A5062752397- Carbohydrate Chemistry and Synthesis
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Glycosylation and Glycoproteins Research
- Genomics and Phylogenetic Studies
- Antifungal resistance and susceptibility
- Biochemical and Structural Characterization
- Monoclonal and Polyclonal Antibodies Research
- Bacterial Genetics and Biotechnology
- Bacterial Infections and Vaccines
Medizinische Hochschule Hannover
2022-2024
Bacterial capsules have critical roles in host-pathogen interactions. They provide a protective envelope against host recognition, leading to immune evasion and bacterial survival. Here we define the capsule biosynthesis pathway of Haemophilus influenzae serotype b (Hib), Gram-negative bacterium that causes severe infections infants children. Reconstitution this enabled fermentation-free production Hib vaccine antigens starting from widely available precursors detailed characterization...
Multidrug-resistant bacteria such as the opportunistic pathogen Pseudomonas aeruginosa, which causes life-threatening infections especially in immunocompromised individuals and cystic fibrosis patients, pose an increasing threat to public health. In search for new treatment options, P. aeruginosa uridine diphosphate-glucose pyrophosphorylase (PaUGP) has been proposed a novel drug target because it is required biosynthesis of important virulence factors linked pathogenicity animal models....
Abstract The human pathogenic fungus Aspergillus fumigatus synthesizes the zwitterionic glycolipid Manα1,3Manα1,6GlcNα1,2IPC, named Af3c. Similar glycosphingolipids having a glucosamine (GlcN) linked in α1,2 to inositolphosphoceramide (IPC) as core structure have only been described few fungi. Here, we describe an A. cluster of 5 genes (AFUA_8G02040 AFUA_8G02090) encoding proteins required for glycan part glycosphingolipid Besides already characterized UDP-GlcNAc:IPC...
In all kingdoms of life, the enzyme uridine diphosphate-glucose pyrophosphorylase (UGP) occupies a central role in metabolism, as its reaction product (UDP-Glc) is involved various crucial cellular processes. Pathogens, including fungi, parasites, and bacteria, depend on UGP for synthesis virulence factors; particular, bacterial species utilize UDP-Glc derivatives lipopolysaccharides, capsular polysaccharides, biofilm exopolysaccharides. UGPs have, therefore, gained attention anti-bacterial...