A5079281552- Andrographolide Research and Applications
- Synthesis and biological activity
- Biochemical and Structural Characterization
- Transgenic Plants and Applications
- Glycosylation and Glycoproteins Research
- Inflammatory Bowel Disease
- Quinazolinone synthesis and applications
- Chronic Myeloid Leukemia Treatments
- Microwave-Assisted Synthesis and Applications
- Inflammation biomarkers and pathways
- Phytochemical compounds biological activities
- Fungal Plant Pathogen Control
- Bioactive Compounds and Antitumor Agents
- Crystallization and Solubility Studies
- Virology and Viral Diseases
- Traditional Chinese Medicine Analysis
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Metabolism and Genetic Disorders
- Malaria Research and Control
- dental development and anomalies
- Immune cells in cancer
- Insect symbiosis and bacterial influences
- Parasitic Diseases Research and Treatment
- Cholesterol and Lipid Metabolism
Nanjing Tech University
2014-2024
Taizhou Vocational and Technical College
2019-2024
People’s Hospital of Rizhao
2022
AGS-30, a new andrographolide derivative, showed significant anticancer and anti-angiogenic characteristics. However, its role in controlling macrophage polarization tumor immune response is unknown. Thus, the main goals of this study are to investigate how AGS-30 regulates it suppresses breast cancer metastasis. inhibited IL-4 IL-13-induced RAW 264.7 THP-1 macrophages into M2-like phenotype. did not affect LPS IFN-γ-induced M1-like macrophages. reduced mRNA expressions CD206, Arg-1, Fizz-1,...
Alzheimer's disease (AD) is a neurodegenerative characterized by progressive deterioration of memory and cognition. Mild cognitive impairment (MCI) has been implicated as prodromal phase AD. Although abnormal functional connectivity (FC) demonstrated in AD MCI, the clinical differentiation AD, normal aging remains difficult, distinction between MCI especially problematic. We hypothesized that FC hippocampus other brain structures altered measurement could have diagnostic utility for...
Some 14β-phenoxy substituted derivatives of andrographolide were designed, synthesized and investigated as FXR novel antagonists.
Rare earth metal (RE = La, Pr, Nd, Y)-doped CoCeOx catalysts were prepared and evaluated for eliminating chlorobenzene (CB). Characterization results showed that the doped RE simultaneously acts as a structural electronic assistant, which changes coordination environment of Ce ions enhances interaction between Co species, thus improving catalytic performance chlorine resistance CoCeOx. Besides, dynamic "redox gears" based on Co/Ce redox couples proposed. doping was found to promote movement...
Antibacterials (which restore gut flora balance) and immunosuppressants correct immune defects) are two important effective therapeutic agents for the treatment of inflammatory bowel disease (IBD) in clinical use today. Since structural skeleton andrographolide, isolated from Andrographis paniculata, has become known as a natural antibiotic with anti-inflammation heat-clearing detoxifying properties, 14-aryloxy andrographolide derivatives have been designed, synthesized, tested their...
Acetal and ketal andrographolide derivatives presented differing anti-angiogenic activities when applied to<italic>in vitro</italic>and<italic>in vivo</italic>models, leading to different inhibitory outcomes.
Abstract C 31 H 37 NO 7 , monoclinic, P 2 1 (no. 4), a = 8.1269(1) Å, b 11.0527(1) c 16.3586(2) β 97.973(1)°, V 1455.19(3) Å 3 Z 2, R gt ( F ) 0.0467, wR ref 0.1308, T 293(2) K.
Currently, it still remains a difficult problem to treat apical insufficiency of young permanent teeth resulted from pulp necrosis or periapical periodontitis. Previous studies have demonstrated that the treatment revascularization using stem cells papilla (SCAPs) results in increased root length and thickness traumatized immature necrotic pulp. In this study, we investigated role 1,25-dihydroxyvitamin D3 regulating adhesion, spreading, proliferation, osteogenic differentiation SCAP, laying...
The rearrangement activity of benzyl aryl ether catalyzed by polyphosphoric acid (PPA) was systematically investigated.Optimal structural tuning substitutions electron withdrawing group (EWG) and donating (EDG) at phenolic moiety or benefits the regio-selectivity obeyed substitution directing rule aromatic ring.This readily available method is practical interest for benzylation diverse phenols.