A5043500102- Speech and Audio Processing
- Speech Recognition and Synthesis
- Music and Audio Processing
- Data Management and Algorithms
- Distributed systems and fault tolerance
- Natural Language Processing Techniques
- Caching and Content Delivery
- Peer-to-Peer Network Technologies
- Optimization and Search Problems
- Distributed and Parallel Computing Systems
- Autophagy in Disease and Therapy
- Biomedical Text Mining and Ontologies
- Blind Source Separation Techniques
- Analytical Chemistry and Sensors
- Advanced Text Analysis Techniques
- RNA modifications and cancer
- Advanced Database Systems and Queries
- Topic Modeling
- Mobile Agent-Based Network Management
- Web Data Mining and Analysis
- Caveolin-1 and cellular processes
- Human Mobility and Location-Based Analysis
- Mitochondrial Function and Pathology
- User Authentication and Security Systems
- Data Mining Algorithms and Applications
Catholic University of Korea
2020-2025
Ajou University
2020-2023
Seoul St. Mary's Hospital
2022
Korea National Open University
2022
Korea University
2009-2021
Kyungpook National University
2013-2021
Korea Institute of Industrial Technology
2019-2021
Inha University
2021
Nune Eye Hospital
2015
Hanshin University
2008
The lipid-rafts hypothesis proposes that naturally occurring lipid aggregates exist in the plane of membrane are involved signal transduction, protein sorting, and transport. To understand their roles cell biology, a direct visualization such domains living cells is essential. For this purpose, 6-dodecanoyl-2-(dimethylamino)naphthalene (laurdan), probe sensitive to polarity membrane, has often been used. We have synthesized characterized...
“Green” emission: A novel two-photon fluorescent probe that can detect intracellular free Mg2+ ions at a depth of few hundred micrometers in live tissue was developed. The emission from the Mg2+–probe complex (green) shows little interference association with other metal or cell membrane (blue).
In order to detect and identify ubiquitous lipid raft marker proteins, we isolated rafts from different mouse organs, including the liver, lung, large brain, kidney, analyzed their proteins via 2-DE. Many protein spots were determined be in all of rafts, annotated LC MS/MS. Twelve identified as most these mitochondrial mortalin, prohibitin, voltage-dependent anion channel, ATP synthase, NADH dehydrogenase, ubiquinol-cytochrome c reductase. Via immunoblotting, shown exist detergent-resistant...
Although Alzheimer's disease (AD) is the most common neurodegenerative disease, there are still no drugs available to treat or prevent AD effectively. Here, we examined changes in levels of selected proteins implicated pathogenesis using plasma samples control subjects and patients with cognition impairment. To precisely categorize fifty-six participants were clinical cognitive tests, amyloid positron emission tomography (PET) scan, white matter hyperintensities scored by magnetic resonance...
In this study, a polyethyleneimine (PEI)-functionalized carbon nanotube (CNT) sensor was fabricated for dioxide detection at room temperature. Uniform CNT thin films prepared using filtration method were used as resistive networks. PEI, which contains amino groups, can effectively react with CO2 gas by forming carbamates temperatures. The morphology of the observed, and properties analyzed scanning electron microscope (SEM), Raman spectroscopy, fourier transform infrared (FT-IR)...
Recently, many methods based on deep learning have been proposed for music source separation. Some state-of-the-art shown that stacking layers with skip connections improve the SDR performance. Although such a and complex architecture shows outstanding performance, it usually requires numerous computing resources time training evaluation. This paper proposes two-stream neural network demixing, called KUIELab-MDX-Net, which good balance of performance required resources. The model has...
Recent deep-learning approaches have shown that Frequency Transformation (FT) blocks can significantly improve spectrogram-based single-source separation models by capturing frequency patterns. The goal of this paper is to extend the FT block fit multi-source task. We propose Latent Source Attentive (LaSAFT) capture source-dependent also Gated Point-wise Convolutional Modulation (GPoCM), an extension Feature-wise Linear (FiLM), modulate internal features. By employing these two novel...
Tripartite motif (TRIM) proteins are a large family of E3 ubiquitin ligases implicated in antiviral defense systems, tumorigenesis, and protein quality control. TRIM contribute to control by regulating the ubiquitin-proteasome system, endoplasmic reticulum-associated degradation, macroautophagy/autophagy. However, detailed mechanisms through which various regulate downstream events have not yet been fully elucidated. Herein, we identified novel function TRIM22 regulation autophagy. promotes...
KRIBB11, a heat shock factor1 (HSF1) inhibitor, sensitizes cancer cells to several anticancer drugs. We have previously demonstrated that KRIBB11 alone induced the apoptosis of A172 glioblastoma cells. However, molecular basis its activity remains unclear. Hence, we aimed examine alterations in cell cycle regulators and relevance HSF1 following treatment The expression levels p21, p27, p53 were determined using western blotting or real-time PCR. Alterations p27 small interfering RNA...
A carbon fiber reinforced thermoplastic (CFRTP) was irradiated with a high energy electron-beam. As result, the tensile strength of high-density polyethylene (HDPE)-based CFRTPs significantly improved by gradually increasing electron-beam dose. It confirmed that adhesion between CF and HDPE surface properties were readily modified verified from spectroscopic analysis various oxygen-containing functional groups formed on irradiation we believe strong attractive interactions took place among...
To investigate the regulation of matrix metalloproteinase (MMP)-3 and MMP-13 expression over time in presence cyclosporine A (CsA) primary cultured human pterygium fibroblasts. We also examined effects CsA on fibroblasts.Primary fibroblasts subjected to scratch assays were exposed 1 100 µg/mL for 3 or 10 minutes. Cells washed with Dulbecco phosphate-buffered saline, then incubated serum-depleted modified Eagle medium/F-12 medium 48 hours. Expression levels MMP-3 proteins corresponding mRNA...
Singing Voice Separation (SVS) tries to separate singing voice from a given mixed musical signal. Recently, many U-Net-based models have been proposed for the SVS task, but there were no existing works that evaluate and compare various types of intermediate blocks can be used in U-Net architecture. In this paper, we introduce variety spectrogram transformation blocks. We implement U-nets based on these train them complex-valued spectrograms consider both magnitude phase. These networks are...
Hereditary spastic paraplegia–associated mutations in a WASH complex component impair integrin-mediated cell adhesion.
"Grüne" Emission: Mit einer neuartigen Zweiphotonen-Fluoreszenzsonde gelingt der Nachweis von intrazellulären freien Mg2+-Ionen in lebendem Gewebe Tiefe einigen hundert Mikrometern. Die Emission des Mg2+-Sonden-Komplexes (grün) wird kaum durch die Assoziation Sonde mit anderen Metallionen oder Zellmembran (blau) gestört.
Since detergent-resistant lipid rafts play important roles in the signal transduction for myogenesis, their comprehensive proteomic analysis could provide new insights to understand function myotubes. Here, were isolated from C2C12 myotubes and analyzed by capillary RPLC/MS/MS. Among 327 proteins (or protein groups) identified, 28% categorized plasma membrane or raft proteins, 29% mitochondria, 20% microsomal 10% other 13% unknown proteins. The localization of oxidative phosphorylation...
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in cholesterol biosynthesis. HMG-CoA converts to mevalonate, which then converted into or various isoprenoids through multiple enzymatic steps. In this study, we examined cytotoxic effects of lovastatin, an inhibitor, C6 glial cells. Lovastatin at concentrations higher than 10 microM suppressed cell proliferation and induced death, were prevented completely by mevalonate (300 microM). The data from lactate...
Splicing factor B subunit 4 (SF3B4), a component of the U2-pre-mRNA spliceosomal complex, contributes to tumorigenesis in several types tumors. However, oncogenic potential SF3B4 lung cancer has not yet been determined. The
A peer-to-peer grid computing is complicated by heterogeneous capabilities, failures, volatility, and lack of trust because it based on desktop computers at the edge Internet. In order to improve reliability computation gain better performance, a replication mechanism must adapt these distinct features. other words, required classify volunteers into groups that have similar properties then dynamically apply different algorithms each group. However, existing mechanisms do not provide such per...