate is around 1% knee shoulder, while up 4% Achilles reconstructions. Despite high number these procedures worldwide, there limited evidence about best protocol. Our study aimed provide a general protocol...
Background: Listeria monocytogenes causes bacteraemia in elderly and immunocompromised patients rarely also immunocompetent patients. In sporadic setting it can be challenging to diagnose. We present the first case of infection presenting as an acute a prosthetic joint patient. Case summary: An patient presented with onset right hip pain lasting for 3 days. The day before admission had fever 38.5°C chills. admitted having eaten raw meat some days prior symptoms. He implanted due secondary...
Infection is becoming the most important as well devastating mechanism of prosthetic joint failure. The incidence increasing due to increased sensitivity orthopedic surgeons for this diagnosis, better diagnostics, and because absolute number operated patients more often very sick, debilitated, immunocompromised are on. trend shows further increase in years come. diagnosis may be easy case high grade processes, but also extremely difficult low infections. Misdiagnosing infection leads repeat...