Abstract The ever‐growing interest for finding efficient and reliable methods treatment of diseases has set a precedent the design synthesis new functional hybrid materials, namely porous nanoparticles, controlled drug delivery. Mesoporous silica nanoparticles (MSNPs) represent one most promising nanocarriers delivery as they possess interesting chemical physical properties, thermal mechanical stabilities, are biocompatibile. In particular, their easily functionalizable surface allows large...

Conductivity and permittivity of the quasi-one-dimensionsional organic transfer salt (TMTTF)2PF6 have been measured at low frequencies (10^3-10^7 Hz) between room temperature down to below transition into spin-Peierls state. We interpret huge real part dielectric (up 10^6) in localized state as realization this compound a charge ordered Wigner crystal type due long range Coulomb interaction.

Two monotrialkoxysilylated compounds that consist of complementary fragments melamine (M) and cyanuric acid (CA) have been synthesised. The molecular recognition properties the M CA through hydrogen bonds (DAD ADA; D=donor, A=acceptor) are key factor used to direct formation hybrid silica materials by using a sol-gel process. These were synthesised following two methods: First, an organo-bridged silsesquioxane was obtained hydrolysis derivatives, with fluoride ions as catalyst....

Abstract The synthesis of organo‐functionalized polyhedral oligomeric silsesquioxanes (POSS, (R‐SiO 1.5 ) n , T is an area significant activity. To date, 14 the largest such cage synthesized and isolated as a single isomer. Herein, we report unprecedented, single‐isomer styryl‐functionalized 18 POSS. Unambiguously identified among nine possible isomers by multinuclear solution NMR ( 1 H, 13 C, 29 Si), MALDI‐MS, FTIR, computational studies, this functionalized compound to date. A ring‐strain...

Three new series comprising 24 novel cationic choline analogues and consisting of mono- or bis (N C-5-duplicated) thiazolium salts have been synthesized. Bis-thiazolium showed potent antimalarial activity (much superior to monothiazoliums). Among them, bis-thiazolium 12 13 exhibited IC50 values 2.25 nM 0.65 nM, respectively, against P. falciparum in vitro. These compounds also demonstrated good vivo (ED50 ≤ 0.22 mg/kg), low toxicity mice infected by Plasmodium vinckei.

An organic molecule, (EtO)3Si(CH2)3NH(CO)NH–(CH2)12–NH(CO)NH(CH2)3Si(OEt)3, combining urea functionalities and a 12-carbon alkyl chain, underwent sol–gel reactions in the presence of an acid catalyst, large excess water variable amounts EuCl3, giving rise to formation crystalline hybrids through self-directed organization process which hydrogen bonding interactions play key role. Three photoluminescent lamellar Eu3+-doped silsesquioxane incorporating 1.01, 1.83 15.04% Eu3+ were prepared...

Abstract Mesoporous silica nanoparticles (MSNPs) are functionalized with molecular‐recognition sites by anchoring a triazine or uracil fragment on the surface. After loading these MSNPs dyes (propidium iodide rhodamine B) drug (camptothecin, CPT) they capped complementary fragments, and adenine, respectively, linked to bulky cyclodextrin ring. These pH‐sensitive indeed, dye release was observed at acidic pH continuously monitored fluorescence spectroscopy studies. On other hand, no leakage...

A molecular approach to information storage employs redox-active molecules tethered an electroactive surface. Zinc porphyrins Au(111) or Si(100) provide a benchmark for studies of storage. Three sets have been synthesized the interplay design and charge-storage properties: (1) set is described probing effect surface attachment atom on electron-transfer kinetics. Each porphyrin bears meso-CH2X group where X = OH, SAc, SeAc. (2) studying surface-charge density in monolayers. benzyl alcohol...

A molecular approach to information storage employs redox-active molecules tethered an electroactive surface. Attachment of the surfaces requires control over nature tether (linker and surface attachment group). We have synthesized a collection bearing different linkers anchor groups in free or protected form (hydroxy, mercapto, S-acetylthio, Se-acetylseleno) for such as silicon, germanium, gold. The exhibit number cationic oxidation states, including one (ferrocene), two...

The bridged silsesquioxane precursor (EtO)3Si(CH2)3NH(C═O)NH-(CH2)12-NH(C═O)NH(CH2)3 Si(OEt)3, combining polymerizable silylated groups, urea functionalities, and alkyl chains, undergoes fluoride (F−)-catalyzed sol−gel reactions in the presence or absence of EuCl3·6H2O. Supramolecular self-assembly growing structure relies primarily on establishment strong ordered hydrogen bonding interactions. In case Eu3+-containing hybrids lanthanide ions play a totally unparallel dual-role acting...

Herein we report the synthesis of a new family styryl-functionalized polyhedral oligomeric silsesquioxanes (Tn, where n = 8, 10, and 12), in which organic moiety is linked to all vertices Tn cages via phenyl ring rather than vinyl group. In contrast earlier studies styryl group cage moiety, our approach ensures that less sterically hindered available for postfunctionalization. The functional have been characterized by range techniques, including single crystal X-ray diffraction, multinuclear...

We present a model for predicting 29Si NMR chemical shifts (δ) in polyhedral oligomeric silsesquioxanes (POSS) and siloxanes (POS) incorporating rings with 3, 4, 5 and/or 6 Si atoms. The model, based on the spectra of POSS/POS compounds 30 different functional groups, relies observation that influence ring strain δ is essentially independent group attached to polyhedra. It anticipated such correlations would be value attributing new POSS POS compounds.

Hollow Periodic Mesoporous Organosilica Nanoparticles (HPMOs) with a controlled core cavity and (PMO) shell have been elaborated using dual templating approach. A dense silica hard...

The nature of the attractive electron-electron interaction, leading to formation Cooper-pairs in unconventional superconductors has still be fully understood and is subject intensive research. Here we show that sequence spin-Peierls, antiferromagnetism, superconductivity observed (TMTTF)_2PF_6 under pressure makes (TM)_2X phase diagram universal. We argue suppression spin-Peierls transition pressure, close vicinity antiferromagnetic superconducting phases at high as well existence critical...

A pH-responsive bridged silsesquioxane was obtained via the sol−gel process from a bis-silylated triazine derivative bearing triple DAD (donor−acceptor−donor) moiety which strongly hydrogen-bonded to three ADA (acceptor−donor−acceptor) sites of cyanuric acid. The latter template molecule easily removed resulting hybrid material upon acidic treatment, yielded template-free with preserved morphology and unaltered particle size as demonstrated by SEM. As expected, surface area acid-treated...

The self-assembly of a bis-urea phenylene-bridged silsesquioxane precursor during sol-gel synthesis has been investigated by in situ infrared spectroscopy, optical microscopy, and light scattering. In particular, the evolution system as function processing time was correlated with covalent interactions associated increasing polycondensation noncovalent such hydrogen bonding. A comprehensive mechanism based on hydrolysis organosilane prior to crystallization corresponding bridged via...

The first observation of fluxional covalent Si⋯F interactions in functionalised T₈-F cage silsesquioxanes containing an encapsulated fluoride is reported.

Organosilicas based on adenine (A) and thymine (T) assemblies have been synthesized. A surfactant-free route, specific molecular recognition between T entities, has developed. The characterization of the H-bond networks, in both homo- hetero-assemblies, emphasized by using 1H solid state NMR (nuclear magnetic resonance). latest experimental developments were implemented (i.e. very fast MAS (magic angle spinning) experiments at 750 MHz 33 kHz), order to enhance drastically spectral...

Diurea cross-linked bridged silsesquioxanes (BSs) C(10)C(n)C(10) derived from organosilane precursors, including decylene chains as side spacers and alkylene with variable length central (EtO)(3)Si-(CH(2))(10)-Y-(CH(2))(n)-Y-(CH(2))(10)-Si(OEt)(3) (n = 7, 9-12; Y urea group Et ethyl), have been synthesized through the combination of self-directed assembly an acid-catalyzed sol-gel route involving addition dimethylsulfoxide (DMSO) a large excess water. This new family hybrids has enabled us...

Despite the versatility of periodic mesoporous organosilicas (PMOs), bactericide capacity these hybrid platforms has seldom been explored. Herein, we describe synthesis large-pore phenylene-bridged PMOs, mesostructured by polyion complex (PIC) micelles (PICPMOs) incorporating an antibiotic, neomycin B. A key feature this approach is that bioactive molecules are directly encapsulated within PICPMOs during their formation. The engineered exhibit a well-ordered hexagonal mesophase with...

Abstract Hybrid organic‐inorganic thin films exhibiting patterned structuring on the nanometer scale have been prepared through controlled hydrolysis‐condensation of enantiomerically pure chiral urea‐based silyl compounds. The are obtained by spin‐coating sols via acid‐ or base‐catalyzed hydrolytic condensation these molecular precursors. A self‐templating process is demonstrated atomic force and transmission electron microscopy, showing formation size aggregates consisting interconnected...