A5057582014- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Acute Kidney Injury Research
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Sepsis Diagnosis and Treatment
Helsinki University Hospital
2020-2025
University of Helsinki
2020-2022
Abstract Background Acute kidney injury (AKI) is a frequent form of organ in cardiogenic shock. However, data on AKI markers such as plasma proenkephalin (P-PENK) and neutrophil gelatinase-associated lipocalin (P-NGAL) shock populations are lacking. The objective this study was to assess the ability P-PENK P-NGAL predict acute mortality Results were measured at different time points between baseline 48 h 154 patients from prospective CardShock study. outcomes assessed defined by an increase...
Cardiogenic shock (CS) is the deadliest manifestation of acute heart failure, with persistently high mortality rates and a lack recent therapeutic breakthroughs. Accurate risk prediction crucial in clinical decision-making design future trials. We aimed to validate CLIP score, biomarker-based score comprising cystatin C, lactate, interleukin-6 NT-proBNP, for predicting coronary syndrome (ACS) related CS, compare its predictive value previously published CardShock score. The study post hoc...
This study aimed to assess the utility of contemporary clinical risk scores and explore ability two biomarkers [growth differentiation factor-15 (GDF-15) soluble ST2 (sST2)] improve prediction in elderly patients with cardiogenic shock. Patients (n = 219) from multicentre CardShock were grouped according age (elderly ≥75 years younger). Characteristics, management, outcome between groups compared. The score IABP-SHOCK II predict in-hospital mortality additional value GDF-15 sST2 was...
Abstract Aims Soluble urokinase–type plasminogen activator receptor (suPAR) is a biomarker reflecting the level of immune activation. It has been shown to have prognostic value in acute coronary syndrome and heart failure as well critical illness. Considering complex pathophysiology cardiogenic shock (CS), we hypothesized suPAR might properties CS well. The aim this study was assess kinetics utility CS. Methods results SuPAR levels were determined serial plasma samples (0–96 h) from 161...
Abstract Aims Urgent revascularization is the mainstay of treatment in acute coronary syndrome (ACS) related cardiogenic shock (CS). The aim was to investigate association angiographic results with 90‐day mortality. Procedural complications percutaneous intervention (PCI) were also examined. Methods and This CardShock (NCT01374867) substudy included 158 patients ACS aetiology data on angiography during PCI procedure. Survival analysis conducted Kaplan–Meier curves Cox regression analysis....