A5057854007- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Parkinson's Disease Mechanisms and Treatments
- Pain Management and Treatment
- Genetic Neurodegenerative Diseases
- Epilepsy research and treatment
- Musculoskeletal pain and rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Trigeminal Neuralgia and Treatments
- Pain Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Anesthesia and Pain Management
- Advanced MRI Techniques and Applications
- Augmented Reality Applications
- Spine and Intervertebral Disc Pathology
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
University of Utah
2022-2025
Duke University
2015-2023
Harvard University Press
2023
Duke University Hospital
2016-2022
Duke Medical Center
2016-2022
Wasatch Molecular (United States)
2022
Oxford University Press (United Kingdom)
2021
Neurological Surgery
2021
Yale University
2018
National Institute of Neurological Disorders and Stroke
2012-2015
The prognosis of elderly patients with glioblastoma (GBM) is universally poor. Currently, few studies have examined postoperative outcomes and the effects various modern therapies such as bevacizumab on survival in this patient population. In study, authors evaluated factors overall a cohort newly diagnosed GBM.A retrospective review was performed (≥ 65 years old) GBM treated between 2004 2010. Various characteristics were univariate multivariate stepwise models to examine their complication...
Patients suffering from debilitating neurodegenerative diseases often lose the ability to communicate, detrimentally affecting their quality of life. One solution restore communication is decode signals directly brain enable neural speech prostheses. However, decoding has been limited by coarse recordings which inadequately capture rich spatio-temporal structure human signals. To resolve this limitation, we performed high-resolution, micro-electrocorticographic (µECoG) during intra-operative...
Glioblastoma (GBM) is the most common and deadly primary brain tumor in adults. Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), can attenuate tumor-associated edema improve patient symptoms but based on magnetic resonance imaging, associated with non-enhancing progression possibly gliosarcoma differentiation. To gain insight into these findings, we investigated role of hypoxia epithelial-mesenchymal transition (EMT)-associated proteins GBM....
External ventricular drain (EVD) is a common, yet challenging neurosurgical procedure of placing catheter into the brain system that requires prolonged training for surgeons to improve placement accuracy. In this paper, we introduce NeuroLens, an Augmented Reality (AR) provides neurosurgeons with guidance aides them in completing EVD placement. NeuroLens builds on prior work AR-assisted present registered hologram patient's ventricles surgeons, and uniquely incorporates catheter's...
Gaucher disease is caused by mutations of the GBA gene that encodes lysosomal enzyme glucocerebrosidase (GCase). often result in protein misfolding and premature degradation, but usually exert less effect on catalytic activity. In this study, we identified molecular mechanism which histone deacetylase inhibitors increase quantity activity GCase. Specifically, these limit deacetylation heat shock 90, resulting recognition mutant peptide GCase degradation. These findings provide insight into a...
Objective.Brain functions such as perception, motor control, learning, and memory arise from the coordinated activity of neuronal assemblies distributed across multiple brain regions. While major progress has been made in understanding function individual neurons, circuit interactions remain poorly understood. A fundamental obstacle to deciphering is limited availability research tools observe manipulate large, populations humans. Here we describe development, validation, dissemination...
Abstract BACKGROUND Opioid misuse in the USA is an epidemic. Utilization of neuromodulation for refractory chronic pain may reduce opioid-related morbidity and mortality, associated economic costs. OBJECTIVE To assess impact spinal cord stimulation (SCS) on opioid dose reduction. METHODS The IBM MarketScan® database was retrospectively queried all US patients with a diagnosis undergoing SCS between 2010 2015. usage before after procedure quantified as morphine milligram equivalents (MME)....
Conventional atlases of the human brainstem are limited by inflexible, sparsely-sampled, two-dimensional nature histology, or low spatial resolution conventional magnetic resonance imaging (MRI). Postmortem high-resolution MRI circumvents challenges associated with both modalities. A single specimen extending from rostral diencephalon through caudal medulla was prepared for after brain removed a 65-year-old male within 24 h death. The formalin-fixed two weeks, then rehydrated and placed in...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and nonmotor symptoms. Although the basal ganglia traditionally primary brain region implicated in this process, limited view ignores roles of cortex cerebellum that are networked with to support cognitive functions. In particular, recent research has highlighted dysfunction supplementary complex (SMC) patients PD. Using PubMed Google Scholar search engines, we identified articles using keywords pertaining...
External ventricular drain (EVD) is a common, yet challenging neurosurgical procedure of placing catheter into the brain system that requires prolonged training for surgeons to improve placement accuracy. In this paper, we introduce NeuroLens, an Augmented Reality (AR) provides neurosurgeons with guidance aides them in completing EVD placement. NeuroLens builds on prior work AR-assisted present registered hologram patient's ventricles surgeons, and uniquely incorporates catheter's...
Abstract Objective Effective surgical treatment of drug‐resistant epilepsy depends on accurate localization the epileptogenic zone (EZ). High‐frequency oscillations (HFOs) are potential biomarkers EZ. Previous research has shown that HFOs often occur within submillimeter areas brain tissue and coarse spatial sampling clinical intracranial electrode arrays may limit capture HFO activity. In this study, we sought to characterize microscale activity captured thin, flexible...
OBJECTIVE Deep brain stimulation (DBS) is a well-established treatment for Parkinson’s disease (PD) and essential tremor (ET). Although the prevalence of PD ET can vary by sex race, little known about accessibility neurosurgical treatments these conditions. In this nationwide study, authors aimed to characterize trends in use DBS identify disparities diseases based on ethnic, racial, sex, insurance, income, hospital, geographic factors. METHODS Using dates January 1, 2012, December 31, 2019,...
Unplanned hospital readmissions contribute significantly to soaring national healthcare expenditures. To alleviate this burden, Centers for Medicare and Medicaid Services implemented initiatives penalize hospitals unplanned 30-d readmissions. There is a paucity of data identifying patient risk factors independently associated with 30- 90-d readmissions.To investigate similarities in following elective lumbar spine surgery.The National Readmission Database (NRD) was queried identify patients...
One-third of epilepsy patients suffer from medication-resistant seizures. While surgery to remove epileptogenic tissue helps some patients, 30-70% continue experience seizures following resection. Surgical outcomes may be improved with more accurate localization tissue. We have previously developed novel thin-film, subdural electrode arrays hundreds microelectrodes over a 100-1000 mm2 area enable high-resolution mapping neural activity. Here, we used these high-density study microscale...
Abstract Objective Delay in referral for epilepsy surgery of patients with drug‐resistant (DRE) is associated decreased quality life, worse surgical outcomes, and increased risk sudden unexplained death (SUDEP). Understanding the potential causes delays treatment crucial optimizing process. We evaluated intervals, demographics, clinical characteristics referred evaluation at our level 4 center U.S. Intermountain West. Methods retrospectively reviewed records who underwent DRE between 2012...
Lesion-symptom correlations shaped the early understanding of cortical localization. The classic Broca-Wernicke model speech and language organization underwent a paradigm shift in large part due to advances brain mapping techniques. This initially started by demonstrating that cortex was excitable. Later, advancements neuroanesthesia led awake surgery for epilepsy focus tumor resection, providing neurosurgeons with means studying subcortical pathways understand neural architecture obtain...
Seizure termination has been linked to spreading depolarizations (SDs) in experimental epilepsy models, and SDs have recently suggested protect against seizures. The precise mechanism, however, remains unclear. Additionally, the co-occurrence of with human seizures debated. In this study, we found that are a prominent feature following ictal events both clinical recordings (n=20 from 7 patients) using direct-current amplifiers 0 Mg2+ model ictogenesis rodent brain slices (n=17)....