A5067218534- High Altitude and Hypoxia
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Immunodeficiency and Autoimmune Disorders
- Alkaline Phosphatase Research Studies
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Neuroscience of respiration and sleep
- Medical research and treatments
- Public Health and Environmental Issues
- RNA Research and Splicing
- Neutropenia and Cancer Infections
- interferon and immune responses
Higher University of San Andrés
2016-2025
Instituto Boliviano de Ciencia y Tecnología Nuclear
2021-2025
Universidad Mesoamericana
2007
Azienda Ospedaliero Universitaria Ospedali Riuniti
1998-2002
University of Bergamo
1996-1998
Azienda Ospedaliera San Gerardo
1997
Ospedali Riuniti di Foggia
1996
Istituto di Ematologia di Bologna
1994
Background: Bolivian Andean Aymara highlanders, living at 4,000 m for 14,000 years, have evolved genetic adaptations to hypoxia. These include EGLN1 encoding prolyl hydroxylase 2 (PHD2), a regulator of transferrin transcription. Transferrin level increases in hypoxia and iron deficiency. Contrasting reports indicate that elevated is associated with experimentally induced thrombosis mice undergoing short-stay high altitude, but decreased congenital disorder hypoxia-sensing. Methods: A...
AbstractOver a time period of five years leukemic blast samples from 141 consecutive patients with adult ALL were referred to our laboratory, for molecular evaluation chromosome abnormalities. The t(9;22), t(4;11) and t(1;19) which are most commonly found in B-precursor phenotype molecularly analyzed by similar RT-PCR based protocols. BCR-ABL transcripts generated the t(9;22) translocation demonstrated 36 (25%) restricted 109 B precursor (33% this group). Of 83 showing common (CD10+), 34...
Three well-studied populations living at high altitudes are Tibetans, Andeans (Aymaras and Quechuas), Ethiopians. Unlike Tibetans Ethiopians who have similar hemoglobin (Hb) levels as individuals sea level, Aymara Hb increase when higher altitudes. Our previous whole genome study of people revealed several selected genes that involved in cardiovascular functions, but their relationship with was not elucidated. Here, we studied the frequencies known evolutionary-selected variants Tibetan...
Summary. Deletions involving the SIL‐TAL‐1 locus are seen in 15% of T‐acute lymphoblastic leukaemias (T‐ALL). To date, seven deletions have been described, spreading over 90 kb chromosome 1, fusing SIL to TAL‐1 gene and resulting expression TAL‐1. During diagnostic screening deletion 176 T‐ALL patients, we identified one case showing a new rearrangement. A novel fusion transcript was between exon 1a an unknown sequence (633‐cDNA). Polymerase chain reaction (PCR) human cDNA library confirmed...
Leucocyte alkaline phosphatase (LAP) is an enzyme expressed on the external aspect of neutrophilic granulocyte plasma membrane, and represents a specific marker for fully differentiated granulocyte. In this report we characterize 1B12.1, monoclonal antibody raised against human bone phosphatase, by its ability to recognize LAP protein. As assessed Western blot analysis, following electrophoresis under non-reducing conditions, specifically reacts with upon forced expression protein in simian...
Summary. The administration of granulocyte‐monocyte colony‐stimulating factor (GM‐CSF) was associated with complete clinical and haematological response in an adult patient minimally differentiated acute myeloid leukaemia who presented pneumonia moderate neutropenia, but no blast cells the peripheral blood. lasted 9 months. At relapse, a second GM‐CSF course resulted very good partial remission lasting 5 months, although differences kinetics haemoglobin, neutrophil platelet recovery were...