A5064512852- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Vestibular and auditory disorders
- Sodium Intake and Health
- Memory and Neural Mechanisms
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Autism Spectrum Disorder Research
- Hearing, Cochlea, Tinnitus, Genetics
- Child and Adolescent Psychosocial and Emotional Development
- Immune cells in cancer
- Amino Acid Enzymes and Metabolism
- Electrolyte and hormonal disorders
- Neurogenesis and neuroplasticity mechanisms
- Sleep and Wakefulness Research
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Human-Animal Interaction Studies
McMaster University
2021-2025
University of California, Los Angeles
2015-2020
McGill University Health Centre
2012-2016
Montreal General Hospital
2012-2016
McGill University
2014
The mechanisms by which dietary salt promotes hypertension are unknown. Previous work established that plasma [Na+] and osmolality rise in proportion with intake thus promote release of vasopressin (VP) from the neurohypophysis. Although high levels circulating VP can increase blood pressure, this effect is normally prevented a potent GABAergic inhibition neurons aortic baroreceptors. Here we show chronic impairs baroreceptor rat through brain-derived neurotrophic factor (BDNF)-dependent...
Cells can release the free amino acid taurine through volume-regulated anion channels (VRACs), and it has been hypothesized that released from glial cells is capable of inhibiting action potential (AP) firing by activating neuronal glycine receptors (GlyRs) (Hussy et al., 1997). Although an inhibitory GlyR tone widely observed in brain, remains unknown whether this specifically reflects gliotransmission because most neurons also express VRACs other endogenous molecules activate GlyRs. We...
Neuron-glia interactions play a central role in regulating synaptic transmission and neuronal excitability. Structural plasticity of astrocytes is associated with numerous physiological pathological conditions, however, the mechanism underlying this process remains unknown. To examine basis for structural astrocyte plasticity, we used classic example loss astrocytic processes that takes place hypothalamic magnocellular system during chronic high-salt intake. We discovered diet triggers local...
Activation of hypothalamic paraventricular oxytocin (OXT PVN ) neurons by social or stress stimuli triggers OXT release to respectively promote investigation buffer adverse effects stress. Astrocytes, a type glial cells, can bidirectionally interact with participate in local activity regulation within the nucleus (PVN). It remains unknown whether contextual factors related stimuli, as well biological such sex, influence neuronal astrocyte and/or their interactions. To address this question,...
Abstract Magnocellular neurosecretory cells (MNCs) are intrinsically osmosensitive and can be activated by increases in blood osmolality, triggering the release of antidiuretic hormone vasopressin (VP) to promote water retention. Hence, activity magnocellular VP neurons is one key elements contributing regulation body fluid homeostasis healthy organisms. Chronic exposure high dietary salt leads excessive activation neurons, thereby elevating levels circulating VP, which cause pressure...
Magnocellular vasopressin (VP) neurones are activated by increases in blood osmolality, leading to the secretion of VP into circulation promote water retention kidney, thus constituting a key mechanism for regulation body fluid homeostasis. However, chronic high salt intake can lead excessive activation and increased circulating levels VP, contributing an elevation pressure. Multiple extrinsic factors, such as synaptic inputs glial cells, modulate activity neurones. Moreover, magnocellular...
In the ventral glial limitans (VGL) of supraoptic nucleus (SON) rat, a unique astrocyte type is found with an ability to undergo striking morphological plasticity in response wide range physiological stimulations such as chronic hypernatraemia. This includes thinning VGL, which contains somata and proximal processes these astrocytes, well almost complete withdrawal their vertically-oriented distal processes. Currently, there little information available on types astrocytes that reside...
Magnocellular neurosecretory cells (MNCs) in the rat supraoptic nucleus display clustered firing during hyperosmolality or dehydration. This response is beneficial because this type of activity potentiates vasopressin secretion from axon terminals neurohypophysis and thus promotes homoeostatic water reabsorption kidney. However, mechanisms which lead to generation clustering MNCs remain unknown. Previous work has shown that can be induced these neurons through pharmacological activation NMDA...
Vasopressin (VP), an antidiuretic hormone, is also a potent vasoconstrictor and has been found at high levels in salt‐sensitive hypertensives. Hypertension normally reduces VP secretion by MNCs the SON, GABA‐dependent synaptic inhibition of their firing activities. However, rats under chronic hypernatremia, GABAA receptor‐mediated abolished SON neurons due to depolarization chloride reversal potential (ECl), suggesting that continued despite BP elevations may underlie development...