A5063713898- Animal Nutrition and Physiology
- Antibiotics Pharmacokinetics and Efficacy
- Turtle Biology and Conservation
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Veterinary Pharmacology and Anesthesia
- Reproductive tract infections research
- Urinary Tract Infections Management
- Meat and Animal Product Quality
- Animal Behavior and Welfare Studies
- Rabies epidemiology and control
- Antimicrobial Resistance in Staphylococcus
- Pharmacological Effects and Assays
- Bacterial Infections and Vaccines
- Agricultural safety and regulations
- Appendicitis Diagnosis and Management
- Food and Agricultural Sciences
- Cardiac electrophysiology and arrhythmias
- Phytoestrogen effects and research
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Ruminant Nutrition and Digestive Physiology
- Syphilis Diagnosis and Treatment
- Rabbits: Nutrition, Reproduction, Health
Tetraphase Pharmaceuticals (United States)
2018-2020
Entasis Therapeutics (United States)
2015-2018
AstraZeneca (United States)
2014-2015
American Pharmacists Association
2012
Tufts Medical Center
1993-2011
Tufts University
1993-2009
Kansas State University
2003-2007
Département Santé Animale
2002
Arkansas Agricultural Experiment Station
2002
Deaconess Hospital
1997
Antibiotic-resistant Neisseria gonorrhoeae has prompted the development of new therapies. Zoliflodacin is a antibiotic that inhibits DNA biosynthesis. In this multicenter, phase 2 trial, zoliflodacin was evaluated for treatment uncomplicated gonorrhea.
Increasing antimicrobial resistance among pathogens that cause complicated intraabdominal infections (cIAIs) supports the development of new antimicrobials. Eravacycline, a novel member fluorocycline family, is active against multidrug-resistant bacteria including extended-spectrum β-lactamase (ESBL) and carbapenem-resistant Enterobacteriaceae.IGNITE4 was prospective, randomized, double-blind trial. Hospitalized patients with cIAI received either eravacycline 1 mg/kg every 12 hours or...
Abstract With the diminishing effectiveness of current antibacterial therapies, it is critically important to discover agents that operate by a mechanism circumvents existing resistance. ETX0914, first new class agent targeted for treatment gonorrhea, operates novel mode-of-inhibition against bacterial type II topoisomerases. Incorporating an oxazolidinone on scaffold mitigated toxicological issues often seen with topoisomerase inhibitors. Organisms resistant other inhibitors were not...
Trends in antimicrobial resistance help inform infection control efforts. We examined trends for Enterobacteriaceae and Acinetobacter spp. from 2013 to 2017 hospitalized US patients. analyzed susceptibility of non-duplicate isolates patients (not limited hospital-acquired infections) the BD Insights Research Database. Resistance profiles interest were extended-spectrum beta-lactamase (ESBL)-producing, multidrug resistant (MDR), carbapenem-nonsusceptible (Carb-NS) phenotypes...
Study Objectives . To quantify the difference between glomerular filtration rates (GFRs) estimated by using Cockcroft‐Gault and Modification of Diet in Renal Disease (MDRD) equations, to determine whether dosing recommendations for four commonly prescribed antimicrobial agents are discordant when determined these equations. Design Prospective, observational study. Setting Tertiary‐care medical center. Patients Two hundred seven consecutive adults without normal renal function but not...
To determine antimicrobial nonsusceptibility rates for Enterobacteriaceae and Acinetobacter spp. in US hospitals.We analyzed susceptibilities of non-duplicate isolates reported 2017 from 375 hospitals the BD Insights Research Database. Logistic Poisson regression modeling methods were used to estimate proportions resistant per 1000 hospital admissions. National projections generated based on raking (weighting) methods.The nationwide inpatients an estimated 12.6%, 6.6%, 1.2% with...
The present study's objective was to evaluate serotonin toxicity with concomitant use of linezolid or comparators and serotonergic agents from 20 Phase III IV comparator-controlled clinical studies on treatment various Gram-positive infections. All reported adverse events were evaluated for using exact surrogate terms consistent Sternbach Criteria Hunter Serotonin Toxicity Criteria.Baseline demographics co-morbidities similar between comparator groups. No patients in either group have...
Abstract Background A diverse workforce provides opportunities for patients to be served by healthcare practitioners sharing a common race, ethnicity, culture, language, or disability. The Society of Infectious Disease Pharmacists (SIDP) aims increase engagement in an Antimicrobial Stewardship Certificate Program (ASCP) among clinicians identifying with underrepresented minoritized (URM) groups diversity, equity and inclusion; reduce antimicrobial resistance; improve outcomes. Methods SIDP...
Four experiments were conducted with 730 weanling pigs to determine the effects of soy protein concentrate (SPC) in diets for pigs. Experimental fed from d 0 14 postweaning and a common diet was 15 28 Exp. 1, 2, 3; experimental 7 4. In 4 included 1) 0% soybean meal (SBM) containing animal sources; 2) 40% SBM diet; or 28.55% SPC (replacing on total Lys basis) 3) source 4) 2. Pigs either had greater ADG ADFI (P <0.05) than source. 5 treatments 3, along 14.28% each used 1 half diet). From 28, x...
Study Objective. To evaluate the impact of a hospital‐acquired pneumonia (HAP) protocol on appropriateness empiric antibiotic therapy, deescalation, duration, patient mortality, and length stay. Design. Before‐ after‐study implementation. Setting. A 450‐bed, academic medical center. Patients. One hundred consecutive patients with proven or suspected HAP. Intervention. Implementation an HAP that was based 2005 American Thoracic Society‐Infectious Diseases Society America guidelines included...
Durlobactam (DUR; also known as ETX2514) is a novel β-lactamase inhibitor with broad activity against Ambler class A, C, and D β-lactamases. Addition of DUR to sulbactam (SUL) in vitro restores SUL clinical isolates Acinetobacter baumannii . The safety pharmacokinetics (PK) alone and/or imipenem-cilastatin (IMI-CIL) were evaluated healthy subjects. This was randomized, placebo-controlled study. In part subjects, including cohort elderly subjects (which received at 1 g), single ascending...
The goal of the Sexually Transmitted Infection Clinical Trial Group's Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry discuss current state research, gaps challenges research technology priorities new directions address continued emergence multidrug-resistant NG infections. Topics discussed at meeting, which will be focus this article, include AMR global surveillance initiatives, use whole genome...
Abstract Background Carbapenems are a frequent firstline therapy in complicated intra-abdominal infections (cIAIs). We examined the microbiology, epidemiology, and outcomes among patients hospitalized United States with culture-positive cIAIs context of their exposure to empiric carbapenem treatment (ECT). Methods performed multicenter retrospective cohort study Premier database ~180 hospitals, 2013–2017. Using an International Classification Diseases (ICD)-9/10-based algorithm, we...