A5023484862- Economic Growth and Productivity
- Labor market dynamics and wage inequality
- Economic Theory and Policy
- Economic theories and models
- Fiscal Policy and Economic Growth
- RNA and protein synthesis mechanisms
- Magnetic Properties of Alloys
- Cholesterol and Lipid Metabolism
- Advanced Operator Algebra Research
- Income, Poverty, and Inequality
- Advanced Topics in Algebra
- RNA Research and Splicing
- Metal Alloys Wear and Properties
- Mitochondrial Function and Pathology
- Powder Metallurgy Techniques and Materials
- Magnetic and transport properties of perovskites and related materials
- Conducting polymers and applications
- Semiconductor Lasers and Optical Devices
- Genetic and Kidney Cyst Diseases
- ATP Synthase and ATPases Research
- Chemical Synthesis and Reactions
- Firm Innovation and Growth
- Neuroscience and Neuropharmacology Research
- Catalytic Cross-Coupling Reactions
- Multiferroics and related materials
Nippon Chemiphar (Japan)
2010-2025
Kyushu University
2025
Johns Hopkins Medicine
2016-2024
Johns Hopkins University
2016-2024
Kyoto University
2014-2024
Nishijin Hospital
2019-2024
Nagoya University
2024
Osaka Metropolitan University
2022-2023
Osaka University of Economics
2015-2023
Dynamic Systems (United States)
2023
This article explains deviations from formal expectations regarding choice behavior in settings where economic rationality (i.e., own payoff maximization) dictates either cooperating (full contribution) or free riding (no the provision of public goods via voluntary contribution mechanism. The authors find that difference between full and observed level is greater than equal to corresponding when best strategy. surprising result interpreted as “spiteful” subjects whose first priority not...
Characterizing the protein constituents of a specific organelle and neighbors interest (POI) is essential for understanding function state networks associated with POI. Proximity labeling (PL) has emerged as promising technology efficient spatial proteomics. Nevertheless, most enzymes adopted PL still have limitations: APEX requires cytotoxic H2O2 activation thus poor in biocompatibility vivo application, BioID shows insufficient kinetics, TurboID suffers from high background biotinylation....
Cilia are structurally and functionally diverse organelles, whose malfunction leads to ciliopathies. While recent studies have uncovered common ciliary transport mechanisms, limited information is available on the proteome of cilia, particularly that sensory subtypes, which could provide insight into their functional developmental diversities. In present study, we performed proteomic analysis unique, multiple 9+0 cilia in choroid plexus epithelial cells (CPECs). The juvenile swine CPEC...
Pharmacological activation of G protein-coupled receptor 119 (GPR119) produces pleiotropic beneficial effects, including the promotion insulin secretion from pancreatic β-cells, enhancement glucagon-like peptide (GLP)-1 intestinal L cells, glucose-dependent secretion, and food intake body weight gain suppression. Thus, GPR119 has attracted attention as a promising new target for type 2 diabetes mellitus (T2DM) treatment. Here, we identified small agonist, NCP-322. This compound showed potent...
We compared the mechanisms of apolipoprotein E- (apoE-) and antioxidant- (AO-) mediated inhibition beta-amyloid fibril (fA beta) formation in vitro, based on a nucleation-dependent polymerization model using fluorescence spectroscopy with thioflavin T. first applied kinetic plot to transform sigmoidal time-course curve fA beta from freshly prepared amyloid beta-peptides (A into straight line. Mathematical treatment this demonstrated that above-described is logistic provided us parameter...
M. Kaneko and H. Nakamura, J. Chem. Soc., Commun., 1985, 346 DOI: 10.1039/C39850000346
Inositol 1,4,5-trisphosphate receptor type1 (IP3R1) plays an important role in neuronal functions; however, the lateral diffusion of IP3R1 on endoplasmic reticulum membrane and its regulation living neurons remain unknown. We expressed green fluorescent protein-tagged cultured rat hippocampal observed by fluorescence recovery after photobleaching technique. showed with effective constant approximately 0.3 microm2/s. Depletion actin filaments increased IP3R1, suggesting that is regulated...
The diffusion of materials from systemic circulation to the central nervous system (CNS) is restricted by blood-brain barrier (BBB) and blood-cerebrospinal fluid (BCSFB). Choroid plexus epithelial cells (CPECs) brain ventricles constitute BCSFB regulate infiltration plasma proteins as well immune into interstitium CNS. function altered in pathologic conditions. However, regulatory mechanism not fully understood. Here, we investigated transient receptor potential vanilloid 4 (TRPV4), a...
Cilia have crucial roles in various developmental and physiological events. Previously, we reported that choroid plexus epithelial cells (CPECs) multiple, nonmotile 9+0 cilia, but the cilia exhibit transient motility with variable axonemal arrangements neonatal period. These features make these unique, as they do not fit to traditional categories of primary or motile their remain elusive. To address this issue, studied ciliary on CPECs through development, particular interest embryonic In...
9-Methyl-7-bromoeudistomin D (MBED), a derivative of eudistomin isolated from marine tunicate, induced Ca++ release the heavy fraction fragmented sarcoplasmic reticulum (HSR) in same way as that caffeine, followed by spontaneous reuptake electrode experiment. The rate 45Ca++ efflux HSR vesicles was accelerated markedly MBED or caffeine concentration-dependent manner. 50% effective concentrations and were approximately 1 microM mM, respectively, indicating is 1000 times more potent than HSR....
To establish a convenient method for decontaminating bioclean rooms, the effect of ozone at 80 mg/m3 72 h was compared with formaldehyde vaporization an initial concentration 150 gradual decrease to 20 during h. Ozone found be inferior in activity. When room decontaminated twice ozone, mean colony count per 10 cm2 decreased about same level as when used. had strong caustic upon rubber materials. Despite these disadvantages, decontamination demonstrated superior because convenience,...
Sarco/endoplasmic reticulum (SR/ER) Ca2+-ATPase (SERCA) is an intracellular Ca2+ pump localized on the SR/ER membrane. The role of SERCA in refilling stores pivotal for maintaining homeostasis, and disturbed activity causes many disease phenotypes, including heart failure, diabetes, cancer, Alzheimer disease. Although has been described using a simple enzyme equation, dynamics living cells still unknown. To monitor cells, we constructed enhanced CFP (ECFP)- FlAsH-tagged SERCA2a, designated...
Purpose To compare the calculation errors of intraocular lens (IOL) power in patients with posterior keratoconus and to determine which corneal refractive is suitable for these calculations. Setting Chukyo Hospital, Nagoya, Japan. Design Retrospective case series. Methods This retrospective chart review was performed identify eyes diagnosed using anterior segment optical coherence tomography (AS-OCT). The keratometry (K) values were measured an autokeratometer partial interferometry (PCI)...
We show that if two aperiodic automorphisms of a separable nuclear unital purely infinite simple $C^{\ast}$-algebra are asymptotically unitarily equivalent, then they outer conjugate with respect to an automorphism which is isotopic the identity automorphism. Thus, by Kirchberg and Phillips, have same KK-class only in
Our purpose was to investigate the MR features of lacrimal glands in patients with Sjögren's syndrome. Using imaging, we examined 58 29 women syndrome and 150 75 female control subjects. The ranged age from 21 76 years, subjects 0 78 years. We analyzed thicknesses internal signal intensity patterns compared results flow rates using Schirmer's test. On basis profile normal age-related decreases gland thickness that obtained our subjects, categorized as hypertrophic (7.8 +/- 0.8 mm),...
${}^{59}\mathrm{Co}$ nuclear magnetic resonance (NMR) studies have been made to clarify the spin-state and local properties of ${\mathrm{Nd}}_{1\ensuremath{-}x}{\mathrm{Sr}}_{x}{\mathrm{CoO}}_{3}$ $(0<~x<~0.5).$ Three different types Co NMR spectra are obtained. The parent ${\mathrm{NdCoO}}_{3}$ exhibits only one type a line associated with low spin state ${\mathrm{Co}}^{3+}$ ion. temperature dependence indicates gradual transition from $(T=0\mathrm{K})$ intermediate state. A similar...
This paper presents a model of technical change that combines two lines research together. It is task based model, in which automation turns labor tasks to mechanized ones, and there also continuous addition new tasks, as the expanding variety literature. We impose three simple restrictions on model. The first all are adopted. second automations adopted third share does not converge zero long run. show these imply unemployment due expected over time.