A5060130824- Cancer and Skin Lesions
- Neuroendocrine Tumor Research Advances
- Head and Neck Cancer Studies
- Gastrointestinal disorders and treatments
- Adrenal and Paraganglionic Tumors
- Nonmelanoma Skin Cancer Studies
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Cell Image Analysis Techniques
- AI in cancer detection
- Salivary Gland Tumors Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cutaneous Melanoma Detection and Management
- Organ and Tissue Transplantation Research
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Medical Image Segmentation Techniques
- Monoclonal and Polyclonal Antibodies Research
- PI3K/AKT/mTOR signaling in cancer
- Soft tissue tumor case studies
- Cutaneous lymphoproliferative disorders research
Aristotle University of Thessaloniki
2014-2024
AHEPA University Hospital
2011-2024
Creative Commons
2022
Hellenic Cooperative Oncology Group
2007-2018
Hôpital Edouard Herriot
2013
Papageorgiou General Hospital
2010
Interbalkan Medical Center
2008
Harvard University
2007
Dana-Farber Cancer Institute
2007
Thomas Jefferson University
1988
The combination of gemcitabine and gefitinib was evaluated in advanced pancreatic cancer. Totally, 53 patients were treated with a 7 week cycle (1,000 mg/m2 given weekly) followed by six 4 cycles on days 1, 8 15. Gefitinib 250 mg administered daily. Responses seen 6, stabilization the disease 12 patients. main toxicity myelotoxicity (92%). 6-month progression-free survival (PFS) 30%. Median PFS 4.1 months median 7.3 1 year rate 27%. above demonstrated promising activity
BackgroundThe clinical relevance of mismatch repair (MMR) status in patients with nonmetastatic cancer across tumour types remains unclear. Our goal was to investigate the prognostic role MMR deficiency stage I-III colorectal and endometrial cancer.MethodsPatients tissue available for analysis were identified through Hellenic Cooperative Oncology Group (HeCOG)'s repository. Patients had been referred Departments Medical affiliated HeCOG. protein expression evaluated by immunohistochemistry....
The evaluation of fluorescent in situ hybridization (FISH) images is one the most widely used methods to determine Her-2/neu status breast samples, a valuable prognostic indicator. Conventional difficult task since it involves manual counting dots multiple images. In this paper, we present multistage algorithm for automated classification FISH from carcinomas. focuses not only on detection per image, but also combining results taken slice overall case classification. includes mainly two...
Solitary fibrous tumor (SFT) is a mesenchymal typically located in the pleura, but can also be found as an asymptomatic mass other areas, including liver, peritoneum, kidney and salivary glands. However, SFT rarely locates pancreas. We present such case of pancreatic SFT, along with review all reported cases. A 55-year-old man was treated surgically for after rigorous preoperative control. Histologic examination resected specimen showed characteristics SFT. As only 15 cases have been so far,...
Vascularized composite tissue allografts (VCA) can undergo rejection, manifesting pathologically with skin changes that form the basis of Banff 2007 classification VCA rejection.We have followed 10 human recipients (7 hand allografts, 3 face allografts) for pathological signs rejection. All them developed episodes acute Two patients presented in some their biopsies an as yet unreported finding VCA, consisting capillary thromboses (CT) upper dermis.Capillary thrombosis was associated other...
Concomitant administration of radiotherapy with cisplatin or cetuximab appear to be the treatment choice for patients locally advanced head and neck cancer. In present retrospective analysis, we investigated predictive role several biomarkers in an unselected cohort treated concomitant radiotherapy, weekly cisplatin, (CCRT). We identified 37 this approach, which 13 (35%) achieved a complete response 10 (27%) partial response. Severe side effects were mainly leucopenia, dysphagia, rash,...
Objective: Although appendicitis is one of the most common causes emergency surgery, parasites are rarely found associated with inflammation appendix.The aim this study to establish prevalence Enterobius vermicularis in surgically removed appendices, as well determine its possible role pathogenesis appendicitis.Methods: A retrospective analysis all appendices during last 20 years at a tertiary university hospital.Appendices course another intra-abdominal procedure were excluded from...
Since scarce data exist on the pathogenesis of nasopharyngeal carcinoma in Caucasian patients, we attempted to elucidate responsible molecular pathways this patient population.Formalin-fixed paraffin-embedded tumor tissue samples from 107 diagnosed with locally-advanced and treated chemotherapy or chemo-radiotherapy, were analyzed by immunohistochemistry for expression following proteins: E-cadherin, P-cadherin, Fascin-1, Cyclin D1, COX-2, EGFR, VEGF-A, VEGF-C, VEGFR-2, VEGFR-3, ERCC1, p53,...
A mesenteric chylous cyst is defined as a occurring in the mesentery of gastrointestinal tract anywhere from duodenum to rectum and diagnosed most often during fifth decade life. In our case report, we describe 38-year-old Greek woman who presented at Emergency Department complaining abdominal pain without any other symptoms. Her medical family histories were clear she had never interventions. During an imaging examination with ultrasound her abdomen, anechoic lesion upper left abdomen was...
A prospective interventional pilot study was performed to estimate the effect of ranibizumab injection on clinical and histological picture primary pterygium.Five patients with pterygia received a single subconjunctival (0.3 mg), whereas 5 nontreated served as controls. The treated were surgically removed 3 days, 1 week, 2 weeks, month, months after injection, respectively. Digital photographs taken immediately before week after, day operation.Ranibizumab well tolerated by all patients, no...
EGFR has been associated with unfavourable prognosis in patients triple-negative breast carcinomas, although little is known about activation these tumours. In a series of carcinomas (archived formalin fixed tumours, n=100), we investigated phosphorylation status at Tyr992 (pEGFR-Y992) and Tyr1068 (pEGFR-Y1068) by immunohistochemistry, along protein expression (extracellular domain), gene amplification (fluorescent situ hybridization) conventional clinicopathologic parameters. was present...
Abstract Background The shift towards an earlier diagnosis of breast cancer (BC) highlights the need for biomarkers that would identify patients at risk relapse and metastatic spread indicate potential value additional treatment strategies. Osteopontin (OPN) is a matricellular protein has been suggested to be biomarker in BC. In present study, we used archived BC patient samples assess clinical utility OPN. Methods Formalin-fixed paraffin-embedded tumor tissue from 975 were collected two...
Abstract Background Coexistence of adenocarcinoma and mantle cell lymphoma in the same or different anatomical sites is extremely rare. We present a case incidental discovery primary lung involving pleura, during an axillary thoracotomy performed for benign condition. Case presentation A 73-year old male underwent bullectomy apical pleurectomy persistent pneumothorax. bulla apex was resected en bloc with scar-like lesion lung, which located proximity origin, by wide wedge resection....