A5077871638- Photoreceptor and optogenetics research
- Photosynthetic Processes and Mechanisms
- Advanced Algorithms and Applications
- Quantum Dots Synthesis And Properties
- Algal biology and biofuel production
- Single-cell and spatial transcriptomics
- Gene Regulatory Network Analysis
- solar cell performance optimization
- Lipid Membrane Structure and Behavior
- Inertial Sensor and Navigation
- Genomics and Phylogenetic Studies
- Advanced Chemical Sensor Technologies
- Advanced Sensor and Control Systems
- Molecular Communication and Nanonetworks
- Power Systems and Renewable Energy
- Magnetic Bearings and Levitation Dynamics
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Microbial Fuel Cells and Bioremediation
- Geochemistry and Geologic Mapping
- Supramolecular Self-Assembly in Materials
- Porphyrin and Phthalocyanine Chemistry
- Cancer Genomics and Diagnostics
University of Warwick
2021-2024
University of Bristol
2016-2020
Engineering and Physical Sciences Research Council
2019
Biotechnology and Biological Sciences Research Council
2019
University of Oxford
2019
At Bristol
2017
Chang Industry (United States)
2009-2011
Acoustically trapped periodic arrays of horseradish peroxidase (HRP)-loaded poly(diallydimethylammonium chloride) / adenosine 5'-triphosphate coacervate microdroplet-based protocells exhibit a spatiotemporal biochemical response when exposed to codiffusing mixture substrate molecules (o-phenylenediamine (o-PD) and hydrogen peroxide (H2O2)) under nonequilibrium conditions. Unidirectional propagation the chemical concentration gradients gives rise time- position-dependent fluorescence signal...
Abstract Natural photosynthesis can be divided between the chlorophyll-containing plants, algae and cyanobacteria that make up oxygenic phototrophs a diversity of bacteriochlorophyll-containing bacteria anoxygenic phototrophs. Photosynthetic light harvesting reaction centre proteins from both kingdoms have been exploited for solar energy conversion, fuel synthesis sensing technologies, but abilities these devices are limited by each protein’s individual palette pigments. In this work we...
Photoreaction centers facilitate the solar energy transduction at heart of photosynthesis and there is increasing interest in their incorporation into biohybrid devices for conversion, sensing, other applications. In this work, self-assembly conjugates between engineered bacterial reaction (RCs) quantum dots (QDs) that act as a synthetic light harvesting system described. The interface protein QD provided by polyhistidine tag confers tight specific binding defines geometry interaction....
Many strategies for meeting mankind's future energy demands through the exploitation of plentiful solar have been influenced by efficient and sustainable processes natural photosynthesis. A limitation affecting conversion based on photosynthetic proteins is selective spectral coverage that consequence their particular pigmentation. Here we demonstrate bottom-up formation semisynthetic, polychromatic photosystems in mixtures chlorophyll-based LHCII major light harvesting complex from oxygenic...
Reaction centers (RCs) are the pivotal component of natural photosystems, converting solar energy into potential difference between separated electrons and holes that is used to power much biology. RCs from anoxygenic purple photosynthetic bacteria such as Rhodobacter sphaeroides only weakly absorb visible region spectrum, which limits their overall light-harvesting capacity. For in vitro applications biohybrid photodevices, this deficiency can be addressed by effectively coupling with...
RNA-seq, including single cell RNA-seq (scRNA-seq), is plagued by insufficient sensitivity and lack of precision. As a result, the full potential (sc)RNA-seq limited. Major factors in this respect are presence global bias most datasets, which affects detection quantitation RNA length-dependent fashion. In particular, scRNA-seq affected technical noise high rate dropouts, where vast majority original transcripts not converted into sequencing reads. We discuss these biases origins...
A challenge associated with the utilisation of bioenergetic proteins in new, synthetic energy transducing systems is achieving efficient and predictable self-assembly individual components, both natural man-made, into a functioning macromolecular system. Despite progress water-soluble proteins, programming integral membrane non-native architectures remains largely unexplored. In this work it shown that assembly dimers, trimers or tetramers naturally monomeric purple bacterial reaction centre...
Reaction centre/light harvesting proteins such as the RCLH1X complex from Rhodobacter sphaeroides carry out highly quantum-efficient conversion of solar energy through ultrafast transfer and charge separation, these pigment-proteins have been incorporated into biohybrid photoelectrochemical cells for a variety applications. In this work we demonstrate that, despite not being able to support normal photosynthetic growth sphaeroides, an engineered variant lacking PufX protein with enlarged...
Abstract This article presents the experience of a team students and academics in developing post-graduate training program new field Synthetic Biology. Our Centre for Doctoral Training Biology (SynBioCDT) is an initiative funded by United Kingdom’s Research Councils Engineering Physical Sciences (EPSRC), Biotechnology Biological (BBSRC). SynBioCDT collaboration between Universities Oxford, Bristol Warwick, has been successfully running since 2014, 78 this field. In work, we discuss...
ScRNA-seq datasets for cells expressing CTDmutant RNA polymerase II (Pol II)Transcriptional bursting is robust to Pol CTD alterations N-terminal
Natural photosynthesis can be divided between the chlorophyll-containing plants, algae and cyanobacteria that make up oxygenic phototrophs a diversity of bacteriochlorophyll-containing bacteria anoxygenic phototrophs. Photosynthetic light harvesting reaction centre proteins from both groups organisms have been exploited in wide range biohybrid devices for solar energy conversion, fuel synthesis variety sensing technologies, but abilities these are limited by each protein’s individual palette...
Abstract Reaction centers (RCs) are the pivotal component of natural photosystems, converting solar energy into potential difference between separated electrons and holes that is used to power much biology. RCs from anoxygenic purple photosynthetic bacteria such as Rhodobacter sphaeroides only weakly absorb visible region spectrum which limits their overall light-harvesting capacity. For in vitro applications bio-hybrid photodevices this deficiency can be addressed by effectively coupling...