A5010020881- Influenza Virus Research Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- Burkholderia infections and melioidosis
- interferon and immune responses
- Bacteriophages and microbial interactions
- Plant Pathogenic Bacteria Studies
- Genetics and Neurodevelopmental Disorders
- Insect symbiosis and bacterial influences
- Biosensors and Analytical Detection
- T-cell and B-cell Immunology
- Autism Spectrum Disorder Research
- Advanced biosensing and bioanalysis techniques
- Nematode management and characterization studies
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Nerve injury and regeneration
- Phytochemistry and biological activities of Ficus species
- Microbial infections and disease research
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Click Chemistry and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Brucella: diagnosis, epidemiology, treatment
University of Mississippi Medical Center
2022-2024
University of Mississippi
2022-2024
Jackson Memorial Hospital
2024
State Street (United States)
2022
University of Illinois Urbana-Champaign
2018-2020
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2017-2020
University of Cambridge
2018
Département Santé Animale
2017-2018
Mississippi State University
2013-2017
Paris-Est Sup
2017
Abstract Several lines of evidence point to a key role the hippocampus in Autism Spectrum Disorders (ASD). Altered hippocampal volume and deficits memory for person emotion related stimuli have been reported, along with enhanced ability declarative memories. Mouse models demonstrated critical social dysfunction, associated ASD, together decreased synaptic plasticity. Chondroitin sulfate proteoglycans (CSPGs), family extracellular matrix molecules, represent potential link between...
The mechanisms and consequences of defective interfering particle (DIP) formation during influenza virus infection remain poorly understood. development next-generation sequencing (NGS) technologies has made it possible to identify large numbers DIP-associated sequences, providing a powerful tool better understand their biological relevance. However, NGS approaches pose numerous technical challenges, including the precise identification mapping deletion junctions in presence frequent...
Gold nanostars, functionalized with thiolated DNA hairpins bearing a Raman-active fluorescent dye at the 3′ terminus, were engineered to identify and quantify RNA mutations in influenza A virus (IAV) genome employing surface enhanced Raman spectroscopy (SERS). The hairpin structure was designed selectively extend/fold absence/presence of viral targets, resulting fluorophore being brought away from or close gold nanostar surface, leading an "OFF-ON" switching SERS signal. Validation...
During viral infection, the numbers of virions infecting individual cells can vary significantly over time and space. The functional consequences this variation in cellular multiplicity infection (MOI) remain poorly understood. Here, we rigorously quantify phenotypic MOI during influenza A virus (IAV) a single round replication terms cell death rates, output kinetics, interferon antiviral effector gene transcription, superinfection potential. By statistically fitting mathematical models to...
The demonstrated link between the emergence of H3N2 variant (H3N2v) influenza A viruses (IAVs) and swine exposure at agricultural fairs has raised concerns about human health risk posed by IAV-infected swine. Understanding antigenic profiles IAVs circulating in pigs is critical to developing effective prevention control strategies. Here, 68 IAV isolates recovered from Ohio (2009 2011) were antigenically characterized. These compared with other H3 commercial swine, wild birds, canines, along...
ABSTRACT Influenza A viruses (IAVs) in swine can cause sporadic infections and pandemic outbreaks among humans, but how avian IAV emerges is still unclear. Unlike domestic swine, feral are free ranging have many opportunities for exposure through contacts with various habitats animals, including migratory waterfowl, a natural reservoir IAVs. During the period from 2010 to 2013, 8,239 serum samples were collected across 35 U.S. states tested against 45 contemporary antigenic variants of...
Influenza A viruses can infect a wide variety of animal species and, occasionally, humans. Infection occurs through the binding formed by viral surface glycoprotein hemagglutinin and certain types glycan receptors on host cell membranes. Studies have shown that α2,3-linked sialic acid motif (SA2,3Gal) in avian, equine, canine species; α2,6-linked (SA2,6Gal) humans; SA2,3Gal SA2,6Gal swine are responsible for corresponding tropisms. However, more detailed refined substructures determine...
Abstract The reniform nematode ( Rotylenchulus reniformis ) is a sedentary semi-endoparasitic species that pathogenic on many row crops, fruits, and vegetables. Here, the authors present draft genome assembly of R . using small- large-insert libraries sequenced Illumina GAIIx MiSeq platforms.
Abstract Xanthomonas citri pv. malvacearum is a major pathogen of cotton, Gossypium hirsutum L.. In this study we report the complete genome X. strain MSCT1 assembled from long read DNA sequencing technology. The first with coding regions for transcriptional activator-like effectors. addition functional and structural annotations are presented in that will provide foundation future pathogenesis studies MSCT1.
Burkholderia mallei is the etiological agent of glanders. Here, we present draft genome sequence strain 16-2438_BM#8 that was isolated from a mule found dead in Pernambuco, northeast Brazil. It first available genomic on American continent.
Abstract The mechanisms and consequences of defective interfering particle (DIP) formation during influenza virus infection remain poorly understood. development next generation sequencing (NGS) technologies has made it possible to identify large numbers DIP-associated sequences, providing a powerful tool better understand their biological relevance. However, NGS approaches pose numerous technical challenges including the precise identification mapping deletion junctions in presence frequent...
ABSTRACT During viral infection, the numbers of virions infecting individual cells can vary significantly over time and space. The functional consequences this variation in cellular multiplicity infection (MOI) remain poorly understood. Here, we rigorously quantify phenotypic MOI during influenza A virus (IAV) a single round replication terms cell death rates, output kinetics, interferon antiviral effector gene transcription, superinfection potential. By statistically fitting mathematical...
A large population of genetically and antigenically diverse influenza viruses (IAVs) are circulating among the swine population, playing an important role in ecology. Swine IAVs not only cause outbreaks but also can be transmitted to humans, causing sporadic infections even pandemic outbreaks. Antigenic characterizations key understanding natural history these selecting strains for effective vaccines. However, generally spread rapidly swine, conventional methods antigenic characterization...
There is a growing interest in the detection of subtle changes cardiovascular physiology response to viral infection develop better disease surveillance strategies. This not only important for earlier diagnosis and prognosis symptomatic carriers but also useful diagnose asymptomatic virus. Previous studies provide strong evidence an association between inflammatory biomarker levels both blood pressure (BP) heart rate (HR) during infection. The identification novel biomarkers event could...
Early detection of influenza virus infection can potentially reduce risk morbidity, mortality, and transmission through earlier intervention strategies. Although seasonal is a localized respiratory viral infection, changes in cardiovascular physiology inflammatory biomarkers have been previously observed by our group mice during infection. Distinguishing patterns among common blood panels, including complete count, basic metabolic, comprehensive coagulation panel, c-reactive protein, could...
For better infectious disease surveillance, there is growing interest in the detection of subtle changes cardiovascular physiology response to viral infection. This not only important for earlier diagnosis and prognosis symptomatic carriers, but also useful diagnose asymptomatic carriers virus. In our previous study, we found induced A/Puerto Rico/8/34 (PR8) influenza infections female male C57BL/6J mice. Reduction activity, blood pressure (BP) heart rate (HR) females was observed...