A5062056502- Renin-Angiotensin System Studies
- Nanoparticles: synthesis and applications
- Hormonal Regulation and Hypertension
- Algal biology and biofuel production
- Metal complexes synthesis and properties
- Seaweed-derived Bioactive Compounds
- Chemotherapy-induced cardiotoxicity and mitigation
- Synthesis and Characterization of Heterocyclic Compounds
- Electron Spin Resonance Studies
- Enzyme Structure and Function
- S100 Proteins and Annexins
- Cardiomyopathy and Myosin Studies
- Phytochemical and Pharmacological Studies
- Synthesis and biological activity
- Cardiovascular Function and Risk Factors
- Circadian rhythm and melatonin
- Ubiquitin and proteasome pathways
- Sodium Intake and Health
- Electrochemical sensors and biosensors
- Advanced Nanomaterials in Catalysis
- Protein Interaction Studies and Fluorescence Analysis
- Ovarian function and disorders
- Analytical Chemistry and Sensors
- Graphene and Nanomaterials Applications
- Eicosanoids and Hypertension Pharmacology
Louisiana State University Health Sciences Center New Orleans
2024
Southeast Louisiana Veterans Health Care System
2024
Cardiovascular Research Center
2024
Kalasalingam Academy of Research and Education
2019-2023
Targeted drug delivery systems are a promising field of research. Nano-engineered material-mediated possesses remarkable potential for the treatment various malignancies. Here, folic acid (FA)-conjugated bovine serum albumin (BSA) nanoparticles (NPs) were used to encapsulate myricetin (Myr). Subsequently, Myr via naturally overexpressed folate receptor (FR) FR-positive breast cancer cells was studied. Myr-loaded BSA NPs assembled by modified desolvation cross-linking technique. An...
BACKGROUND: Ang-II (angiotensin II) impairs the function of antihypertensive enzyme ACE2 (angiotensin-converting 2) by promoting its internalization, ubiquitination, and degradation, thus contributing to hypertension. However, few ubiquitination partners have been identified, their role in hypertension remains unknown. METHODS: Proteomics bioinformatic analyses were used identify brain, heart, kidney hypertensive C57BL6/J mice both sexes. The interaction between UBR1 (ubiquitin protein...
Coumarin derivatives are broadly used as anti-inflammatory, antioxidants, anticancer, and antiviral drugs in recent years. In particular, hydroxy coumarins have great importance because of their various biological pharmacological purposes. The quantum chemical studies 4,7-dihydroxycoumarin (DHC) been performed using the cc-pVTZ level basis set. DHC molecular structure has optimized computed frequency assignments correlated well with experimental results. [Formula: see text]C NMR shifts...
Abstract Developing a robust material holding antimicrobial assets has been an efficient strategy for reducing the risk of infections related to healthcare, significantly with medical devices and touch surfaces. Molybdenum-based compounds have drawn momentous attraction because their unique characteristics. A series undoped 5 % rare earth (Ce & La) doped metal (Ni, Co Bi) molybdate nanocomposites prepared by facile microwave combustion method characterized. The present study investigates...
Adriamycin is an effective anti-neoplastic drug against a variety of cancer types. However, the causes adverse side effects in number organ systems. Cardiomyopathy one life-threatening Adriamycin. In current work, we have derived hypothesis with possible involvement PPAR family members development Adriamycin-induced cardiomyopathy. Dysregulation by impairment transport and β-oxidation fatty acids, key substrate for ATP synthesis heart. Evidences suggest that dysregulation alters recruitment...
Cardiovascular diseases are the leading cause of disease burden globally. Sleep and cardiovascular connection represent a two-way lane. Recently, many reports have suggested that meditation practices beneficial effect on diseases. But exact mechanism was not known. Several suggest induces secretion melatonin. The rhythm melatonin follows sleep pattern. Thus, present hypothesis correlates plausible mechanisms involved in with enhancing cardiac health through synthesis. An altered modern...
Abstract Background Angiotensin (Ang)-II impairs the function of antihypertensive enzyme ACE2 by promoting its internalization, ubiquitination and degradation thus contributing to hypertension. However, few partners have been identified their role in hypertension remains unknown. Methods Proteomics bioinformatic analysis were used identify brain, heart, kidney from Ang-II-infused C57BL6/J mice both sexes validated interaction between UBR1 cells. Central peripheral knockdown was then...
Microglia, the resident immune cell in brain, contributes to neuroinflammation and neurogenic hypertension by secreting various cytokines chemokines. ADAM17 shedding of these signaling molecules) microglia modulates synaptic function but consequences this process have not been studied hypertension. Accordingly, we hypothesize that deletion opposes activation cytokine secretion thus preventing development salt-sensitive To test our hypothesis, a new mouse model (ADAM17::CX3CR1-CreERT2;...
Previous work from our group identified ADAM17-mediated shedding as a major mechanism responsible for ACE2 shedding, thus impairing compensatory activity and contributing to the development of salt sensitive hypertension. While microglia have been shown contribute hypertension, mechanisms are unknown. Accordingly, we hypothesize that ADAM17 promotes priming, sympatho-excitation neuro-inflammation in targeting or its maturation, via iRhom2, provides multi-pronged strategy normalize BP. Here,...
Doxorubicin is a well-known anthracycline antibiotic that frequently used to treat variety of malignancies. However, its clinical use limited due adverse consequences, most notably cardiomyopathy. In the present work, we evaluated molecular mechanisms behind impairment cardiac energetics in doxorubicin-induced According docking, interaction doxorubicin with phosphofructokinase (PKF) and α-enolase likely negatively affect glycolysis. The between HMOX1 results accumulation free iron. iron...
Doxorubicin (DOX) is an anthracycline antitumor drug, and though it a widely used chemotherapeutic agent to treat various types of cancers, induces irreversible dilated cardiomyopathy. In the face many attempts, molecular mechanism doxorubicin-induced cardiotoxicity has not been entirely determined. On this note, we hypothesize that doxorubicin might dysregulate calcium homeostasis through electron transport chain (ETC). Therefore, analyzed interaction with proteins involved in by docking....