A5108017512- Neurobiology and Insect Physiology Research
- Animal Behavior and Reproduction
- Receptor Mechanisms and Signaling
- Invertebrate Immune Response Mechanisms
- Nerve injury and regeneration
- Insect and Arachnid Ecology and Behavior
- Insect Utilization and Effects
- Insect symbiosis and bacterial influences
- Neuroendocrine regulation and behavior
- Insect and Pesticide Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Antimicrobial Peptides and Activities
- Neuroscience and Neuropharmacology Research
- Aquaculture disease management and microbiota
- Fuel Cells and Related Materials
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
University of Birmingham
2023-2025
University of Manchester
2025
The dynamic regulation of RNA metabolism plays a crucial part in cellular function, with emerging evidence suggesting an important role for modifications this process. This study explores the relationship between splicing and TET dioxygenase activity, shedding light on hm5C (RNA 5-hydroxymethylcytosine), proteins, metabolism. Integrating data from mass spectrometry, AlphaFold structural modeling, microscopic analysis, different functional assays including vitro splicing, proteins were found...
Fungi can intervene in hosts’ brain function. In humans, they drive neuroinflammation, neurodegenerative diseases and psychiatric disorders. However, how fungi alter the host is unknown. The mechanism underlying innate immunity to well-known universally conserved downstream of shared Toll/TLR receptors, which via adaptor MyD88 transcription factor Dif/NFκB, induce expression antimicrobial peptides (AMPs). brain, Toll-1 could also an alternative pathway Sarm, causes cell death instead. Sarm...
Sex-peptide (SP) transferred during mating induces female post-mating responses including refractoriness to re-mate and increased oviposition in Drosophila . Yet, where SP target neurons reside, remained uncertain. Here we show that expression of membrane-tethered (mSP) the head or trunk either reduces receptivity increases oviposition, respectively. Using fragments from large regulatory regions Sex Peptide Receptor , fruitless doublesex genes together with intersectional mSP, identified...
Experience shapes the brain as neural circuits can be modified by stimulation or lack of it. The molecular mechanisms underlying structural circuit plasticity and how modifies behaviour are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns value to stimuli, it also controls behaviour, including locomotion, learning, memory. In Drosophila , Toll receptors ideally placed translate into change. Toll-6 is expressed in dopaminergic neurons (DANs), raising...
Experience shapes the brain as neural circuits can be modified by stimulation or lack of it. The molecular mechanisms underlying structural circuit plasticity and how modifies behaviour are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns value to stimuli, it also controls behaviour, including locomotion, learning, memory. In Drosophila , Toll receptors ideally placed translate into change. Toll-6 is expressed in dopaminergic neurons (DANs), raising...
Abstract Sex-peptide (SP) transferred during mating induces female post-mating responses including refractoriness to re-mate and increased oviposition in Drosophila . Yet, where SP target neurons reside, remained uncertain. Here we show that expression of membrane-tethered (mSP) the head or trunk either reduces receptivity increases oviposition, respectively. Using fragments from large regulatory regions Sex Peptide Receptor , fruitless doublesex genes together with intersectional mSP,...
Abstract Fungi evolve within the host, ensuring their own nutrition and reproduction, at expense of host health. They intervene in hosts’ brain function, to alter behaviour induce neurodegeneration. In humans, fungal infections are emerging as drivers neuroinflammation, neurodegenerative diseases psychiatric disorders. However, how fungi is unknown. trigger an innate immune response mediated by Toll-1/TLR receptor, adaptor MyD88 transcription factor Dif/NFκB, that expression antimicrobial...
Sex-peptide (SP) transferred during mating induces female post-mating responses including refractoriness to re-mate and increased oviposition in Drosophila . Yet, where SP target neurons reside, remained uncertain. Here we show that expression of membrane-tethered (mSP) the head or trunk either reduces receptivity increases oviposition, respectively. Using fragments from large regulatory regions Sex Peptide Receptor , fruitless doublesex genes together with intersectional mSP, identified...
Experience shapes the brain, as neural circuits can be modified by stimulation or lack of it. The molecular mechanisms underlying structural circuit plasticity and how modifies behaviour, are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns value to stimuli, it also controls including locomotion, learning memory. In Drosophila , Toll receptors ideally placed translate into brain change. Toll-6 is expressed in dopaminergic neurons (DANs), raising...
Experience shapes the brain, as neural circuits can be modified by stimulation or lack of it. The molecular mechanisms underlying structural circuit plasticity and how modifies behaviour, are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns value to stimuli, it also controls including locomotion, learning memory. In Drosophila , Toll receptors ideally placed translate into brain change. Toll-6 is expressed in dopaminergic neurons (DANs), raising...
Experience shapes the brain, as neural circuits can be modified by stimulation or lack of it. The molecular mechanisms underlying structural circuit plasticity and how modifies behaviour, are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns value to stimuli, it also controls including locomotion, learning memory. In Drosophila, Toll receptors ideally placed translate into brain change. Toll-6 is expressed in dopaminergic neurons (DANs), raising...