A5095947228- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- Neuroinflammation and Neurodegeneration Mechanisms
- Aquaculture disease management and microbiota
- Neurobiology and Insect Physiology Research
- Antimicrobial Peptides and Activities
University of Birmingham
2024-2025
Fungi can intervene in hosts’ brain function. In humans, they drive neuroinflammation, neurodegenerative diseases and psychiatric disorders. However, how fungi alter the host is unknown. The mechanism underlying innate immunity to well-known universally conserved downstream of shared Toll/TLR receptors, which via adaptor MyD88 transcription factor Dif/NFκB, induce expression antimicrobial peptides (AMPs). brain, Toll-1 could also an alternative pathway Sarm, causes cell death instead. Sarm...
Abstract Fungi evolve within the host, ensuring their own nutrition and reproduction, at expense of host health. They intervene in hosts’ brain function, to alter behaviour induce neurodegeneration. In humans, fungal infections are emerging as drivers neuroinflammation, neurodegenerative diseases psychiatric disorders. However, how fungi is unknown. trigger an innate immune response mediated by Toll-1/TLR receptor, adaptor MyD88 transcription factor Dif/NFκB, that expression antimicrobial...