A5100352046- Ginseng Biological Effects and Applications
- Marine and coastal ecosystems
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Biochemical Analysis and Sensing Techniques
- Cancer-related gene regulation
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Heavy Metal Exposure and Toxicity
- Wnt/β-catenin signaling in development and cancer
- Synthesis and properties of polymers
- Pulmonary Hypertension Research and Treatments
- Hedgehog Signaling Pathway Studies
- Kruppel-like factors research
- Neuroinflammation and Neurodegeneration Mechanisms
- Constructed Wetlands for Wastewater Treatment
- Wastewater Treatment and Nitrogen Removal
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Epigenetics and DNA Methylation
- Cannabis and Cannabinoid Research
- Adenosine and Purinergic Signaling
- Bone Metabolism and Diseases
Nanchang University
2023-2025
Baoding People's Hospital
2025
Biodiversity Research Center, Academia Sinica
2024-2025
University of Colorado Denver
2022-2025
Hunan University
2025
Guangdong University of Technology
2025
Shanghai Institute of Organic Chemistry
2024-2025
University of Chinese Academy of Sciences
2024-2025
Zhengzhou University
2025
Chongqing Medical University
2017-2024
Netrin-1 binds to the high-affinity receptor CD146 activate downstream signaling and angiogenesis. Here, we examine role underlying mechanisms of G protein subunit alpha i1 (Gαi1) Gαi3 in Netrin-1-induced pro-angiogenic activity. In mouse embryonic fibroblasts (MEFs) endothelial cells, Akt-mTOR (mammalian target rapamycin) Erk activation was largely inhibited by silencing or knockout Gαi1/3, whereas augmented following Gαi1/3 overexpression. induced association with CD146, required for...
Androgen and estrogen, key sex hormones, were long thought to be exclusively produced by vertebrates. The O2-dependent aromatase that converts androgen estrogen (estrogenesis) has never been identified in any prokaryotes. Here, we report the finding of anaerobic estrogenesis a Peptococcaceae bacterium (Phosphitispora sp. strain TUW77) isolated from gut great blue-spotted mudskipper (Boleophthalmus pectinirostris). This exhibits testosterone fermentation pathways, transforming into estrogens...
Nonalcoholic fatty liver disease (NAFLD) is one of the common diseases in world, and it can progress from simple lipid accumulation to sustained inflammation. The present study was designed investigate effects underlying mechanisms ginsenoside Rg1 (G-Rg1) treatment on NAFLD vitro . HepG2 cells were treated with palmitic acid (PA) induce steatosis inflammation then successively incubated G-Rg1. Lipids analyzed by Oil Red O staining intracellular triglyceride (TG) quantification. Inflammatory...
Abstract l -Threonine is an important feed additive with the third largest market size among amino acids produced by microbial fermentation. The GRAS (generally regarded as safe) industrial workhorse Corynebacterium glutamicum attractive chassis for -threonine production. However, present production in C. cannot meet requirement of industrialization due to relatively low level and accumulation large amounts by-products (such -lysine, -isoleucine, glycine). Herein, enhance biosynthesis ,...
The relationship between diabetes and endothelial dysfunction remains unclear, particularly the association with pathological activation of calpain, an intracellular cysteine protease. Here, we used human induced pluripotent stem cells-derived cells (iPSC-ECs) to investigate effects on vascular health. Our results indicate that iPSC-ECs exposed hyperglycemia had impaired autophagy, increased mitochondria fragmentation, was associated calpain activity. In addition, hyperglycemic...
Remyelination failure is a crucial component of disease progression in the autoimmune demyelinating Multiple Sclerosis (MS). The regenerative capacity oligodendrocyte progenitor cells (OPCs) to replace myelinating oligodendrocytes likely influenced by many aspects lesion environment including inflammatory signaling and extracellular matrix (ECM) deposition. These features MS lesions are typically attributed infiltrating leukocytes reactive astrocytes. Here we demonstrate that fibroblasts...
Ginsenoside Rg1 (G‑Rg1) is an active ingredient of Panax ginseng, which has previously been reported to attenuate alcohol‑induced hepatic damage; however, the underlying mechanisms remain largely unknown. The present study aimed investigate protective effects G‑Rg1 on cell injury in vitro and a rat model alcoholic hepatitis vivo. For model, L‑O2 cells were incubated with ethanol presence or absence G‑Rg1. vivo rats administered by intragastric injection treated G‑Rg1, dexamethasone as...
Ulcerative colitis (UC), as an intractably treated disease, seriously affects the quality of life patients and has increase in terms incidence prevalence annually. However, due to lack a direct etiology drug-induced side effects, medical treatment UC falls into bottleneck. There are many natural phytochemicals with potential regulate immune function nature. Herein, mechanism artemisinin druggability compounds peroxide bond were discussed predicted based on computer-aided drug design (CADD)...
Abstract Kuroshio intrusion into the South China Sea (SCS) varies seasonally and interannually under different climatic conditions. To characterize intensity of climate‐driven its impact on phytoplankton community in northeastern (NESCS), two cruises were conducted during 2015/16 El Niño event. In situ observations remote sensing data showed that strongly intruded SCS both summer winter. The was dominated by cyanobacteria ( Trichodesmium erythraeum ), associated with high surface...
Paclitaxel is often used in combination with small molecule kinase inhibitors to enhance antitumor efficacy against various malignancies. Because paclitaxel metabolized by CYP2C8 and CYP3A4, the possibility of drug–drug interactions mediated enzyme inhibition may exist between combining agents. In present study, a total 12 were evaluated for inhibitory potency human liver microsomes monitoring formation CYP3A4 metabolites simultaneously. For reversible inhibition, nilotinib was found be most...
In previous studies, NOX4, PDE11A and GHR genes have been screened as important candidate for litter size in sheep by using the GWAS method; however, neither their effects on nor loci associated with identified. this study, three (c.1057-4C > T c.1983C c.1618C GHR) were first based our resequencing data of 10 breeds. After genotyped Sequenom MassARRAY technology, we carried out population genetics analysis performed association between polymorphism sheep. The results suggested that...
Lead (Pb), mercury (Hg), and cadmium (Cd) are prevalent persistent environmental contaminants, causing detrimental effects on millions of individuals worldwide. Our previous research demonstrated that early-life exposure to low-level Pb, Hg, Cd mixtures may lead cognitive impairments. However, the association interaction among low levels or remains unclear. In this study, a two-level full factorial design (5.481, 0.036, 2.132 mg/L for respectively) was conducted assess interplay maternal...
BACKGROUND Administering anesthesia to elderly patients undergoing gastroenteroscopy necessitates careful attention due age-related physiological changes and an increased risk of complications. AIM To analyze the research trends in management for gastroenteroscopy. METHODS We performed a literature search using Web Science database identify articles published between 2004 2023. Bibliometric visual analyses were conducted CiteSpace, R, VOSviewer explore current landscape administration...